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Desmoglein 2

Desmoglein 2, Dsg2
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Armadillo, PKG, E-cadherin, CAN, DSP
Papers using Desmoglein 2 antibodies
Qupe–a Rich Internet Application to take a step forward in the analysis of mass spectrometry-based quantitative proteomics experiments
Dettman Robert, In PLoS ONE, 2008
... To generate plasmids coding for DSG2-EC1-4-Arg-Gly-Ser(RGS)-6xHis, fl-DSG2 and fl-DSC2b cDNA were amplified with appropriate primers (Table S1) and subcloned into pLPCX (Clontech) or pEYFP-N1 (Clontech) ...
Papers on Desmoglein 2
Loss of plakoglobin immunoreactivity in intercalated discs in arrhythmogenic right ventricular cardiomyopathy: Protein mislocalization versus epitope masking.
Leube et al., Aachen, Germany. In Cardiovasc Res, Jan 2016
METHODS AND RESULTS: Normalized semiquantitative immunofluorescence measurements were performed in a standardized format in desmoglein 2-mutant mice with an ARVC-like phenotype (n=6) and in cardiac biopsies from humans with ARVC and non-ARVC heart disease (n=10).
Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis.
Monga et al., Xi'an, China. In Am J Pathol, Dec 2015
Enhanced association of β-catenin to desmoglein-2 and plakophilin-3 was observed in KO.
Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.
Knösel et al., München, Germany. In Br J Cancer, Dec 2015
METHODS: Using immunohistochemistry, we examined desmoglein 1 (DSG1), desmoglein 2 (DSG2) and desmoglein 3 (DSG3) expression in the tumour tissue of 165 resected PDAC cases.
Intracellular Signaling and Desmoglein 2 Shedding Triggered by Human Adenoviruses Ad3, Ad14, and Ad14P1.
Lieber et al., Seattle, United States. In J Virol, Nov 2015
UNLABELLED: We recently discovered that desmoglein 2 (DSG2) is a receptor for human adenovirus species B serotypes Ad3, Ad7, Ad11, and Ad14.
High-throughput genetic characterization of a cohort of Brugada syndrome patients.
Benedetti et al., Milano, Italy. In Hum Mol Genet, Nov 2015
We confirmed BrS genetic heterogeneity and identified new potential BrS candidates such as DSG2 and MYH7, suggesting a possible genetic overlap between different cardiac disorders.
Three-dimensional co-culture of BM-MSCs and eccrine sweat gland cells in Matrigel promotes transdifferentiation of BM-MSCs.
Fu et al., Shantou, China. In J Mol Histol, Oct 2015
We co-cultured BrdU-labeled bone marrow-derived mesenchymal stem cells (BM-MSCs) and eccrine sweat gland cells in Matrigel for 2 weeks in vitro and then evaluated for BM-MSCs differentiation into functional eccrine sweat gland cells by morphological assessment and immunohistochemical double staining for BrdU/pancytokeratin, BrdU/ZO-2, BrdU/E-cadherin, BrdU/desmoglein-2, BrdU/Na(+)-K(+)-ATPase α, BrdU/NHE1 and BrdU/CFTR.
Mutations of desmoglein-2 in sudden death from arrhythmogenic right ventricular cardiomyopathy and sudden unexplained death.
Burke et al., Shanghai, China. In Forensic Sci Int, Oct 2015
Desmoglein-2 (DSG2), a member of the desmosomal cadherin superfamily, has been linked to arrhythmogenic right ventricular cardiomyopathy (ARVC)which may cause life-threatening ventricular arrhythmias and sudden death.
Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier.
Nusrat et al., Sapporo, Japan. In Mol Biol Cell, Oct 2015
Here we describe the proinflammatory cytokine-induced activation of matrix metalloproteinase 9 and a disintegrin and metalloproteinase domain-containing protein 10, which promote the shedding of desmosomal cadherin desmoglein-2 (Dsg2) ectodomains in intestinal epithelial cells.
Alzheimer's disease risk genes and mechanisms of disease pathogenesis.
Goate et al., Saint Louis, United States. In Biol Psychiatry, 2015
More recent advances in understanding of the human genome-technologic advances in methods to analyze millions of polymorphisms in thousands of subjects-have revealed new genes associated with AD risk, including ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-DBR1, INPP5D, MS4A, MEF2C, NME8, PICALM, PTK2B, SLC24H4-RIN3, SORL1, and ZCWPW1.
Genetic Analysis of Arrhythmogenic Diseases in the Era of NGS: The Complexity of Clinical Decision-Making in Brugada Syndrome.
Brugada et al., Girona, Spain. In Plos One, 2014
Twenty-eight genes were resequenced: AKAP9, ANK2, CACNA1C, CACNB2, CASQ2, CAV3, DSC2, DSG2, DSP, GPD1L, HCN4, JUP, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, KCNQ1, NOS1AP, PKP2, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SNTA1, and TMEM43.
From prediction to experimental validation: desmoglein 2 is a functionally relevant substrate of matriptase in epithelial cells and their reciprocal relationship is important for cell adhesion.
Venkatraman et al., Mumbai, India. In Biochem J, 2012
Dsg-2 with a mutation at the predicted cleavage site is resistant to cleavage by matriptase. Thus Dsg-2 seems to be a functionally relevant physiological substrate of matriptase.
Adenovirus receptors: implications for targeting of viral vectors.
Arnberg, Umeå, Sweden. In Trends Pharmacol Sci, 2012
The numerous interactions of different adenoviruses with host molecules - such as the recently identified desmoglein-2 receptor - may cause novel and unexpected obstacles, but also may provide possibilities for vectors based on alternative types.
Histological and ultrastructural abnormalities in murine desmoglein 2-mutant hearts.
Krusche et al., Aachen, Germany. In Cell Tissue Res, 2012
Mutant desmoglein 2 cannot support the increased requirements placed on intercalated disc adhesion during postnatal heart development. This induces cardiomyocyte death, aseptic inflammation and fibrotic replacement.
Mutations with pathogenic potential in proteins located in or at the composite junctions of the intercalated disk connecting mammalian cardiomyocytes: a reference thesaurus for arrhythmogenic cardiomyopathies and for Naxos and Carvajal diseases.
Pieperhoff et al., Heidelberg, Germany. In Cell Tissue Res, 2012
As the pertinent literature is still in an expanding phase and is obviously becoming important for various groups of researchers in basic cell and molecular biology, developmental biology, histology, physiology, cardiology, pathology and genetics, the relevant references so far recognized have been collected and are presented here in the following order: desmocollin-2 (Dsc2, DSC2), desmoglein-2 (Dsg2, DSG2), desmoplakin (DP, DSP), plakoglobin (PG, JUP), plakophilin-2 (Pkp2, PKP2) and some non-desmosomal proteins such as transmembrane protein 43 (TMEM43), ryanodine receptor 2 (RYR2), desmin, lamins A and C, striatin, titin and transforming growth factor-β3 (TGFβ3), followed by a collection of animal models and of reviews, commentaries, collections and comparative studies.
Pathophysiology of arrhythmogenic cardiomyopathy.
Thiene et al., Padova, Italy. In Nat Rev Cardiol, 2012
Mutations in five genes that encode major components of the desmosomes, namely junction plakoglobin, desmoplakin, plakophilin-2, desmoglein-2, and desmocollin-2, have been identified in approximately half of affected probands.
Desmoglein as a target in skin disease and beyond.
Stanley et al., Tokyo, Japan. In J Invest Dermatol, 2012
Desmoglein 2, expressed earliest among the four isoforms in development, was found to be mutated in arrythmogenic right ventricular cardiomyopathy and is a receptor for a subset of adenoviruses that cause respiratory and urinary tract infections.
Gastro-oesophageal reflux disease is associated with up-regulation of desmosomal components in oesophageal mucosa.
Malfertheiner et al., Magdeburg, Germany. In Histopathology, 2012
Induced gene expression levels of plakoglobin, desmoglein-1 and desmoglein-2 correlated significantly with dilatation of intercellular spaces and basal cell hyperplasia in esophageal mucosa of patients with gastro-oesophageal reflux disease.
Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes.
Green et al., Chicago, United States. In J Cell Biol, 2012
The Dsg2 exhibit microtubule-dependent transport in epithelial cells but use distinct motors to traffic to the plasma membrane.
Arrhythmogenic right ventricular cardiomyopathy/dysplasia: a review and update.
Erbel et al., Essen, Germany. In Clin Res Cardiol, 2011
Dysfunctional desmosomes resulting in defective cell adhesion proteins, such as plakoglobin (JUP), desmoplakin (DSP), plakophilin-2 (PKP-2), and desmoglein-2 (DSG-2) consequently cause loss of electrical coupling between cardiac myocytes, leading to myocyte cell death, fibrofatty replacement and arrhythmias.
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.
Lieber et al., Seattle, United States. In Nat Med, 2011
We have identified desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14.
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