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Dimethylarginine dimethylaminohydrolase 1

dimethylarginine dimethylaminohydrolase, DDAH, G-6A, DDAH2
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: iNOS, CAN, V1a, HAD, Nitric Oxide Synthase
Papers on dimethylarginine dimethylaminohydrolase
Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China.
Qin et al., Shihezi, China. In Sao Paulo Med J, Feb 2016
CONTEXT AND OBJECTIVE: Dimethylarginine dimethylaminohydrolase enzymes (DDAH), which are encoded by the genes DDAH1 and DDAH2, play a fundamental role in maintaining endothelial function.
Placental NRP1 and VEGF expression in pre-eclamptic women and in a homocysteine-treated mouse model of pre-eclampsia.
Cheng et al., Shanghai, China. In Eur J Obstet Gynecol Reprod Biol, Jan 2016
The expression levels of Ddah1, Ddah2, eNos, Cbs and Cse were determined by quantitative RT-PCR to study the possible mechanism of hyperhomocysteinemia (HHcy).
A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia.
Nelin et al., Columbus, United States. In Acta Paediatr, Jan 2016
ADMA is metabolized by Nᴳ,Nᴳ- dimethylarginine dimethylaminohydrolase (DDAH).
Genotype polymorphisms of genes regulating nitric oxide synthesis determine long-term arteriovenous fistula patency in male hemodialysis patients.
Lin et al., Taipei, Taiwan. In Ren Fail, Jan 2016
Genotype polymorphisms of NO-biosynthesis regulating enzymes (DDAH-1, DDAH-2, eNOS and PRMT1) were compared between HD patients with (n = 161) and without (n = 419) history of AVF malfunction.
Icariin regulates PRMT/ADMA/DDAH pathway to improve endothelial function.
Luo et al., Changsha, China. In Pharmacol Rep, Dec 2015
BACKGROUND: Oxidative stress may affect PRMT/ADMA/DDAH (protein arginine methyltransferases/asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase) pathway to impair endothelial dysfunction.
Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers.
Ghebremariam et al., Houston, United States. In J Diabetes Res, Dec 2015
The concentration of ADMA in plasma and tissue is enzymatically regulated by dimethylarginine dimethylaminohydrolase (DDAH), a widely expressed enzyme in the cardiovascular system.
Demethylation treatment restores erectile function in a rat model of hyperhomocysteinemia.
Dai et al., Nanjing, China. In Asian J Androl, Dec 2015
Dimethylarginine dimethylaminohydrolase-2 (DDAH-2) protein is a pivotal molecular for endothelium function.
Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma.
Noguchi et al., Tsukuba, Japan. In Virchows Arch, Nov 2015
LC-MS/MS identified the protein recognized by this clone as dimethylarginine dimethylaminohydrolase 2 (DDAH2), an enzyme known for antiatherosclerotic activity.
The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
Itoh et al., Tokyo, Japan. In Nephrol Dial Transplant, Nov 2015
Transgenic (Tg) mice overexpressing each isoform of ADMA degrading enzyme, dimethylarginine dimethylaminohydrolase 1 (DDAH1) and DDAH2 were subject to Nx and their phenotypes were investigated.
Liver plays a central role in asymmetric dimethylarginine-mediated organ injury.
Vairetti et al., Pavia, Italy. In World J Gastroenterol, Jun 2015
ADMA is metabolized to citrulline and dimethylamine, by dimethylarginine dimethylaminohydrolase (DDAH) and enters cells through cationic amino-acid transporters extensively expressed in the liver.
The endothelial ADMA/NO pathway in hypoxia-related chronic respiratory diseases.
Hennigs et al., Hamburg, Germany. In Biomed Res Int, 2013
In particular, the regulation of ADMA by its degrading enzyme dimethylarginine dimethylaminohydrolase (DDAH) is the object of many studies.
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model.
Huang et al., Kao-hsiung, Taiwan. In Int J Mol Sci, 2013
BDL rats have higher plasma and hepatic ADMA levels, which may be due to increased hepatic protein arginine methyltransferase-1 and decreased dimethylarginine dimethylaminohydrolase expression.
Pharmacology and clinical pharmacology of methylarginines used as inhibitors of nitric oxide synthases.
Maas et al., Erlangen, Germany. In Curr Pharm Des, 2013
Key pharmacodynamic and pharmacokinetic data including IC50 values of ADMA and L-NMMA for NOS isoforms and transport proteins, as well as metabolism by dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) and alanine-glyoxylate aminotransferase 2 (AGXT2) are discussed.
Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid.
Nazarian et al., Washington, D.C., United States. In Neuro Oncol, 2012
High DDAH1 is associated with pediatric diffuse intrinsic pontine glioma.
Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes.
Burdon et al., Australia. In J Diabetes Complications, 2012
Genetic polymorphisms in DDAH genes influence serum ADMA levels in individuals with T1 diabetes mellitus.
Pilot study of the association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis.
Wainwright et al., Chicago, United States. In Plos One, 2011
The -449G single nucleotide polymorphism within the DDAH2 gene was associated with both decreased plasma asymmetric dimethylarginine and an increased likelihood of presenting with "cold" shock in pediatric sepsis.
A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity.
Sesti et al., Catanzaro, Italy. In Plos One, 2011
A functional polymorphism of the DDAH2 gene may confer increased risk for type 2 diabetes by affecting insulin sensitivity
Exercise blood pressure response is related to asymmetric dimethylarginine and osteoprotegerin in hypertension.
Stefanadis et al., In Int J Cardiol, 2011
Non-diabetic hypertensive subjects with a hypertensive response to exercise compared to those with normal response were characterized by augmented asymmetric dimethylarginine and osteoprotegerin levels.
The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis.
Nandi et al., London, United Kingdom. In Nat Rev Drug Discov, 2011
In addition to its renal clearance, endogenously produced ADMA is metabolized to L-citrulline and dimethylamine by the dimethylarginine dimethylaminohydrolase (DDAH) enzymes.
Disruption of methylarginine metabolism impairs vascular homeostasis.
Vallance et al., London, United Kingdom. In Nat Med, 2007
DDAH-1 activity leads to accumulation of asymmetric dimethylarginine and reduction in nitric oxide signaling.
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