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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Heart and neural crest derivatives expressed 2

DH and, HAND2
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TH2, HAD, CAN, ACID, AGE
Papers on DH and
Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group.
Review
New
ENDA/EAACI Drug Allergy Interest Group et al., Porto, Portugal. In Allergy, Feb 2016
Whereas this appears generally acceptable, some aspects of DH and management differ with age.
Chronic administration of resveratrol prevents morphological changes in prefrontal cortex and hippocampus of aged rats.
New
Flores et al., Mexico. In Synapse, Feb 2016
Interestingly, the enhancement in dendritic length was close to the soma in pyramidal neurons of the PFC, whereas in neurons of the DH and DG, the increase in dendritic length was further from the soma.
Pulmonary transcriptome analysis in the rabbit model of surgically-induced diaphragmatic hernia treated with fetal tracheal occlusion.
New
Deprest et al., Leuven, Belgium. In Dis Model Mech, Feb 2016
But DH+TO was associated with an up-regulation of 157 genes compared to DH and controls.
Major dorsoventral differences in the modulation of the local CA1 hippocampal network by NMDA, mGlu5, adenosine A2A and cannabinoid CB1 receptors.
New
Papatheodoropoulos et al., Pátrai, Greece. In Neuroscience, Feb 2016
These findings show that the NMDAR-dependent modulation of fundamental parameters of the local neuronal network, by mGluR, A2AR and CB1R, markedly differs between DH and VH.
Trend of Cadherin-11 expression and its impact on cartilage degradation in the temporomandibular joints of guinea pigs with spontaneous osteoarthritis.
New
Zhou et al., Hangzhou, China. In J Oral Pathol Med, Jan 2016
The bilateral TMJ condyles of DH and BS2 guinea pigs were harvested and fixed.
Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases.
New
Chahine et al., North Bay Shore, United States. In Arthritis Res Ther, Dec 2015
Comparison between subjects with DH and those with other diagnoses (Other Dx, grouped from SS and DDD) was performed to elaborate a pathological mechanism based on circulating cytokine levels.
Circuitry and plasticity of the dorsal horn--toward a better understanding of neuropathic pain.
Review
New
Bennett et al., Oxford, United Kingdom. In Neuroscience, Sep 2015
Advances in genetic engineering, tracing techniques and opto-genetics are leading to a much better understanding of the complex circuitry of the spinal DH and the radical changes evoked in such circuitry by nerve injury.
Engaging children and parents in service design and delivery.
Review
Kitt et al., Belfast, United Kingdom. In Arch Dis Child, 2014
User engagement and patient choice, is underpinned by the NHS outcomes framework, and a myriad of other DH and NHS England policies and practice frameworks.
Chromatin Interactions in the Control of Immunoglobulin Heavy Chain Gene Assembly.
Review
Sen et al., Baltimore, United States. In Adv Immunol, 2014
For this, the germline locus is divided into two parts: a 2.4Mb 5' part that contains all VH gene segments and a 300kb 3' domain that contains DH and JH gene segments, as well as exons that encode IgH isotypes.
Beyond the Intestinal Celiac Mucosa: Diagnostic Role of Anti-TG2 Deposits, a Systematic Review.
Review
Catassi et al., Ancona, Italy. In Front Med (lausanne), 2013
CONCLUSION: Transglutaminase 2 IgA deposits seem to be a constant feature in overt CD patients and are frequently detectable in other gluten-related conditions (DH and GA).
Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.
Impact
De Windt et al., Maastricht, Netherlands. In Nat Cell Biol, 2013
Here we report that increased calcineurin/Nfat signalling and decreased miR-25 expression integrate to re-express the basic helix-loop-helix (bHLH) transcription factor dHAND (also known as Hand2) in the diseased human and mouse myocardium.
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Review
Impact
Bassel-Duby et al., Dallas, United States. In Nat Rev Mol Cell Biol, 2013
Heart function has been restored in rodents by reprogramming non-myocytes into cardiomyocytes, by expressing transcription factors (GATA4, HAND2, myocyte-specific enhancer factor 2C (MEF2C) and T-box 5 (TBX5)) and microRNAs (miR-1, miR-133, miR-208 and miR-499) that control cardiomyocyte identity.
Identification and characterization of the zebrafish pharyngeal arch-specific enhancer for the basic helix-loop-helix transcription factor Hand2.
GeneRIF
Clouthier et al., Aurora, United States. In Dev Biol, 2012
Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Impact
Olson et al., Dallas, United States. In Nature, 2012
Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro.
No evidence of HAND2 involvement in nonsyndromic cleft lip with or without cleft palate.
GeneRIF
Scapoli et al., Bologna, Italy. In Clin Oral Investig, 2012
No evidence of linkage between HAND2 and CL/P was obtained. Levelss of exclusion were obtained with different inheritance models. results did not support HAND2 in CL/P
A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis.
GeneRIF
Firulli et al., Indianapolis, United States. In J Neurosci, 2012
Expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner during sympathetic neurogenesis.
Evidence for a conserved function of heart and neural crest derivatives expressed transcript 2 in mouse and human decidualization.
GeneRIF
Bany et al., Carbondale, United States. In Reproduction, 2011
Data suggest Hand2 plays an important role in decidualization; expression of Hand2 is significantly increased in response to prostaglandin E2.
Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development.
GeneRIF
Firulli et al., Indianapolis, United States. In Circ Res, 2011
Hand2 performs an essential role during transgenic epicardialization, directly impacting epicardial cell differentiation and formation of the coronary vasculature.
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Impact
Tesmer et al., Mannheim, Germany. In Science, 2008
We determined the crystal structure of the Galphaq-p63RhoGEF-RhoA complex, detailing the interactions of Galphaq with the Dbl and pleckstrin homology (DH and PH) domains of p63RhoGEF.
Fin development in a cartilaginous fish and the origin of vertebrate limbs.
Impact
Tickle et al., Dundee, United Kingdom. In Nature, 2002
In contrast, unlike higher vertebrates, we did not detect Shh transcripts in dogfish fin-buds, although dHand (a gene involved in establishing Shh) is expressed.
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