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proteins. Page last changed on 08 Dec 2016.
Diacylglycerol kinase, iota
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008] (from
Heilig et al., Huddinge, Sweden. In Mol Psychiatry, 2001
Diacylglycerol kinaseiota is exclusively found in the brain and is expressed in a distinct regional pattern. Differential expression of splice variants in the cortex of alcohol accepting (AA) and alcohol non-accepting (ANA) rat lines.