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Desmoglein 1

Desmoglein 1, Dsg1
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Desmoglein 3, Phosphogluconate Dehydrogenase, HAD, PKG, CAN
Papers on Desmoglein 1
Diagnostic performance of the "MESACUP anti-Skin profile TEST".
New
Sárdy et al., Budapest, Hungary. In Eur J Dermatol, Feb 2016
UNASSIGNED: The "MESACUP anti-Skin profile TEST" test is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays.
Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.
New
Eming et al., Marburg an der Lahn, Germany. In Exp Dermatol, Jan 2016
Its pathogenesis is based on IgG autoantibodies that target the desmosomal cadherins, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1) and induce intraepidermal loss of adhesion.
Donor-derived stem-cells and epithelial mesenchymal transition in squamous cell carcinoma in transplant recipients.
New
Janin et al., Paris, France. In Oncotarget, Jan 2016
In these areas, the expressions of claudin-1 and desmoglein 1 were reduced or absent, and within the basal layer there were features of basal membrane disappearance.Donor-derived stem cells were in larger numbers in stem cells co-expressing vimentin or snail and slug than in stem cells not expressing any EMT marker.
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
New
Magin et al., Leipzig, Germany. In J Cell Biol, Jan 2016
Comparative proteomics of cornified envelopes (CEs) from prenatal KtyI(-/-) and KtyII(-/-) K8 mice demonstrates that absence of KIF causes dysregulation of many CE constituents, including downregulation of desmoglein 1.
Quality of Life Assessment in Korean Patients with Pemphigus.
New
Kim et al., Seoul, South Korea. In Ann Dermatol, Oct 2015
The DLQI score highly correlated with disease severity, titer of anti-desmoglein 1 in enzyme-linked immunosorbent assay, and the corticosteroid dose.
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Review
Schwartz et al., Newark, United States. In J Eur Acad Dermatol Venereol, 2014
The aetiological exfoliating toxin is a serine protease that splits only desmoglein 1.
Japanese guidelines for the management of pemphigus.
Review
Kitajima et al., In J Dermatol, 2014
Pemphigus has been defined as a group of intractable autoimmune blistering diseases caused by anti-desmoglein 1 and/or anti-desmoglein 3 IgG autoantibodies by the MHLW.
Genetic skin diseases related to desmosomes and corneodesmosomes.
Review
Igawa et al., Asahikawa, Japan. In J Dermatol Sci, 2014
Other types of genetic defects in a desmosome component (desmoglein 1), a corneodesmosome component (corneodesmosin), and an inhibitor for proteases involved in corneodesmosome degradation (LEKTI) result in three clinically overlapping conditions: SAM syndrome, an inflammatory type of peeling skin disease, and Netherton syndrome.
Pemphigus herpetiformis: from first description until now.
Review
Jabłońska et al., Lübeck, Germany. In J Am Acad Dermatol, 2014
The target autoantigen is usually desmoglein 1 (or less frequently desmoglein 3), although recently it has become increasingly obvious that patients with pemphigus herpetiformis also demonstrate autoantibodies against desmocollin.
Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.
Impact
Sprecher et al., Tel Aviv-Yafo, Israel. In Nat Genet, 2013
DSG1 encodes desmoglein 1, a major constituent of desmosomes, which connect the cell surface to the keratin cytoskeleton and have a crucial role in maintaining epidermal integrity and barrier function.
Netherton syndrome: skin inflammation and allergy by loss of protease inhibition.
Review
Hovnanian, Paris, France. In Cell Tissue Res, 2013
One results in desmoglein 1 degradation and desmosome cleavage leading to stratum corneum detachment.
Cutting Edge: Brazilian pemphigus foliaceus anti-desmoglein 1 autoantibodies cross-react with sand fly salivary LJM11 antigen.
GeneRIF
Diaz et al., Chapel Hill, United States. In J Immunol, 2012
we show that the LJM11 salivary protein from the sand fly are recognized by pemphigus foliaceus autoantibodies against desmoglein 1
Desmoglein as a target in skin disease and beyond.
Review
GeneRIF
Stanley et al., Tokyo, Japan. In J Invest Dermatol, 2012
The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases.
Gastro-oesophageal reflux disease is associated with up-regulation of desmosomal components in oesophageal mucosa.
GeneRIF
Malfertheiner et al., Magdeburg, Germany. In Histopathology, 2012
Induced gene expression levels of plakoglobin, desmoglein-1 and desmoglein-2 correlated significantly with dilatation of intercellular spaces and basal cell hyperplasia in esophageal mucosa of patients with gastro-oesophageal reflux disease.
Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris.
GeneRIF
Amagai et al., Tokyo, Japan. In J Dermatol Sci, 2011
Transgenic expression of Dsg1 rescued the severe B6-Dsg3(-/-) phenotype and provided a syngeneic mouse model of pemphigus vulgaris.
IgE, IgM, and IgG4 anti-desmoglein 1 autoantibody profile in endemic pemphigus foliaceus (fogo selvagem).
GeneRIF
Cooperative Group on Fogo Selvagem Research et al., In J Invest Dermatol, 2011
anti-DSG1 response in fogo selvagem patients may be initiated by sensitization to an environmental allergen
The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
Impact
Tansey et al., New York City, United States. In Cell, 2005
Destruction of transcriptionally active Gal4 depends on an F box protein called Dsg1/Mdm30.
Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity.
Impact
Hovnanian et al., Toulouse, France. In Nat Genet, 2005
LEKTI deficiency causes abnormal desmosome cleavage in the upper granular layer through degradation of desmoglein 1 due to stratum corneum tryptic enzyme and stratum corneum chymotryptic enzyme-like hyperactivity.
Prospects for autoimmune disease: Research advances in pemphigus.
Impact
Diaz et al., Baltimore, United States. In Jama, 2001
This article discusses the precise structure of the major histocompatibility complex class II gene-peptide-T-cell receptor complex involved and of the environmental and genetic factors that induce autoimmunity against desmoglein 1. Discovery of antigen-specific immunotherapy and insight into environmental factors that initiate autoimmunity in genetically susceptible individuals are needed.
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1.
Impact
Stanley et al., Tokyo, Japan. In Nat Med, 2000
Desmoglein (Dsg) 1, a desmosomal cadherin that mediates cell-cell adhesion, may be the target of exfoliative toxin A, because it is the target of autoantibodies in pemphigus foliaceus, in which blisters form with identical tissue specificity and histology.
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