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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Contactin 2

Diacylglycerol O-Acyltransferase, diacylglycerol acyltransferase, DGAT1, TAG-1, DGAT, Tax1
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, DGAT2, CAN, HAD, STEP
Papers on Diacylglycerol O-Acyltransferase
DGAT2 Mutation in a Family with Autosomal Dominant Early-Onset Axonal Charcot-Marie-Tooth Disease.
Chung et al., Seoul, South Korea. In Hum Mutat, Feb 2016
Pedigree analysis and exome sequencing identified a de novo missense mutation (p.Y223H) in the diacylglycerol O-acyltransferase 2 (DGAT2) gene.
Lipid metabolism and the risk factors of cardiovascular disease: implication of dietary omega-3 polyunsaturated fatty acids.
Balogun, St. John's, Canada. In Appl Physiol Nutr Metab, Feb 2016
High n-3 PUFA diet also led to the downregulation of the messenger RNA expression of acyl-CoA:diacylglycerol acyltransferase 2, fatty acid binding protein-4, peroxisome proliferator-activated receptor protein γ, and leptin in males, which are key proteins involved in adipocyte hypertrophy; however, no effect was observed in females.
Four new sesqui-lignans isolated from Acanthopanax senticosus and their diacylglycerol acyltransferase (DGAT) inhibitory activity.
Cui et al., Taiwan. In Fitoterapia, Feb 2016
All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2.
Novel therapeutics in hypertriglyceridemia.
Hegele et al., London, Canada. In Curr Opin Lipidol, Dec 2015
Other potential therapies include small molecule inhibitors of microsomal triglyceride transfer protein (lomitapide) and diacylglycerol acyltransferase-1 (pradigastat), and a monoclonal antibody against angiopoietin-like protein 3 (REGN1500).
Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse.
Gardner et al., San Francisco, United States. In J Steroid Biochem Mol Biol, Oct 2015
We, therefore, examined the effects of VDR deficiency (VDR(-/-) mouse) in a murine model of cardiac steatosis that expresses the terminal enzyme involved in triglyceride synthesis, diacylglycerol acyltransferase 1 (DGAT1), selectively in the cardiac myocyte.
Effect of short-chain fatty acids on triacylglycerol accumulation, lipid droplet formation and lipogenic gene expression in goat mammary epithelial cells.
Loor et al., China. In Anim Sci J, Sep 2015
The expression of FABP3, SCD1, PPARG, SREBP1, DGAT1, AGPAT6 and ADRP were upregulated by propionate and butyrate treatment.
[Effect of Jinlida on DGAT1 in Skeletal Muscle in Fat-Induced Insulin Resistance ApoE -/- Mice].
Cui et al., In Zhong Yao Cai, Jun 2015
The mRNA and protein expression of insulin receptor substrate (IRS-1) and diacylglycerol acyltransferase 1 (DGAT1) in skeletal muscle were measured by real-time quantitative reverse transcription PCR (RT-PCR)and Western blot.
Chylomicronaemia--current diagnosis and future therapies.
Hegele et al., London, Canada. In Nat Rev Endocrinol, Jun 2015
Emerging therapies that might prove more effective than existing agents include LPL gene therapy, inhibition of microsomal triglyceride transfer protein and diacylglycerol O-acyltransferase 1, and interference with the production and secretion of apoC-III and angiopoietin-like protein 3.
Go with the flow-biology and genetics of the lactation cycle.
Brockmann et al., Armidale, Australia. In Front Genet, 2014
The most prominent gene affecting milk yield and milk fat, DGAT1, exhibits its main effects after peak production, whilst the casein genes have larger effects in early lactation.
Inhibitors of Myocyte Triacylglyceride Accumulation
Kelly et al., Bethesda, United States. In Unknown Journal, 2014
Furthermore, the compounds tested negatively for DGAT inhibition and cytotoxicity.
Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells.
Zammit et al., Coventry, United Kingdom. In Febs J, 2012
describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1
TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex.
Furley et al., Sheffield, United Kingdom. In J Neurosci, 2012
These observations identify a novel role for TAG1 in modulating the intracellular sorting of signaling receptor complexes.
Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy.
Ho et al., Hong Kong, Hong Kong. In J Peripher Nerv Syst, 2012
The single-nucleotide polymorphism (SNP) rs2275697 in the TAG-) gene was not associated with treatment responsiveness, treatment dependence, disability, or mortality in chronic inflammatory demyelinating polyneuropathy
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
Farese et al., San Francisco, United States. In Aging (albany Ny), 2012
Deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.
Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2.
Taylor et al., Saskatoon, Canada. In Bmc Plant Biol, 2011
Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2.
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
Ott et al., San Francisco, United States. In Nat Med, 2010
The triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) is identified as a key host factor for hepatitis C virus infection.
A phenylalanine in DGAT is a key determinant of oil content and composition in maize.
Shen et al., United States. In Nat Genet, 2008
Here we show that a high-oil QTL (qHO6) affecting maize seed oil and oleic-acid contents encodes an acyl-CoA:diacylglycerol acyltransferase (DGAT1-2), which catalyzes the final step of oil synthesis.
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
Farese et al., San Francisco, United States. In Cell Metab, 2007
To test the causal relationship between hepatic steatosis and insulin resistance, we generated mice that overexpress acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2), which catalyzes the final step of triacylglycerol (TG) biosynthesis, in the liver (Liv-DGAT2 mice).
The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion.
Welte et al., Konstanz, Germany. In Cell, 2000
We have determined the crystal structure of the ligand binding fragment of the neural cell adhesion molecule axonin-1/TAG-1 comprising the first four immunoglobulin (Ig) domains.
The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity.
Jessell et al., New York City, United States. In Cell, 1990
One molecule suggested to play a role in axonal growth is TAG-1, a 135 kd glycoprotein expressed transiently on the surface of subsets of neurons in the developing mammalian nervous system.
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