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Glyceronephosphate O-acyltransferase

This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: amylin, ACID, CAN, HAD, catalase
Papers on DHAP-AT
Deletion of liaR Reverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic Background.
Arias et al., Houston, United States. In Antimicrob Agents Chemother, Dec 2015
Moreover, DAP at concentrations of 13 μg/ml (achieved with human doses of 12 mg/kg body weight) retained bactericidal activity against the mutants.
Telavancin demonstrates activity against methicillin-resistant Staphylococcus aureus isolates with reduced susceptibility to vancomycin, daptomycin, and linezolid in broth microdilution MIC and one-compartment pharmacokinetic/pharmacodynamic models.
Rybak et al., Detroit, United States. In Antimicrob Agents Chemother, Sep 2015
Four isolates were randomly selected for 168-h in vitro models to evaluate treatment with TLV at 10 mg/kg of body weight/day, DAP at 10 mg/kg/day, VAN at 1 g every 12 h (q12h), and LZD at 600 mg q12h.
Evaluation of Residual Antibacterial Effect of Human Radicular Dentin Treated with Triple and Double Antibiotic Pastes.
Gregory et al., Amman, Jordan. In J Endod, Jul 2015
For treatment groups, specimens were treated with either TAP or DAP at various concentrations (1000, 1, or 0.5 mg/mL) for 2 weeks.
Kezhun et al., In Klin Med (mosk), 2014
The endothelin-1 level 10.51 pg/ml or higher measured with a sensitivity of 8% allows to predict, regardless of the 25(OH)D level, the superthreshold values of the following APM parameters: mean daily SAP/DAP during 24 hours, day- and night-time, SAP/DAP time index during 24 hours and daytime, enhanced SAP/DAP variability at night-time, DAP at daytime.
Preparation and bioactive properties of nanocrystalline hydroxyapatite thin films obtained by conversion of atomic layer deposited calcium carbonate.
Ritala et al., Helsinki, Finland. In Biointerphases, 2014
ToF-elastic recoil detection analysis studies revealed that the films are calcium deficient in relation to hydroxyapatite with a Ca/P ratio of 1.39 for films converted with 0.2 M DAP at 95 °C.
Effect of dentin conditioning with intracanal medicaments on survival of stem cells of apical papilla.
Diogenes et al., San Antonio, United States. In J Endod, 2014
RESULTS: Exposure of dentin to TAP or DAP at 1000 mg/mL resulted in no viable SCAP, whereas the use of these medicaments at 1 mg/mL had no adverse effect on cell viability.
Effectiveness of antibiotic medicaments against biofilm formation of Enterococcus faecalis and Porphyromonas gingivalis.
Gregory et al., Amman, Jordan. In J Endod, 2013
Biofilm formation of the 2 bacteria was significantly decreased with TAP and DAP at all tested dilutions (P < .0001)
Effects of combined oral contraceptives containing levonorgestrel or chlormadinone on the endothelium.
Ferriani et al., Ribeirão Preto, Brazil. In Contraception, 2013
RESULTS: Relative to baseline, EE/CMA users showed a significant reduction in mean DAP at 6 months (p=.02), and EE/LNG users showed a significant increase in mean IMT (p=.02) and a significant reduction in mean FMD (p=.01) at 6 months.
Inoculum effects of ceftobiprole, daptomycin, linezolid, and vancomycin with Staphylococcus aureus and Streptococcus pneumoniae at inocula of 10(5) and 10(7) CFU injected into opposite thighs of neutropenic mice.
Craig et al., Madison, United States. In Antimicrob Agents Chemother, 2013
CFU/thigh (low inoculum [LI]) in one thigh and 10(6.4) to 10(7.2) CFU/thigh (high inoculum [HI]) in the opposite thigh when treated for 24 h with subcutaneous (s.c.) doses every 12 h of DAP at 0.024 to 100 mg/kg of body weight and LZD at 0.313 to 320 mg/kg and s.c.
Identification and expression analysis of GPAT family genes during early development of Xenopus laevis.
McFarlane et al., Calgary, Canada. In Gene Expr Patterns, 2012
DHAPAT (EC2.3.1.42)
Impaired neurotransmission in ether lipid-deficient nerve terminals.
Just et al., Heidelberg, Germany. In Hum Mol Genet, 2012
Data show that EL deficiency (DHAPAT-null) caused the reduction in synaptic respiratory activity and consequently the decrease in the ATP/ADP ratio by >20%.
Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3.
Braverman et al., Montréal, Canada. In Hum Mutat, 2012
Novel mutations in GNPAT cause rhizomelic chondrodysplasia punctata (RCDP) type 2.
A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention.
Hwu et al., Taipei, Taiwan. In Biol Psychiatry, 2006
Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia.
Comparison of the effects of remifentanil andalfentanil on cardiovascular response to nasotracheal intubation: A prospective, randomized, double-blind study.
Menekse et al., Diyarbakır, Turkey. In Curr Ther Res Clin Exp, 2005
However, SAP, DAP, and HR remained significantly lower compared with baseline values throughout the study period in both groups (all, P < 0.05) except DAP at 1 minute after incubation in the alfentanil group.
Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids.
Zoeller et al., Boston, United States. In J Lipid Res, 2005
peroxisomal DHAPAT is essential for the biosynthesis of plasmalogens in animal cells
Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22:6n-3) biosynthesis.
Huszagh et al., Ithaca, United States. In Mol Genet Metab, 2001
These decreased brain 22:6n-3 concentrations appear to be secondary to impaired plasmalogen (sn-1-alkyl-, alkenyl-2-acyl glycerophospholipids) synthesis, probably at the level of the dihydroxyacetonephosphate acyltransferase (DHAP-AT), a peroxisomal enzyme catalyzing the first step in the synthesis of 22:6n-3-rich plasmalogens.
Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor.
Lazarow et al., New York City, United States. In Nat Genet, 1997
We show that expression of human PEX7 in RCDP cells rescues PTS2 targeting and restores some activity of dihydroxyacetone phosphate acyltransferase (DHAP-AT), a peroxisomal enzyme of plasmalogen biosynthesis, and we identify the mutations responsible for loss of function of PEX7 in a compound heterozygote RCDP patient.
Zellweger syndrome and associated phenotypes.
FitzPatrick, Edinburgh, United Kingdom. In J Med Genet, 1996
It is important that clinical geneticists are aware of these milder clinical variants as the availability of sensitive and specific biochemical assays of peroxisomal function (for example, serum VLCFA ratios, platelet DHAP-AT activity) makes their diagnosis relatively straightforward.
[Chondrodysplasia punctata (the Conradi-Hünermann syndrome). A clinical case report and review of the literature].
Goetsch et al., Bolzano - Bozen, Italy. In Minerva Pediatr, 1993
The rhizomelic form of CDP is considered a peroxisomal disorder, due to reduced activity of some enzymes: DHAP-AT, phytanic acid oxidase, alkil DHAP synthase.
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