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Deiodinase, iodothyronine, type III

Dio3, d-3, type 3 iodothyronine deiodinase, type III iodothyronine deiodinase
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, miR, ACID, type I 5'-deiodinase
Papers on Dio3
Neural and neuroendocrine processing of a non-photic cue in an opportunistically-breeding songbird.
Bentley et al., Berkeley, United States. In J Exp Biol, Feb 2016
UNASSIGNED: Recent studies of the onset of breeding in long-day photoperiodic breeders have focused on the roles of type 2 and 3 iodothyronine deiodinases (DIO2 and DIO3) in the conversion of thyroxine (T4) to triiodothyronine (T3) and subsequent activation of the reproductive axis.
Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour.
Cavaillé et al., Toulouse, France. In Hum Mol Genet, Feb 2016
UNASSIGNED: The brain-specific miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 domain is implicated in several aspects of brain development and function, particularly in fine-tuning the dendritic outgrowth and spine remodelling of hippocampal neurons.
Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity.
Shilatifard et al., Chicago, United States. In Genes Dev, Feb 2016
We identify the molecular regulators involved in the recruitment of AFF3 to gDMRs and provide mechanistic insight into the requirement of AFF3 at an enhancer for the expression of an ∼200-kb polycistronic transcript within the imprinted Dlk1-Dio3 locus.
Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions.
Segner et al., Bern, Switzerland. In Aquat Toxicol, Jan 2016
Both chemicals significantly altered transcript levels of thyroid system-related genes (TRα, TRβ, TPO, TSH, DIO1, DIO2 and DIO3) in a compound-specific way.
Thyroid Hormone Signaling and Cone Photoreceptor Viability.
Ding et al., Oklahoma City, United States. In Adv Exp Med Biol, Dec 2015
Treatment with thyroid hormone triiodothyronine (T3) or induction of high T3 by deleting the hormone-inactivating enzyme type 3 iodothyronine deiodinase (DIO3) causes cone death in mice.
Genetic abnormalities in thyroid hormone deiodinases.
Dayan et al., Rotterdam, Netherlands. In Curr Opin Endocrinol Diabetes Obes, Oct 2015
RECENT FINDINGS: Common variation in DIO1 but not DIO2 or DIO3 is robustly associated with thyroid hormone levels at genome-wide levels of significance although the effect is modest.
Thyroid Hormones in Brain Development and Function
Bernal, Madagascar. In Unknown Journal, Oct 2015
T4 and T3 are degraded by Dio3 present in neurons.
Molecular basis of imprinting disorders affecting chromosome 14: lessons from murine models.
Charalambous et al., London, United Kingdom. In Reproduction, May 2015
Mouse chromosome 12qF1 contains an imprinted region syntenic to human chromosome 14q32, collectively referred to as the Dlk1-Dio3 cluster.
Consumptive hypothyroidism due to a gastrointestinal stromal tumor expressing type 3 iodothyronine deiodinase.
Chen et al., Nanning, China. In Int J Clin Exp Med, 2014
On the other hand, it may lead to consumptive hypothyroidism, a rare syndrome caused by increased catabolism of T4 and T3 by increased type 3 iodothyronine deiodinase (D3) activity.
The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome.
Benvenisty et al., Jerusalem, Israel. In Nat Genet, 2014
In studying PWS-iPSCs and human parthenogenetic iPSCs, we unexpectedly found substantial upregulation of virtually all maternally expressed genes (MEGs) in the imprinted DLK1-DIO3 locus on chromosome 14.
Thyroid hormone inactivation in gastrointestinal stromal tumors.
Huang et al., Kōchi, Japan. In N Engl J Med, 2014
Here we report the finding of consumptive hypothyroidism caused by marked overexpression of the thyroid hormone-inactivating enzyme type 3 iodothyronine deiodinase (D3) within the tumor.
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.
Bray et al., Philadelphia, United States. In Nat Med, 2013
A disproportionately high number of microRNAs that were differentially expressed by race and PAR4 reactivity, including miR-376c, are encoded in the DLK1-DIO3 locus and were expressed at lower levels in platelets from black subjects.
Fine-tuning notes in the behavioral symphony: parent-of-origin allelic gene expression in the brain.
Redei et al., Chicago, United States. In Adv Genet, 2013
The gene encoding the thyroid hormone (TH)-metabolizing enzyme, deiodinase type III (Dio3), exhibits a preferential paternal expression in most tissues.
Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T₃in the mouse cerebral cortex.
Bernal et al., United States. In Endocrinology, 2012
Data indicate that, in normal physiological conditions, types 2 and 3 deiodinases (D2 and D3) play critical roles in maintaining local T(3) concentrations within a very narrow range.
Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice.
Bianco et al., Miami, United States. In Mol Endocrinol, 2012
Several lines of evidence including Dio3 knockout mice suggest that Dio3 plays crucial roles in heart function/dysfunction, ventricular remodeling, and pathogenesis of restrictive cardiomyopathy.
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.
Hochedlinger et al., Boston, United States. In Nat Genet, 2012
The generation of induced pluripotent stem cells (iPSCs) often results in aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster, compromising the ability to generate entirely iPSC-derived adult mice ('all-iPSC mice').
Imprinted gene dosage is critical for the transition to independent life.
Ferguson-Smith et al., Cambridge, United Kingdom. In Cell Metab, 2012
the imprinted delta-like homolog 1/preadipocyte factor (Dlk1/Pref1) and iodothyronine deiodinase type 3 (Dio3) functions converge on the development of brown fat at the transition to independent life.
The thyroid hormone degrading type 3 deiodinase is the primary deiodinase active in murine epidermis.
Safer et al., Boston, United States. In Thyroid, 2011
these data support the developing recognition that the primary role of thyroid hormone deiodinases in some tissues may be the degradation of thyroid hormone to protect the tissue against thyrotoxicosis.
The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion.
Bianco et al., Miami, United States. In Endocrinology, 2011
D3 expression in perinatal pancreatic beta-cells prevents untimely exposure to thyroid hormone, the absence of which leads to impaired beta-cell function and subsequently insulin secretion and glucose homeostasis
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