Diagnostic performance of the "MESACUP anti-Skin profile TEST".
Budapest, Hungary. In Eur J Dermatol, Feb 2016
UNASSIGNED: The "MESACUP anti-Skin profile TEST" test is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays.
Recent research advances in eosinophilic esophagitis.
Boston, United States. In Curr Opin Pediatr, Dec 2015
Epithelial barrier protein desmoglein 1, bone morphogenetic protein antagonist follistatin, neurotrophic tyrosine kinase receptor type 1, and CAPN14 have been defined as new potential therapeutic targets in EoE as regulators of the inflammatory interleukin-13-axis.
Pemphigus in the Arab world.
Cairo, Egypt. In J Dermatol, 2015
The presence of anti-desmoglein 1 antibodies in the sera of normal Tunisians and the presence of anti-desmoglein 3 in normal Egyptians' sera suggested that environmental factors played a role in the disease pathogenesis in those areas.
Update on fogo selvagem, an endemic form of pemphigus foliaceus.
São Paulo, Brazil. In J Dermatol, 2015
Endemic pemphigus foliaceus or fogo selvagem (FS) is one of the variants of pemphigus foliaceus pemphigus foliaceus that shares the same clinical and immunopathological features of the classic non-endemic pemphigus foliaceus form, including pathogenic IgG (mainly IgG4) autoantibodies directed against the ectodomain of desmoglein 1 (Dsg1), that lead to acantholysis.
Desmoglein as a target in skin disease and beyond.
Tokyo, Japan. In J Invest Dermatol, 2012
The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases.
Prospects for autoimmune disease: Research advances in pemphigus.
Baltimore, United States. In Jama, 2001
This article discusses the precise structure of the major histocompatibility complex class II gene-peptide-T-cell receptor complex involved and of the environmental and genetic factors that induce autoimmunity against desmoglein 1. Discovery of antigen-specific immunotherapy and insight into environmental factors that initiate autoimmunity in genetically susceptible individuals are needed.