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Diacylglycerol kinase, theta 110kDa

DGK-theta, Dagk4, Diacylglycerol kinase-theta
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: THETA, ACID, fibrillin-1, RhoA, Akt
Papers on DGK-theta
Regulation of DGK-theta.
Review
Raben et al., Baltimore, United States. In J Cell Physiol, 2009
This review presents the progress on the characterization of a primarily neuronal isoform DGK-theta, and examines current data on the primary structure, regulation and potential cellular functions of this enzyme.
Nuclear diacylglycerol kinases: regulation and roles.
Review
Tu-Sekine et al., Baltimore, United States. In Front Biosci, 2007
In this review we focus primarily on the nuclear localization, modulation of intrinsic enzymatic activity, and the potential physiological roles of the six diacylglycerol kinases that have been found in the nucleus: DGK-alpha, DGK-gamma, DGK-delta, DGK-zeta, DGK-iota, and DGK-theta.
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
GeneRIF
Sewer et al., Atlanta, United States. In Mol Cell Biol, 2007
Data show that cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
Norepinephrine and endothelin activate diacylglycerol kinases in caveolae/rafts of rat mesenteric arteries: agonist-specific role of PI3-kinase.
Ohanian et al., Manchester, United Kingdom. In Am J Physiol Heart Circ Physiol, 2007
We show that components of the PI signaling cascade-phosphatidylinositol 4,5-bisphosphate (PIP(2)), PA, and DGK-theta are present in caveolae/rafts prepared from rat mesenteric small arteries.
Modulation of diacylglycerol kinase theta activity by alpha-thrombin and phospholipids.
Raben et al., Baltimore, United States. In Biochemistry, 2007
We examined the effects of alpha-thrombin and activating phospholipids on the activity and substrate affinity of a soluble diacylglycerol kinase, DGKtheta.
Analysis of a novel diacylglycerol kinase from Dictyostelium discoideum: DGKA.
Raben et al., Baltimore, United States. In Biochemistry, 2005
Recently, a protein that is significantly similar to human DGK-theta, DGKA, was identified in Dictyostelium discoideum.
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.
GeneRIF
van Blitterswijk et al., Amsterdam, Netherlands. In J Biol Chem, 2005
DGK interacts selectively with and is phosphorylated by PKCepsilon and -eta and peptide agonist-induced selective activation of PKCepsilon directly leads to DGK translocation
Nuclear diacylglycerol kinase-theta is activated in response to nerve growth factor stimulation of PC12 cells.
Martelli et al., Bologna, Italy. In Cell Signal, 2004
A DGK isoform, which resides in the nucleus of PC12 cells, is DGK-theta.
Structure-activity relationship of diacylglycerol kinase theta.
van Blitterswijk et al., Netherlands. In Biochim Biophys Acta, 2004
Among the nine mammalian isotypes identified, DGKtheta is the only one with three cysteine-rich domains (CRDs) (instead of two) in its N-terminal regulatory region.
Protein kinase C delta is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Terranova et al., Kansas City, United States. In Toxicology, 2004
PKCgamma, eta, theta and DGKtheta were not detected.
Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.
GeneRIF
Martelli et al., Bologna, Italy. In Exp Cell Res, 2003
Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles.
Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5.
Tankersley et al., Baltimore, United States. In J Appl Physiol, 2003
One gene in the interval, Dagk4 at 57 cM, is polymorphic for C3 and B6 mice.
Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.
Raben et al., Baltimore, United States. In J Biol Chem, 2001
The examination of nuclei isolated from quiescent IIC9 cells indicates that DGK-theta and DGK-delta are both present.
Diacylglycerol kinase theta is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries.
Ohanian et al., Manchester, United Kingdom. In Biochem J, 2001
Here, we have identified this DGK activity as DGKtheta, present in both smooth muscle and endothelial cells of these small vessels.
Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.
van Blitterswijk et al., Amsterdam, Netherlands. In J Biol Chem, 1999
We have previously identified the DGKtheta isotype, which is predominantly expressed in brain (Houssa, B., Schaap, D., van der Wal, J., Goto, K., Kondo, H., Yamakawa, A., Shibata, M., Takenawa, T., and Van Blitterswijk, W. J. (1997) J. Biol.
Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.
van Blitterswijk et al., Amsterdam, Netherlands. In J Biol Chem, 1997
The cDNA encodes a novel DGK isotype, termed DGKtheta, of 941 amino acids with an apparent molecular mass of 110 kDa.
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