The complexity of sphingolipid biosynthesis in the endoplasmic reticulum.
Israel. In Biochim Biophys Acta, 2013
The initial steps of sphingolipid synthesis, from the activity of serine palmitoyltransferase through to dihydroceramide desaturase, take place in the endoplasmic reticulum, but the further metabolism of ceramide to sphingomyelin and complex glycosphingolipids takes place mostly in the Golgi apparatus.
Allosteric activation of DegS, a stress sensor PDZ protease.
Cambridge, United States. In Cell, 2007
When protein folding is compromised in the periplasm of E. coli, the C termini of outer-membrane proteins (OMPs) bind to the PDZ domains of the trimeric DegS protease and activate cleavage of RseA, a transmembrane transcriptional regulator.
A PDZ switch for a cellular stress response.
Heidelberg, Germany. In Cell, 2004
The accumulation of misfolded porins in the periplasm of bacteria triggers a proteolytic cascade, initiated by activation of DegS, a member of the family of HtrA proteases.