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Diacylglycerol O-acyltransferase 2

DGAT2, diacylglycerol acyltransferase 2
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Diacylglycerol O-Acyltransferase, ACID, STEP, HAD, Insulin
Papers on DGAT2
DGAT2 Mutation in a Family with Autosomal Dominant Early-Onset Axonal Charcot-Marie-Tooth Disease.
Chung et al., Seoul, South Korea. In Hum Mutat, Feb 2016
Pedigree analysis and exome sequencing identified a de novo missense mutation (p.Y223H) in the diacylglycerol O-acyltransferase 2 (DGAT2) gene.
Lipid metabolism and the risk factors of cardiovascular disease: implication of dietary omega-3 polyunsaturated fatty acids.
Balogun, St. John's, Canada. In Appl Physiol Nutr Metab, Feb 2016
High n-3 PUFA diet also led to the downregulation of the messenger RNA expression of acyl-CoA:diacylglycerol acyltransferase 2, fatty acid binding protein-4, peroxisome proliferator-activated receptor protein γ, and leptin in males, which are key proteins involved in adipocyte hypertrophy; however, no effect was observed in females.
Four new sesqui-lignans isolated from Acanthopanax senticosus and their diacylglycerol acyltransferase (DGAT) inhibitory activity.
Cui et al., Taiwan. In Fitoterapia, Feb 2016
All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2.
Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations.
Lin et al., Shanghai, China. In Hum Mol Genet, Feb 2016
Four novel loci (MYB, AGPAT4, DGAT2 and PPT2) reached genome-wide significance in the trans-ethnic meta-analysis (log10(Bayes Factor)≥6).
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells.
Moreau et al., Lincoln, United States. In Biochim Biophys Acta, Jan 2016
mTORC1 hyperactivation induced the expression of lipogenic (DGAT1 and DGAT2) and lipoprotein assembly (MTP and APOB) genes, thereby raising cellular triacylglyceride (TG) and exacerbating secretion of apoB-containing TG-rich lipoproteins.
Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy.
Tanaka et al., Matsumoto, Japan. In Bba Clin, Jun 2015
RESULTS: The livers of post-PD NASH patients demonstrated significant up-regulation of the genes encoding CD36, FA-binding proteins 1 and 4, acetyl-coenzyme A carboxylase α, diacylglycerol acyltransferase 2, and peroxisome proliferator-activated receptor (PPAR) γ compared with normal and conventional NASH livers.
Two Predicted Transmembrane Domains Exclude Very Long Chain Fatty acyl-CoAs from the Active Site of Mouse Wax Synthase.
Feussner et al., Göttingen, Germany. In Plos One, 2014
In order to get insights into the structure-function relationships of a wax synthase from Mus musculus, a domain swap experiment between the mouse acyl-CoA:wax alcohol acyltransferase (AWAT2) and the homologous mouse acyl-CoA:diacylglycerol O-acyltransferase 2 (DGAT2) was performed.
Mechanism of Butyrate Stimulation of Triglyceride Storage and Adipokine Expression during Adipogenic Differentiation of Porcine Stromovascular Cells.
Ajuwon et al., West Lafayette, United States. In Plos One, 2014
Results show that butyrate treatment enhanced adipogenesis and lipid accumulation, perhaps through upregulation of glucose uptake and de novo lipogenesis and other mechanisms that include induction of SREBP-1c, C/EBPα/β, GLUT4, LPL, PPARγ, GPAT4, DGAT1 and DGAT2 expression.
The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease.
Chapados et al., Ottawa, Canada. In J Diabetes Metab Disord, 2014
Seven days later, liver triglycerides (TAG) content was measured along with protein quantification of hepatic microsomal triglyceride transfer protein (MTP), sterol regulatory element-binding protein 1c (SREBP1c) and diacylglycerol O-acyltransferase 2 (DGAT-2).
Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors.
Lee et al., Seoul, South Korea. In Chemmedchem, 2014
It has two isoforms, DGAT-1 and DGAT-2, which are widely expressed and present in white adipose tissue.
Recent advances in niacin and lipid metabolism.
Kashyap et al., Long Beach, United States. In Curr Opin Lipidol, 2013
RECENT FINDINGS: Emerging findings indicate that niacin decreases hepatic triglyceride synthesis and subsequent VLDL/LDL secretion by directly and noncompetitively inhibiting hepatocyte diacylglycerol acyltransferase 2. Recent studies in mice lacking niacin receptor GPR109A and human clinical trials with GPR109A agonists disproved the long believed hypothesis of adipocyte triglyceride lipolysis as the mechanism for niacin's effect on serum lipids.
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.
Zammit, Coventry, United Kingdom. In Biochem J, 2013
Recent observations on the specialised role of DGAT2 (diacylglycerol acyltransferase 2) in catalysing the de novo synthesis of triacylglycerols from newly synthesized fatty acids and nascent diacylglycerols identifies this enzyme as the link between the two.
Acyl-CoA:diacylglycerol acyltransferase: molecular biology, biochemistry and biotechnology.
Weselake et al., Edmonton, Canada. In Prog Lipid Res, 2012
catalyzes the final step in the sn-glycerol-3-phosphate pathway leading to TG. DGAT activity resides mainly in two distinct membrane bound polypeptides, known as DGAT1 and DGAT2 which have been identified in numerous organisms.
Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells.
Zammit et al., Coventry, United Kingdom. In Febs J, 2012
describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1
Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.
Ason et al., San Francisco, United States. In J Lipid Res, 2012
role of Mtp and DGAT2 in hepatic steatosis
Liver fat reduction with niacin is influenced by DGAT-2 polymorphisms in hypertriglyceridemic patients.
Tomlinson et al., Hong Kong, Hong Kong. In J Lipid Res, 2012
Niacin treatment may reduce liver fat content in Chinese patients with dyslipidemia and the mechanism may involve inhibition of DGAT2.
Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum.
Stone et al., Saskatoon, Canada. In J Biol Chem, 2011
DGAT2 is capable of catalyzing TG synthesis and promote its storage in cytosolic lipid droplets independent of its localization in the ER.
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2.
Shulman et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2011
DAG-induced PKCepsilon activation plays a major role in nonalcoholic fatty liver disease (NAFLD)-associated hepatic insulin resistance.
Molecular pathways and agents for lowering LDL-cholesterol in addition to statins.
Costet, Nantes, France. In Pharmacol Ther, 2010
We will identify important or rate-limiting proteins (including Niemann-Pick C1-like 1 (NPC1L1), microsomal TG transfer protein (MTP), acyl-coenzyme A/cholesterol acyltransferase (ACAT), Acyl-CoA:diacylglycerol acyltransferases 2 (DGAT2), proprotein convertase subtilisin kexin type 9 (PCSK9)), and nuclear receptors (farnesoid X receptor (FXR), thyroid hormone receptor (TR)) that constitute interesting therapeutic targets.
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
Farese et al., San Francisco, United States. In Cell Metab, 2007
To test the causal relationship between hepatic steatosis and insulin resistance, we generated mice that overexpress acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2), which catalyzes the final step of triacylglycerol (TG) biosynthesis, in the liver (Liv-DGAT2 mice).
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