Thyroid Hormone Signaling and Cone Photoreceptor Viability.
Oklahoma City, United States. In Adv Exp Med Biol, Dec 2015
Treatment with thyroid hormone triiodothyronine (T3) or induction of high T3 by deleting the hormone-inactivating enzyme type 3 iodothyronine deiodinase (DIO3) causes cone death in mice.
Genetic abnormalities in thyroid hormone deiodinases.
Rotterdam, Netherlands. In Curr Opin Endocrinol Diabetes Obes, Oct 2015
RECENT FINDINGS: Common variation in DIO1 but not DIO2 or DIO3 is robustly associated with thyroid hormone levels at genome-wide levels of significance although the effect is modest.