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Desmoglein 3

Desmoglein 3, Dsg3
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Desmoglein 1, CAN, Phosphogluconate Dehydrogenase, HAD, PKG
Papers using Desmoglein 3 antibodies
Protection of neonates against pemphigus foliaceus by desmoglein 3
Supplier
Stanley John R. et al., In The Journal of Cell Biology, 1999
... PCR primers from desmoglein 3 exon 7 (5′-AACTTCCCAGTGCTCAGAGAGTCTC-3′) and exon 8 (5′-TTAACCACCTTCAGGATGCCTTC-3′) were used to identify genomic DNA (671-bp product) or transgenic cDNA (213-bp product) (see ...
Papers on Desmoglein 3
Diagnostic performance of the "MESACUP anti-Skin profile TEST".
New
Sárdy et al., Budapest, Hungary. In Eur J Dermatol, Feb 2016
UNASSIGNED: The "MESACUP anti-Skin profile TEST" test is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays.
Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Tissue from Patients with Pemphigus Vulgaris.
New
Kowalczyk et al., Atlanta, United States. In J Invest Dermatol, Jan 2016
Pemphigus vulgaris (PV) is an autoimmune epidermal blistering disease in which autoantibodies (IgG) are directed against the desmosomal cadherin desmoglein 3. To better understand how PV IgG alters desmosome morphology and function in vivo, biopsies from patients with PV were analyzed by structured illumination microscopy, a form of superresolution fluorescence microscopy.
Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.
New
Waschke et al., München, Germany. In J Invest Dermatol, Jan 2016
The desmosomal transmembrane adhesion molecules desmoglein 3 (Dsg3) and desmocollin 3 (Dsc3) are required for strong keratinocyte cohesion.
Interleukin 4 inhibition as a potential therapeutic in pemphigus.
New
Tavakolpour et al., Tehrān, Iran. In Cytokine, Jan 2016
Pemphigus is an autoimmune bullous skin disease that results from desmosomal protein desmoglein 3 and 1 loss in pemphigus vulgaris and foliaceus, respectively.
Annexin A8 is a novel molecular marker for detecting lymph node metastasis in oral squamous cell carcinoma.
New
Hamakawa et al., Japan. In Oncotarget, Jan 2016
Of 4 genes identified by microarray analysis, annexin A8 (ANXA8) and desmoglein 3 mRNA were detected by qRT-PCR in metastatic lymph nodes but not in normal lymph nodes.
Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.
New
Eming et al., Marburg an der Lahn, Germany. In Exp Dermatol, Jan 2016
Its pathogenesis is based on IgG autoantibodies that target the desmosomal cadherins, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1) and induce intraepidermal loss of adhesion.
Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.
New
Knösel et al., München, Germany. In Br J Cancer, Dec 2015
METHODS: Using immunohistochemistry, we examined desmoglein 1 (DSG1), desmoglein 2 (DSG2) and desmoglein 3 (DSG3) expression in the tumour tissue of 165 resected PDAC cases.
Epithelial antigenic specificities of circulating autoantibodies in mucosal lichen planus.
New
Martínez Escala et al., Barcelona, Spain. In Int J Dermatol, Dec 2015
METHODS: We tested a series of consecutive cases of mucosal LP in our clinic by enzyme-linked immunosorbent assay using desmoglein 3 (Dsg3) and BP180 fusion proteins.
Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.
New
Waschke et al., München, Germany. In J Invest Dermatol, Oct 2015
UNASSIGNED: The desmosomal transmembrane adhesion molecules desmoglein 3 (Dsg3) and desmocollin 3 (Dsc3) are required for strong keratinocyte cohesion.
Rituximab therapy improves recalcitrant Pemphigus vulgaris.
Sadeghinia et al., Tehrān, Iran. In Excli J, 2014
Pemphigus disease activity index (PDAI), anti-desmoglein 1 and anti-desmoglein 3 antibody titers, and percent of CD20 positive cells were measured at baseline, 10 ± 1, and 22 ± 2 weeks after rituximab therapy.
Desmoglein 3: a help or a hindrance in cancer progression?
Review
Wan et al., London, United Kingdom. In Cancers (basel), 2014
Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes.
Japanese guidelines for the management of pemphigus.
Review
Kitajima et al., In J Dermatol, 2014
Pemphigus has been defined as a group of intractable autoimmune blistering diseases caused by anti-desmoglein 1 and/or anti-desmoglein 3 IgG autoantibodies by the MHLW.
Pemphigus herpetiformis: from first description until now.
Review
Jabłońska et al., Lübeck, Germany. In J Am Acad Dermatol, 2014
The target autoantigen is usually desmoglein 1 (or less frequently desmoglein 3), although recently it has become increasingly obvious that patients with pemphigus herpetiformis also demonstrate autoantibodies against desmocollin.
Desmosomal adhesion and pemphigus vulgaris: the first half of the story.
Review
Al-Jandan et al., Melbourne, Australia. In Cell Commun Adhes, 2013
Cloning of the DSG3 gene, generation DSG3 knock-out mice and isolation of monoclonal anti-Dsg3 IgG have aided to clarify the pathogenic mechanisms of PV, which are in part dependent on the fate of desmosomal molecules.
Diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) to detect anti-skin autoantibodies in autoimmune blistering skin diseases: a systematic review and meta-analysis.
Review
Bizzaro et al., Bari, Italy. In Autoimmun Rev, 2012
AIM: To estimate the diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) to detect anti-BP180 and anti-desmoglein 3 (Dsg3) autoantibodies in the diagnosis of autoimmune blistering skin diseases.
Desmoglein-3 and Napsin A double stain, a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes.
GeneRIF
Kaya et al., Ankara, Turkey. In Appl Immunohistochem Mol Morphol, 2012
a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes
Differential IgG recognition of desmoglein 3 by paraneoplastic pemphigus and pemphigus vulgaris sera.
GeneRIF
Müller et al., In J Invest Dermatol, 2012
In paraneoplastic pempigus and pemphigus vulgaris, IgG autoantibodies to DSG3 may be found in autoantibody profiling.
Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.
GeneRIF
Wan et al., London, United Kingdom. In J Pathol, 2012
These findings suggest a novel function for Dsg3 in the control of E-cadherin-Src signalling and cell-cell adhesion.
Desmoglein as a target in skin disease and beyond.
GeneRIF
Stanley et al., Tokyo, Japan. In J Invest Dermatol, 2012
The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases.
Mapping of B cell epitopes on desmoglein 3 in pemphigus vulgaris patients by the use of overlapping peptides.
GeneRIF
Schmidt et al., Lübeck, Germany. In J Dermatol Sci, 2012
Report mapping of B cell epitopes on desmoglein 3 in pemphigus vulgaris patients by the use of overlapping peptides.
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