mDia1-3 in mammalian filopodia.
Singapore, Singapore. In Commun Integr Biol, 2012
RhoGTPases bind to and control the activity of mDia proteins, and several other binding partners of the three mDia1 isoforms-mDia1, mDia2 and mDia3-have been documented.
Innate immunity: regulation of caspases by IAP-dependent ubiquitylation.
Mannheim, Germany. In Embo J, 2012
The authors show that infection with gram-negative bacteria leads to DIAP2-dependent ubiquitylation of Dredd which in turn is required for processing of Relish (Rel) and expression of antimicrobial peptide (AMP) genes that are indispensable for fighting the infection.
FORMIN a link between kinetochores and microtubule ends.
New York City, United States. In Trends Cell Biol, 2011
Recently, the formin mDia3 was shown to associate with the kinetochore and to contribute to metaphase chromosome alignment, a process in which kinetochores form stable attachments with growing and shrinking microtubules.