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Der1-like domain family, member 1

Derlin-1, Der1p, Der1, Der I
Top mentioned proteins: Ubiquitin, HRD1, ATPase, HAD, Sec61
Papers on Derlin-1
The effects of induced production of reactive oxygen species in organelles on endoplasmic reticulum stress and on the unfolded protein response in arabidopsis.
New
Turkan et al., İzmir, Turkey. In Ann Bot, Sep 2015
The expression of ER stress sensor/transducer genes (bZIP28, bZIP17, IRE1A, IRE1B, BiP1, BiP3), genes related to protein folding (CNX, ERO1) and ERAD genes (HRD1, SEL1, DER1, UBC32) were evaluated by qRT-PCR analysis.
Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.
Kakizawa et al., Kyoto, Japan. In Dev Biol, 2014
Calumin co-immunoprecipitated with ERAD components such as p97, BIP, derlin-1, derlin-2 and VIMP, suggesting its involvement in ERAD.
Strigolactone analog GR24 triggers changes in PIN2 polarity, vesicle trafficking and actin filament architecture.
Koltai et al., Israel. In New Phytol, 2014
We also recorded the response to GR24 of trafficking (tir3), actin (der1) and PIN2 (eir1) mutants.
Comparison of intracellular and secretion-based strategies for production of human α-galactosidase A in the filamentous fungus Trichoderma reesei.
Saloheimo et al., In Bmc Biotechnol, 2013
Genes involved in the unfolded protein response (UPR) and ER-associated degradation were induced by GLA production, including; hac1, pdi1, prp1, cnx1, der1, and bap31.
Dietary oils mediate cortisol kinetics and the hepatic mRNA expression profile of stress-responsive genes in gilthead sea bream (Sparus aurata) exposed to crowding stress. Implications on energy homeostasis and stress susceptibility.
Kaushik et al., Castelló de la Plana, Spain. In Comp Biochem Physiol Part D Genomics Proteomics, 2013
The cell-tissue repair response represented by derlin-1, 75 kDa glucose-regulated protein and 170 kDa glucose-regulated protein was triggered at a lower level in 66VO-S than in FO-S fish.
Stress effects caused by the expression of a mutant cellobiohydrolase I and proteasome inhibition in Trichoderma reesei Rut-C30.
Nevalainen et al., Port Macquarie, Australia. In N Biotechnol, 2013
A massive upregulation of UPR- and ERAD-related genes sec61, der1, uba1, bip1, pdi1, prp1, cxl1 and lhs1 was observed by qRT-PCR in the CBHIΔ4-Venus strain with four mutations introduced in the DNA encoding the core domain of CBHI.
Ab initio determination of geometries and vibrational characteristics of building blocks of organic super-conductors: TTF and its derivatives.
Yadav et al., Benares, India. In Spectrochim Acta A Mol Biomol Spectrosc, 2012
Molecular behavior of the building block {[2-(1,3-dithiole-2-ylidene)-1,3-dithiole] ≡ tetrathiafulvalene (TTF)} of organic superconductors have been investigated along with its three derivatives, namely, {[2-(1,3-dioxole-2-ylidene)-1,3-dioxole] ≡ tetraoxafulvalene (TOF)}; [2,2]-bi -[[1,3] oxathiolylidene] ≡ Der I and 2-(3H-Furan-2-ylidene)-[1,3] oxathiole ≡ Der II.
Bax induces activation of the unfolded protein response by inducing HAC1 mRNA splicing in Saccharomyces cerevisiae.
Cakir, New Brunswick, United States. In Yeast, 2012
Bax induced expression of representative UPR target genes such as KAR2, DER1 and GCN4.
Derlin-1-immunopositive inclusions in patients with Alzheimer's disease.
Kawakami et al., Kyoto, Japan. In Neuroreport, 2012
In this study, we found that derlin-1 and PDI were colocalized in neurofibrillary tangles in the brain of patients with Alzheimer's disease.
Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels.
GeneRIF
Shyng et al., Portland, United States. In J Biol Chem, 2012
Derlin-1 expression levels may affect glucose-stimulated insulin secretion by altering surface expression of K(ATP) channels.
Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets.
GeneRIF
Fujimoto et al., Nagoya, Japan. In Mol Biol Cell, 2012
These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively.
Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.
GeneRIF
Kokame et al., Suita, Japan. In Plos One, 2011
Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking.
GeneRIF
Rapoport et al., Boston, United States. In Febs Lett, 2011
Data show that Der1p appears to have a role in a pathway that is parallel to that involving Hrd3p.
Derlin-1 overexpression ameliorates mutant SOD1-induced endoplasmic reticulum stress by reducing mutant SOD1 accumulation.
GeneRIF
Uchino et al., Kumamoto, Japan. In Neurochem Int, 2011
Derlin-1 regulates the turnover of superoxide dismutase 1 by promoting the proteasomal and autophagosomal degradation of SOD1 protein, but not by decreasing mutant SOD1 mRNA levels.
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p.
Impact
Rapoport et al., Boston, United States. In Cell, 2010
This ERAD-L pathway requires a protein complex consisting of the ubiquitin ligase Hrd1p, which spans the ER membrane multiple times, and the membrane proteins Hrd3p, Usa1p, and Der1p.
BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex.
Impact
Shore et al., Montréal, Canada. In Cell, 2008
Of note, BAP31 also associates physically and functionally with the Derlin-1 protein disclocation complex in the DeltaF508 degradation pathway.
Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.
Impact
Johnson et al., College Station, United States. In Cell, 2007
Retrotranslocation was blocked by antibodies against a putative retrotranslocation channel protein, derlin-1, but not Sec61alpha.
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.
Impact
Rapoport et al., Boston, United States. In Cell, 2006
Proteins with misfolded ER-luminal domains use the ERAD-L pathway, in which the Hrd1p/Hrd3p ligase forms a near stoichiometric membrane core complex by binding to Der1p via the linker protein Usa1p.
A membrane protein required for dislocation of misfolded proteins from the ER.
Impact
GeneRIF
Ploegh et al., Boston, United States. In Nature, 2004
Derlin-1 is an important factor for the extraction of certain aberrantly folded proteins from the mammalian ER
Endoplasmic reticulum degradation: reverse protein flow of no return.
Review
Wolf et al., Berlin, Germany. In Faseb J, 1997
Novel ER membrane proteins such as Der1p, Der3p/Hrd1p, or Hrd3p might reprogram the translocon for retrograde transport.
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