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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

DEP domain containing MTOR-interacting protein

DEPTOR
Top mentioned proteins: mTOR, mTORC1, Akt, V1a, mTORC2
Papers on DEPTOR
Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation.
New
Cao et al., Guiyang, China. In Oncol Rep, Feb 2016
In the present study, we found that Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway.
New
Qiu et al., Yancheng, China. In Br J Cancer, Feb 2016
ROC1 knockdown inhibited EMT by inhibiting mammalian target of rapamycin (mTOR) activity via the accumulation of the mTOR-inhibitory protein DEPTOR, a CRL substrate.
Hypoxia increases IGFBP-1 phosphorylation mediated by mTOR inhibition.
New
Gupta et al., London, Canada. In Mol Endocrinol, Jan 2016
Conversely, we activated mTORC1 or mTORC1+mTORC2 by silencing endogenous mTOR inhibitors (TSC2/DEPTOR).
Glucocorticoid receptor ChIP-sequencing of subcutaneous fat reveals modulation of inflammatory pathways.
New
Conzen et al., Chicago, United States. In Obesity (silver Spring), Nov 2015
DEPTOR, an inhibitor of mTOR, was identified as a potential direct GR target gene.
Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.
New
Zhu et al., Beijing, China. In Autophagy, Nov 2015
Here we report that the methyltransferase EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) epigenetically represses several negative regulators of the MTOR (mechanistic target of rapamycin [serine/threonine kinase]) pathway, such as TSC2, RHOA, DEPTOR, FKBP11, RGS16 and GPI.
Regulation of mTORC1 by PI3K signaling.
Review
New
Cantley et al., Boston, United States. In Trends Cell Biol, Sep 2015
Activation of mTORC1 [composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8(mLST8), 40-kDa proline-rich Akt substrate (PRAS40), and DEP domain-containing mTOR-interacting protein (DEPTOR)] depends on the Ras-related GTPases (Rags) and Ras homolog enriched in brain (Rheb) GTPase and requires signals from amino acids, glucose, oxygen, energy (ATP), and growth factors (including cytokines and hormones such as insulin).
Androgen receptor functions as a negative transcriptional regulator of DEPTOR, mTOR inhibitor.
Inouye et al., In J Toxicol Sci, 2014
To clarify this mechanism, we focused on DEPTOR, a naturally occurring inhibitor of mTOR.
Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells.
Waitzberg et al., São Paulo, Brazil. In Biomed Res Int, 2014
Inhibition of the mTORC1 pathway markers, p70S6 K1, SREBP1, and LIPIN1, as well as an increase in DEPTOR expression (the main inhibitor of the mTOR) was detected in HB4aC5.2.
High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
Wu et al., Guangzhou, China. In Onco Targets Ther, 2014
OBJECTIVE: The disheveled, Egl-10, and pleckstrin (DEP) domain containing mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR) is a binding protein containing mTOR complex 1 (mTORC1), mTOR complex 2 (mTORC2), and an endogenous mTOR inhibitor.
Targeting mTOR: evaluating the therapeutic potential of resveratrol for cancer treatment.
Review
Liu et al., Taiwan. In Anticancer Agents Med Chem, 2013
It has been found that resveratrol targets multiple components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural compound and its derivatives may offer a promising new cancer treatment.
Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase.
Review
Li et al., Ann Arbor, United States. In Protein Cell, 2013
When acting alone, SAG scavenges oxygen radicals by forming inter- and intra-molecular disulfide bonds, whereas by forming a complex with other components of the SCF E3 ligase, SAG promotes ubiquitination and degradation of a number of protein substrates, including c-JUN, DEPTOR, HIF-1α, IκBα, NF1, NOXA, p27, and procaspase-3, thus regulating various signaling pathways and biological processes.
The multi-functional roles of GNMT in toxicology and cancer.
Review
Chen et al., Taipei, Taiwan. In Toxicol Appl Pharmacol, 2013
In terms of the mechanism, besides dysregulation of epigenetic modification, insights have been provided by recent identification of two novel proteins interacting with GNMT-DEPTOR and NPC2.
DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.
Impact
Sabatini et al., Cambridge, United States. In Cell Metab, 2012
DEP domain-containing mTOR-interacting protein (DEPTOR) inhibits the mechanistic target of rapamycin (mTOR), but its in vivo functions are unknown.
DEPTOR ubiquitination and destruction by SCF(β-TrCP).
Review
GeneRIF
Wei et al., Boston, United States. In Am J Physiol Endocrinol Metab, 2012
this review discusses beta-TrCP's new downstream substrate, DEPTOR, as well as summarize the novel functional aspects of beta-TrCP in controlling cell growth and regulating autophagy, in part through governing the stability of DEPTOR.[Review]
An evolving role for DEPTOR in tumor development and progression.
Review
Wei et al., Boston, United States. In Neoplasia, 2012
Recently, DEPTOR was identified as an endogenous mTOR inhibitor that could suppress mTOR activity in vivo.
Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma.
GeneRIF
Chen et al., Taipei, Taiwan. In Mol Med, 2011
GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
GeneRIF
Wei et al., Boston, United States. In Mol Cell, 2011
misregulation of the DEPTOR destruction pathway might contribute to aberrant activation of mTOR in disease.
DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.
GeneRIF
Sun et al., Ann Arbor, United States. In Mol Cell, 2011
DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy
mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
GeneRIF
Pagano et al., New York City, United States. In Mol Cell, 2011
mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR.
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Impact
GeneRIF
Sabatini et al., Cambridge, United States. In Cell, 2009
DEPTOR is highly overexpressed in a subset of multiple myelomas harboring cyclin D1/D3 or c-MAF/MAFB translocations.
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