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proteins. Page last changed on 19 Dec 2016.
Diacylglycerol kinase, eta
DGKH, DGKeta, DGK eta 2, DAG kinase eta, DGK eta 1
This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family of proteins, specifically the type II DGK subfamily. Members of this family are involved in regulating the intracellular concentrations of diacylglycerol and phosphatidic acid. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2011] (from
NCBI)
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Top mentioned proteins:
endothelin receptor, ankyrin-G, Cav1.2, ACID, OUT
Papers on
DGKH
What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review.
Review
New
London, United Kingdom. In Psychol Med, Sep 2015
Irrespective of imaging modality, studies addressing the effect of SZ/BD GWAS risk genes (ANK3, CACNA1C, MHC, TCF4, NRGN, DGKH, PBRM1, NCAN and ZNF804A) were included.
Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia.
New
Würzburg, Germany. In Eur Arch Psychiatry Clin Neurosci, Mar 2015
The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD).
Identification of lung cancer oncogenes based on the mRNA expression and single nucleotide polymorphism profile data.
In Neoplasma, 2014
Also, 39 common genes, like PFKP (phosphofructokinase, platelet) and DGKH-rs11616202 (diacylglycerol kinase, eta) that enriched in sub-pathways such as galactose metabolism, fructose and mannose metabolism, and pentose phosphate pathway, were identified as the lung cancer oncogenes.
Beneficial effect of phosphatidylcholine supplementation in alleviation of hypomania and insomnia in a Chinese bipolar hypomanic boy and a possible explanation to the effect at the genetic level.
Hong Kong, Hong Kong. In Springerplus, 2014
INTRODUCTION: Recent studies indicated that supplementation of phosphatidylcholine has been found to be beneficial for psychiatric diseases and Diacylglycerol Kinase, Eta (DGKH) protein was involved in regulating the metabolism of phosphatidic acid and diacylglycerol.
Association study of DGKH gene polymorphisms with calcium oxalate stone in Chinese population.
Guangzhou, China. In Urolithiasis, 2014
Diacylglycerol kinase eta (DGKH) participates in regulating the intracellular concentrations of two bioactive lipids, diacylglycerol and phosphatidic acid.
Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes.
El Paso, United States. In Brain Behav, 2014
BACKGROUND: Four of the most consistently replicated variants associated with mood disorder occur in genes important for synaptic function: ANK3 (rs10994336), BDNF (rs6265), CACNA1C (rs1006737), and DGKH (rs1170191).
Idiopathic calcium nephrolithiasis: a review of pathogenic mechanisms in the light of genetic studies.
Review
Milano, Italy. In Am J Nephrol, 2013
The renal activity of the last gene, DGKH, is unknown.
A systems biology approach using metabolomic data reveals genes and pathways interacting to modulate divergent growth in cattle.
Germany. In Bmc Genomics, 2012
Our data showed that GnRH (Gonadotropin-releasing hormone) signaling is associated with divergent growth at the onset of puberty and revealed two highly connected hubs, BTC and DGKH, within the network.
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
Boston, United States. In Plos Genet, 2012
Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase.
Effect of variation in diacylglycerol kinase η (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder.
GeneRIF
Edinburgh, United Kingdom. In Neuropsychopharmacology, 2012
Differential effects of DGKH in healthy controls vs the bipolar high-risk group manifest as a failure to disengage default-mode regions in those at familial risk carrying the risk haplotype.
Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: what have we learnt?
Review
Singapore, Singapore. In Neurosci Biobehav Rev, 2012
Risk genes associated with BPD include ankyrin 3, node of Ranvier (ANK3), calcium channel, voltage dependent, L type, alpha 1C subunit (CACNA1C), diacylglycerol kinase eta (DGKH), gene locus on chromosome 16p12, and polybromo-1 (PBRM1) and very recently neurocan gene (NCAN).
Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder.
Tulsa, United States. In Transl Psychiatry, 2011
In addition to pathway enrichment, the collective network approach elevates the importance of ANK3, DGKH and ODZ4 for BD susceptibility in the WTCCC GWAS, despite their weak single-locus effect in the data.
Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD.
GeneRIF
Würzburg, Germany. In Neuropsychopharmacology, 2011
Four DGKH markers are linked to adult attention-hyperactivity disorder and seven to unipolar depression, making DGKH a risk factor gene for bipolar disorder, unipolar depression and adult attention-deficit hyperactivity disorder.
Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population.
GeneRIF
In Mol Psychiatry, 2011
The results of tisd support DGKH as shared risk factor of bipolar disorder and schizophrenia in the Chinese Han population.
Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples.
GeneRIF
Fukuoka, Japan. In Psychiatry Clin Neurosci, 2011
Although the association was not strong, the result of this study would support the association between DGKH and BD.
Differential regulation of diacylglycerol kinase isoform in human failing hearts.
GeneRIF
Yamagata, Japan. In J Cardiothorac Surg, 2010
expressions of DGKeta and DGKzeta were increased and decreased, respectively, whereas those of DGKgamma and DGKepsilon remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts.
The genetics of bipolar disorder.
Review
Boston, United States. In Neuroscience, 2009
Nevertheless, genomewide association analysis, which has successfully identified susceptibility genes for a variety of complex disorders, has begun to implicate specific genes for bipolar disorder (DGKH, CACNA1C, ANK3).
Ameliorating prefrontal cortical dysfunction in mental illness: inhibition of phosphotidyl inositol-protein kinase C signaling.
Review
New Haven, United States. In Psychopharmacology (berl), 2009
For example, DAG kinase eta, an enzyme that metabolizes DAG and thus reduces protein kinase C activity, is the gene most altered in bipolar disorder.
