Novel therapeutics in hypertriglyceridemia.
London, Canada. In Curr Opin Lipidol, Dec 2015
Other potential therapies include small molecule inhibitors of microsomal triglyceride transfer protein (lomitapide) and diacylglycerol acyltransferase-1 (pradigastat), and a monoclonal antibody against angiopoietin-like protein 3 (REGN1500).
Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse.
San Francisco, United States. In J Steroid Biochem Mol Biol, Oct 2015
We, therefore, examined the effects of VDR deficiency (VDR(-/-) mouse) in a murine model of cardiac steatosis that expresses the terminal enzyme involved in triglyceride synthesis, diacylglycerol acyltransferase 1 (DGAT1), selectively in the cardiac myocyte.