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Diacylglycerol kinase, iota

DGKiota, DGKI
This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DGKzeta, ACID, ADRP, DYX1C1, Robo1
Papers on DGKiota
A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance.
Zhao et al., Nashville, United States. In Mol Cancer Ther, 2014
Third, we identified 12 significantly mutated genes in "pan-negative" samples (ALK, STK31, DGKI, RAC1, EPHA4, ADAMTS18, EPHA7, ERBB4, TAF1L, NF1, SYK, and KDR), including five genes (RAC1, ADAMTS18, EPHA7, TAF1L, and NF1) with a recurrent mutation in at least two "pan-negative" tumor samples.
SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations.
GeneRIF
Peyrard-Janvid et al., Huddinge, Sweden. In Behav Genet, 2011
Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33.
DNA methylation in glioblastoma: impact on gene expression and clinical outcome.
Mosser et al., Rennes, France. In Bmc Genomics, 2009
The methylation status of the FNDC3B, TBX3, DGKI, and FSD1 promoters identified patients with MGMT-methylated tumors that did not respond to STUPP treatment (p-value < 1e-04).
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
O'Donovan et al., Cardiff, United Kingdom. In Mol Psychiatry, 2009
Among those genes surpassing thresholds highly enriched for true association, we observed evidence for association to genes reported in other GWAS data sets (CACNA1C) or to closely related family members of those genes including CSF2RB, CACNA1B and DGKI.
Nuclear diacylglycerol kinases: regulation and roles.
Review
Tu-Sekine et al., Baltimore, United States. In Front Biosci, 2007
In this review we focus primarily on the nuclear localization, modulation of intrinsic enzymatic activity, and the potential physiological roles of the six diacylglycerol kinases that have been found in the nucleus: DGK-alpha, DGK-gamma, DGK-delta, DGK-zeta, DGK-iota, and DGK-theta.
Gene expression and localization of diacylglycerol kinase isozymes in the rat spinal cord and dorsal root ganglia.
Goto et al., Yamagata, Japan. In Cell Tissue Res, 2006
Among the isozymes, most intense signals were found for DGKzeta and DGKiota in the DRG.
Diacylglycerol kinase zeta is involved in the process of cerebral infarction.
Goto et al., Yamagata, Japan. In Eur J Neurosci, 2006
In the early phase of 90 min of middle cerebral artery occlusion, DGKzeta-immunoreactivity is reduced rapidly in the nucleus of cortical neurons in the ischemic core, while DGKiota and other neuronal proteins such as MAP-2 and NeuN remain intact.
Gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta.
Goto et al., Yamagata, Japan. In Cell Tissue Res, 2005
At higher magnification, the signals for DGKalpha were mainly discerned in giant cytotrophoblasts, and those for DGKiota were found in small cytotrophoblasts of the junctional zone.
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.
Topham et al., Salt Lake City, United States. In Proc Natl Acad Sci U S A, 2005
To study the physiological function of diacylglycerol (DAG) kinase iota (DGKiota), which converts DAG to phosphatidic acid, we deleted this gene in mice.
Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain.
GeneRIF
Goto et al., Yamagata, Japan. In J Biol Chem, 2004
novel splice variants, which contain either insertion 1 (71 bp) or insertion 2 (19 bp) or both in the carboxyl-terminal portion
Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats.
GeneRIF
Heilig et al., Huddinge, Sweden. In Mol Psychiatry, 2001
Diacylglycerol kinase iota is exclusively found in the brain and is expressed in a distinct regional pattern. Differential expression of splice variants in the cortex of alcohol accepting (AA) and alcohol non-accepting (ANA) rat lines.
Evaluation of human diacylglycerol kinase(iota), DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q.
Daiger et al., Houston, United States. In Mol Vis, 2000
PURPOSE: To determine the genomic organization of diacylglycerol kinase(iota) and to test whether defects in this gene are present in individuals affected with autosomal dominant retinitis pigmentosa (adRP).
The cloning and characterization of a novel human diacylglycerol kinase, DGKiota.
Prescott et al., Salt Lake City, United States. In J Biol Chem, 1999
We isolated a novel DGK, which we designated DGKiota, from human retina and brain libraries.
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