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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Deoxyguanosine kinase

deoxyguanosine kinase
Top mentioned proteins: deoxycytidine kinase, TK2, HAD, CAN, ACID
Papers on deoxyguanosine kinase
Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome.
Dimmock et al., Milwaukee, United States. In Free Radic Biol Med, Feb 2016
UNASSIGNED: A novel rat model for a well-characterized human mitochondrial disease, mitochondrial DNA depletion syndrome with associated deoxyguanosine kinase (DGUOK) deficiency, is described.
The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.
Rampazzo et al., Padova, Italy. In J Biol Chem, Nov 2015
The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase.
Nucleoside Analog Activity in Malignant Melanoma Cell Lines.
Lotfi et al., Linköping, Sweden. In Nucleosides Nucleotides Nucleic Acids, 2014
Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies.
Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs.
Wang et al., Uppsala, Sweden. In Antimicrob Agents Chemother, 2014
Mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) catalyze the initial phosphorylation of deoxynucleosides in the synthesis of the DNA precursors required for mitochondrial DNA (mtDNA) replication and are essential for mitochondrial function.
Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs.
Wang et al., Uppsala, Sweden. In Biochem Biophys Res Commun, 2014
Mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) catalyze the initial rate limiting phosphorylation of deoxynucleosides and are essential enzymes for mitochondrial function.
Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro.
Ueda et al., Fukui, Japan. In Anticancer Res, 2014
BACKGROUND/AIM: Clofarabine is transported into leukemic cells via the equilibrative nucleoside transporters (hENT) 1 and 2 and the concentrative nucleoside transporter (hCNT) 3, then phosphorylated by deoxycytidine kinase (dCK) and deoxyguanosine kinase (dGK) to an active triphosphate metabolite.
Long-term outcomes after liver transplantation for deoxyguanosine kinase deficiency: a single-center experience and a review of the literature.
Santer et al., Hamburg, Germany. In Liver Transpl, 2014
Deoxyguanosine kinase (DGUOK) deficiency is a well-known cause of hepatocerebral mitochondrial DNA depletion syndromes, which include a broad spectrum of clinical presentations.
Mitochondrial thymidine kinase 2 but not deoxyguanosine kinase is up-regulated during the stationary growth phase of cultured cells.
Wang et al., Uppsala, Sweden. In Nucleosides Nucleotides Nucleic Acids, 2013
Mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) catalyze the initial phosphorylation of pyrimidine and purine deoxyribonucleosides, and are essential for maintaining mitochondrial dNTP pools for mitochondrial DNA replication.
Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line.
Ueda et al., Fukui, Japan. In Bmc Cancer, 2013
BACKGROUND: Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellular active metabolite ara-G triphosphate (ara-GTP) by both cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase.
Is the expression of deoxynucleoside kinases and 5'-nucleotidases in animal tissues related to the biological effects of nucleoside analogs?
Eriksson, Uppsala, Sweden. In Curr Med Chem, 2012
In this chapter the expression patterns of the four dNKs i.e.cytosolic deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1) and the mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) as well as the six intracellular 5'-NTs: cN-IA, cN-IB, cN-II, cN-III, cdN, mdN, present in animal cells and tissues will be described.
Mechanism of action of pentostatin and cladribine in hairy cell leukemia.
Johnston, Winnipeg, Canada. In Leuk Lymphoma, 2011
CdA has several unique mechanisms of action over dAdo and these include the incorportation of CdATP into DNA, the inhibition of DNA polymerase β, and the phosphorylation of CdA to CdATP by deoxyguanosine kinase in mitochondria.
Neurological disorders of purine and pyrimidine metabolism.
Pompucci et al., Siena, Italy. In Curr Top Med Chem, 2010
deficiency of the purine salvage enzymes hypoxanthine-guanine phosphoribosyltransferase and deoxyguanosine kinase are associated to the most severe pathologies, the former due to an unexplained adverse effect exerted on the development and/or differentiation of dopaminergic neurons, the latter due to impairment of mitochondrial functions.
[Mitochondrial disease and mitochondrial DNA depletion syndromes].
Hsu et al., Taiwan. In Acta Neurol Taiwan, 2009
These involved genes are divided into two groups including 1) DNA polymerase gamma (POLG, POLG2) and Twinkle genes whose products function directly at the mtDNA replication fork, and 2) adenine nucleotide translocator 1, thymidine phosphorylase, thymidine kinase 2, deoxyguanosine kinase, ADP-forming succinyl-CoA synthetase ligase, MPV17 whose products supply the mitochondria with deoxyribonucleotide triphosphate pools needed for mtDNA replication, and possible mutation in the RRM2B gene.
Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.
Elpeleg et al., Jerusalem, Israel. In Nat Genet, 2001
Two of the four human deoxyribonucleoside kinases, deoxyguanosine kinase (dGK) and thymidine kinase-2 (TK2), are expressed in mitochondria.
The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA.
Cohen et al., Haifa, Israel. In Nat Genet, 2001
This interval encompasses the gene (DGUOK) encoding the mitochondrial deoxyguanosine kinase (dGK).
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