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Degenerative spermatocyte homolog 2

DES2, sphingolipid Delta4-desaturase/C-4-hydroxylase
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: des-1, HAD, CAN, delta4, RIC
Papers on DES2
The Effect of Temperature on Kinetics and Diffusion Coefficients of Metallocene Derivatives in Polyol-Based Deep Eutectic Solvents.
Brandon et al., Kuala Lumpur, Malaysia. In Plos One, 2014
The temperature dependence of the measured conductivities of DES1 and DES2 are better correlated with the Vogel-Tamman-Fulcher equation.
Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.
Separovic et al., Vancouver, Canada. In J Photochem Photobiol B, 2013
The results revealed that PDT induced an upregulation in the expression of two major isoforms of both genes (DES1 and DES2 as well as SPHK1 and SPHK2).
Comparison of the safety between first- and second-generation drug eluting stents: meta-analysis from 19 randomized trials and 16,924 patients.
Sendón et al., Madrid, Spain. In Int J Cardiol, 2012
Second generation drug eluting stent, DES-2 has been developed to optimize the results of percutaneous coronary intervention in terms of efficacy and safety, for avoiding early and late ST.
Effects of auxins on sorgoleone accumulation and genes for sorgoleone biosynthesis in sorghum roots.
Park et al., Taejŏn, South Korea. In J Agric Food Chem, 2012
In this study, five different sorgoleone biosynthetic genes were observed, namely DES2, DES3, ARS1, ARS2, and OMT3, which are upregulated in response to IAA, IBA, and NAA.
Dihydroceramide-based response to hypoxia.
GeneRIF
Petrache et al., Indianapolis, United States. In J Biol Chem, 2011
overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia
Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus.
Sigel et al., Bern, Switzerland. In Mol Pharmacol, 2010
H. contortus DEG-3/DES-2 receptors were functionally expressed in Xenopus laevis oocytes and were found to be preferentially activated by choline, to permeate monovalent cations, and to a smaller extent, calcium ions.
A revisitation of distractive-extension injuries of the subaxial cervical spine: a cadaveric and radiographic soft tissue analysis.
Anderson et al., Hong Kong, Hong Kong. In Spine (phila Pa 1976), 2010
SUMMARY OF BACKGROUND DATA: Two DE stages (DES) of injury to the cervical spine have been described as follows: DES-1 and DES-2.
Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors.
Treinin et al., Jerusalem, Israel. In Biochemistry, 2010
Here we show that coexpression with RIC-3 increases the level of surface expression of DEG-3 while slightly reducing the level of surface expression of DES-2, both subunits of the DEG-3/DES-2 nAChRs.
Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation.
Rioux et al., Rennes, France. In Biochimie, 2007
In mammals, two gene isoforms named DES1 and DES2 have recently been identified.
Dual effect of acid pH on purinergic P2X3 receptors depends on the histidine 206 residue.
Illes et al., Leipzig, Germany. In J Biol Chem, 2007
Further, a low pH value increased the activation time constant (tau(on)) of the alpha,beta-meATP current; the fast and slow time constants of desensitization (tau(des1), tau(des2)) were at the same time also increased.
Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.
GeneRIF
Suzuki et al., Wako, Japan. In Biochem J, 2006
the hydroxylation of dihydroceramide: sphinganine C-4 requires complex formation between Des2 and mb5 via their membrane-spanning domains and electron transfer from NADH to the substrate via the reduction of mb5 by b5R
Changes in esophageal motility after porfimer sodium photodynamic therapy for Barrett's dysplasia and mucosal carcinoma.
DeVault et al., Jacksonville, United States. In Dis Esophagus, 2005
Therefore, abnormal motility was present in 19 of 41 (46%) patients after PDT (DES-2, IEM-14, Aperistalsis-3).
RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains.
Treinin et al., Jerusalem, Israel. In J Biol Chem, 2005
In Caenorhabditis elegans RIC-3 is needed for functional expression of multiple nAChRs, including the DEG-3/DES-2 nAChR.
Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2.
Suzuki et al., Wako, Japan. In Febs Lett, 2004
Although the amino acid sequences of mouse DES1 (MDES1) and DES2 (MDES2) have 63% sequence identity, their enzymatic characteristics are quite different.
DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine.
GeneRIF
Suzuki et al., Wako, Japan. In Biochem J, 2004
DES2 is the dihydroceramide C-4 hydroxylase responsible for the biosynthesis of enriched phytosphingoglycolipids in the microvillous membranes of intestinal epithelial cells
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation.
GeneRIF
Igarashi et al., Sapporo, Japan. In Febs Lett, 2004
DES2 was identified and its up-regulation followed during keratinocyte differentiation.
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function.
Takeda et al., Ōsaka, Japan. In J Clin Invest, 2003
A desaturase isoenzyme, DES-1, prefers desaturation, but DES-2 catalyzes both reactions to a similar extent.
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