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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inhibitor of apoptosis 2

DIAP2, mDia3
Top mentioned proteins: cytochrome b5 reductase, Actin, PrP, Rhodopsin, Cx26
Papers on DIAP2
Distinct actin oligomers modulate differently the activity of actin nucleators.
New
Mannherz et al., Bochum, Germany. In Febs J, Oct 2015
Native gel electrophoresis demonstrated binding of LD, UD and trimer to gelsolin and its fragment G1-3, to the FH2 domains of the formins mDia1 and mDia3, and to Arp2/3 complex.
Suppression of induced but not developmental apoptosis in Drosophila by Ayurvedic Amalaki Rasayana and Rasa-Sindoor.
New
Lakhotia et al., Benares, India. In J Biosci, Jun 2015
AR or RS supplement enhanced levels of inhibitor of apoptosis proteins, DIAP1 and DIAP2, and of Bancal/Hrb57A, while the levels of RHG proteins and of initiator Dronc and effecter Drice caspases were reduced in non-apoptotic wild type as well as in RHG over-expressing tissues.
The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes.
New
Brumell et al., Ottawa, Canada. In J Infect Dis, May 2015
In addition, the Diaphanous-related formins 1-3 (mDia1-3) localized to protrusions, and knockdown of mDia1, mDia2, and mDia3 substantially decreased cell-to-cell spread of L. monocytogenes.
Platelet Rho GTPases-a focus on novel players, roles and relationships.
Review
New
Poole et al., Bristol, United Kingdom. In Biochem J, Apr 2015
In human platelets, Rif interacts with cytoskeleton regulators including formins mDia1 and mDia3, whereas RhoG binds SNARE-complex proteins and cytoskeletal regulators ELMO and DOCK1.
Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres.
New
Mannherz et al., Bochum, Germany. In Eur J Cell Biol, Feb 2015
Immunostaining of cardiac muscle sections or ARCs with antibodies against mDia3-FH2-domain showed colocalisation with cadherin along the lateral border of cardiomyocytes suggesting also its presence in costameres.
Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration.
Badache et al., Marseille, France. In Mol Biol Cell, 2014
Here we further study the contributions of mDia1 and its two most closely related formins, mDia2 and mDia3, to cortical microtubule capture and ErbB2-dependent breast carcinoma cell migration.
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.
Matter et al., Porto, Portugal. In Nat Commun, 2013
Loss of DLC2 induces the mislocalization of Kif1B, increased Cdc42 activity and cortical recruitment of the Cdc42 effector mDia3, a microtubule stabilizer and promoter of actin dynamics.
EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.
Narumiya et al., Kyoto, Japan. In Genes Cells, 2013
Here, we found that mice lacking mDia1 and mDia3, two isoforms expressed in the brain, in combination (mDia-DKO mice) show impaired left-right limb coordination during locomotion and aberrant midline crossing of axons of corticospinal neurons and spinal cord interneurons.
RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.
Endo et al., Chiba, Japan. In Mol Biol Cell, 2012
Knockdown of mDia3 obstructed RhoD-induced protrusion formation.
mDia1-3 in mammalian filopodia.
Ahmed et al., Singapore, Singapore. In Commun Integr Biol, 2012
RhoGTPases bind to and control the activity of mDia proteins, and several other binding partners of the three mDia1 isoforms-mDia1, mDia2 and mDia3-have been documented.
Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.
GeneRIF
Meier et al., London, United Kingdom. In Embo J, 2012
The authors show that stimulation of the Drosophila pattern recognition protein PGRP-LCx induces DIAP2-dependent polyubiquitylation of the initiator caspase DREDD.
Innate immunity: regulation of caspases by IAP-dependent ubiquitylation.
Boutros et al., Mannheim, Germany. In Embo J, 2012
The authors show that infection with gram-negative bacteria leads to DIAP2-dependent ubiquitylation of Dredd which in turn is required for processing of Relish (Rel) and expression of antimicrobial peptide (AMP) genes that are indispensable for fighting the infection.
FORMIN a link between kinetochores and microtubule ends.
Review
Mao, New York City, United States. In Trends Cell Biol, 2011
Recently, the formin mDia3 was shown to associate with the kinetochore and to contribute to metaphase chromosome alignment, a process in which kinetochores form stable attachments with growing and shrinking microtubules.
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
GeneRIF
Narumiya et al., Kyoto, Japan. In Plos One, 2010
actin cytoskeleton regulated by Rho-mDia pathway is critical for the integrity of the adherens junctions and the polarity of neuroepithelial cells
Specificity of interactions between mDia isoforms and Rho proteins.
GeneRIF
Wittinghofer et al., Dortmund, Germany. In J Biol Chem, 2009
analysis of interactions between mDia isoforms 1, 2, and 3 and RhoA, Rac1, and Cdc42
Expression of the diaphanous-related formin proteins mDia1 and mDia2 in the rat testis.
GeneRIF
Millette et al., Columbia, United States. In Dev Dyn, 2008
mDia1 and mDia2 are indeed involved in the regulation of Sertoli cell and germ structure during mammalian spermatogenesis
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
GeneRIF
Meier et al., London, United Kingdom. In J Cell Biol, 2008
Because DIAP2 efficiently interacts with drICE, our data suggest that DIAP2 controls drICE in its apoptotic and nonapoptotic roles.
A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment.
Review
Yasuda et al., Kyoto, Japan. In Cell Cycle, 2004
We have recently found that Cdc42 and its downstream effector mDia3 are involved in bi-orientation and stabilization of spindle microtubules attachment to kinetochores and regulate chromosome alignment and segregation.
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Impact
GeneRIF
Narumiya et al., Kyoto, Japan. In Nature, 2004
Cdc42, and its effector, mDia3, regulate microtubule attachment to kinetochores
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death.
Impact
Rubin et al., Berkeley, United States. In Cell, 1996
Overexpression of DIAP1 or a related protein, DIAP2, in the eye suppresses normally occurring cell death as well as death due to overexpression of rpr or head involution defective.
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