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Deoxycytidine kinase

deoxycytidine kinase, dCK
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Cytidine Deaminase, POLYMERASE, ACID
Papers on deoxycytidine kinase
Deoxycytidine kinase is downregulated under hypoxic conditions and confers resistance against cytarabine in acute myeloid leukaemia.
New
Wellbrock et al., Hamburg, Germany. In Eur J Haematol, Dec 2015
Interestingly upon cultivation under hypoxia, the expression of the cytarabine-activating enzyme deoxycytidine kinase was downregulated in all analyzed AML cell lines and primary AML samples representing a possible mechanism for resistance to chemotherapy.
A crucial role for ATR in the regulation of deoxycytidine kinase activity.
New
Bontemps et al., Brussels, Belgium. In Biochem Pharmacol, Dec 2015
UNASSIGNED: Deoxycytidine kinase (dCK) (EC 2.7.1.74) is a key enzyme for salvage of deoxynucleosides and activation of numerous anticancer and antiviral nucleoside analogs.
Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases.
New
Greenberg et al., Baltimore, United States. In J Org Chem, Dec 2015
Because the nucleoside analogue is a poor phosphorylation substrate for human deoxycytidine kinase, a pro-nucleotide form of the 4-bromopyridone was used to incorporate this analogue into cellular DNA.
Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer.
New
Lee et al., South Korea. In Oncology, Nov 2015
Potential biomarkers for gemcitabine response include the activities of cytidine deaminase (CDA), human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (DCK), and ribonucleotide reductase M1 (RRM1).
The clinical implication of single nucleotide polymorphisms in deoxycytidine kinase in chronic hepatitis B patients treated with lamivudine.
New
Han et al., Seoul, South Korea. In J Med Virol, Oct 2015
UNASSIGNED: Deoxycytidine kinase (dCK) is a critical enzyme involved in intracellular phosphorylation of lamivudine (LAM) to its active triphosphates.
Acquired resistance to decitabine and cross-resistance to gemcitabine during the long-term treatment of human HCT116 colorectal cancer cells with decitabine.
New
Iwakawa et al., Kōbe, Japan. In Oncol Lett, Aug 2015
Furthermore, the protein expression levels of cytidine deaminase (CDA) were increased, while those of deoxycytidine kinase (dCK) were decreased in DAC-resistant HCT116 cells; by contrast, the mRNA expression levels for these proteins were not significantly altered.
Coumarins as Potential Inhibitors of DNA Polymerases and Reverse Transcriptases. Searching New Antiretroviral and Antitumoral Drugs.
Review
Pungitore et al., San Luis, Argentina. In Curr Drug Discov Technol, 2014
Coumarins and derivates exhibit potent inhibitory effects on HIV-1 replication in lymphocytes and compounds isolated from Calophyllum inophyllum or DCK derivates showed inhibitory activity against human RT.
Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase.
Negroni et al., Strasbourg, France. In Plos One, 2014
Using an original procedure whereby mutant genes are generated based on the use of conditional lentivector genome mobilisation, we recently described, for the first time, the identification of a human deoxycytidine kinase (dCK) mutant (G12) that sensitises a panel of cancer cell lines to treatment with the dCK analogue gemcitabine.
The role of clofarabine in acute myeloid leukemia.
Review
Jabbour et al., Houston, United States. In Leuk Lymphoma, 2013
Compared to its precursors, clofarabine has an increased resistance to deamination and phosphorolysis, and hence better stability as well as higher affinity to deoxycytidine kinase (dCyd), the rate-limiting step in nucleoside phosphorylation.
Gemcitabine versus Modified Gemcitabine: a review of several promising chemical modifications.
Review
Benoit et al., Angers, France. In Mol Pharm, 2013
They can provide (i) a protection against deamination, (ii) a better storage and (iii) a prolonged release in the cell, (iv) a possible use in the case of deoxycytidine kinase deficiency, and (v) transporter deficiency.
New insights into the synergism of nucleoside analogs with radiotherapy.
Review
Xu et al., Orlando, United States. In Radiat Oncol, 2012
Recent advances in our understanding of the structure and function of deoxycytidine kinase (dCK), a critical enzyme required for the anti-tumor activity for many nucleoside analogs, have clarified the mechanistic role this kinase plays in chemo- and radio-sensitization.
Is the expression of deoxynucleoside kinases and 5'-nucleotidases in animal tissues related to the biological effects of nucleoside analogs?
Review
Eriksson, Uppsala, Sweden. In Curr Med Chem, 2012
In this chapter the expression patterns of the four dNKs i.e.cytosolic deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1) and the mitochondrial thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) as well as the six intracellular 5'-NTs: cN-IA, cN-IB, cN-II, cN-III, cdN, mdN, present in animal cells and tissues will be described.
Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma.
GeneRIF
Van Laethem et al., Brussels, Belgium. In Gastroenterology, 2012
High levels of dCK in pancreatic ductal adenocarcinoma predict longer survival times in patients treated with adjuvant gemcitabine.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
GeneRIF
Horii et al., Sendai, Japan. In Biochem Biophys Res Commun, 2012
These results indicate that the inactivation of DCK is one of the crucial mechanisms in acquisition of gemcitabine resistance.
A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival.
GeneRIF
Rutschmann et al., London, United Kingdom. In J Immunol, 2012
Deoxycytidine kinase is a new regulator of hematopoietic integrity and lymphocyte quiescence and survival.
p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.
GeneRIF
Besson et al., Toulouse, France. In J Clin Invest, 2012
p27 has a role in cytokinesis via the regulation of citron-K activity
Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis.
GeneRIF
D'Avino et al., Cambridge, United Kingdom. In J Cell Biol, 2011
The Sti/CIT-K maintains correct RhoA localization at the cleavage site, which is necessary for proper RhoA activity and contractile ring dynamics.
Enzyme-catalyzed activation of anticancer prodrugs.
Review
Impact
Vermeulen et al., Amsterdam, Netherlands. In Pharmacol Rev, 2004
The following endogenous enzymes are discussed: aldehyde oxidase, amino acid oxidase, cytochrome P450 reductase, DT-diaphorase, cytochrome P450, tyrosinase, thymidylate synthase, thymidine phosphorylase, glutathione S-transferase, deoxycytidine kinase, carboxylesterase, alkaline phosphatase, beta-glucuronidase and cysteine conjugate beta-lyase.
Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo.
Impact
Fine et al., Boston, United States. In Nat Med, 1996
The rate-limiting step in intracellular ara-C activation is phosphorylation of the prodrug by deoxycytidine kinase (dCK).
2-Chlorodeoxyadenosine dose escalation in nonhematologic malignancies.
Impact
Piro et al., Los Angeles, United States. In J Clin Oncol, 1993
In tumor tissue samples, deoxycytidine kinase (dCK) levels were measured by both enzyme activity and immunoreactive protein analysis.
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