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Methyl-CpG binding domain protein 2

demethylase, MBD2
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Histone, CAN, V1a, ACID, HAD
Papers using demethylase antibodies
ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data
Supplier
Brunet Anne et al., In Nature, 2004
... longevity by deficiencies in ASH-2 complex members is dependent on the presence of the H3K4me3 demethylase RBR-2 and of an intact germlinea–b, Lifespan of genetically wildtype F3 ...
Papers on demethylase
let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex.
New
Yang et al., Taipei, Taiwan. In Cell Rep, Feb 2016
The nuclear ARID3B complex recruits histone demethylase 4C to reduce histone 3 lysine 9 trimethylation and promotes the transcription of stemness factors.
Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.
New
Impact
So et al., Los Angeles, United States. In Cancer Cell, Feb 2016
PRMT1 is necessary but not sufficient for leukemic transformation, which requires co-recruitment of KDM4C, an H3K9 demethylase, by chimeric transcription factors to mediate epigenetic reprogramming.
Lycopene protects against atrazine-induced hepatotoxicity through modifications of cytochrome P450 enzyme system in microsomes.
New
Zhang et al., Harbin, China. In Exp Toxicol Pathol, Feb 2016
These results showed that ATR induced the increase of total CYP450 and Cytochrome b5 (Cyt b5) contents and stimulated the activities of CYP450s enzymes (erythromycin N-demethylase (ERND), aminopyrin N-demethylase (APND), aniline-4-hydeoxylase (AH) and NADPH-cytochrome c reductase (NCR)) in hepatic microsomes.
Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors.
New
Xiong et al., Shanghai, China. In Bioorg Med Chem Lett, Feb 2016
In 2012, Kruidenier et al. reported GSK-J1 as a selective Jumonji H3K27 demethylase (JMJD3 and UTX) inhibitor.
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.
New
Ding et al., Chongqing, China. In Cell Rep, Feb 2016
UNASSIGNED: The histone lysine demethylase KDM4C is often overexpressed in cancers primarily through gene amplification.
N6-methyl-adenosine modification in mRNA: Machinery, Function and Implications in health and diseases.
Review
New
Das et al., Calcutta, India. In Febs J, Jan 2016
Methylation is reversible which is accomplished by the orchestrated action of highly conserved methyl-transferase (m(6) A writer) and demethylase (m(6) A eraser) enzymes to shape the cellular "epitranscriptome".
Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.
New
Impact
Zhang et al., Los Angeles, United States. In Cell Stem Cell, Jan 2016
We previously showed in mice that reduction of histone H3 lysine 9 trimethylation (H3K9me3) through ectopic expression of the H3K9me3 demethylase Kdm4d greatly improves SCNT embryo development.
Biochemistry and regulation of the protein arginine methyltransferases (PRMTs).
Review
New
Hevel et al., Logan, United States. In Arch Biochem Biophys, Jan 2016
Precise control of PRMT activity is a critical component to eukaryotic cell health, especially given that an arginine demethylase has not been identified.
HIV-Induced Epigenetic Alterations in Host Cells.
Review
New
Shata et al., Cincinnati, United States. In Adv Exp Med Biol, Dec 2015
These epigenetic drugs include histone deacetylase inhibitors (HDACI), histone methyltransferase inhibitors (HMTI), histone demethylase inhibitors, and DNA methyltransferase inhibitors (DNMTI).
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally.
New
Impact
Kimmins et al., Montréal, Canada. In Science, Dec 2015
We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase KDM1A (also known as LSD1) during spermatogenesis reduced H3K4 dimethylation in sperm.
Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activity.
Review
New
Simeonov et al., Rockville, United States. In Drug Discov Today Technol, Nov 2015
Histone methylation is a prevalent and dynamic chromatin modification, executed by the action of histone methyltransferases (HMTs) and demethylases (HDMs).
T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.
New
Impact
Su et al., Chapel Hill, United States. In Immunity, Nov 2015
We show that UTX, a histone H3 lysine 27 (H3K27) demethylase, supports T follicular helper (Tfh) cell responses that are essential for B cell antibody generation and the resolution of chronic viral infections.
Epigenetic control of the immune system: a lesson from Kabuki syndrome.
Review
New
Rigante et al., Florence, Italy. In Immunol Res, Oct 2015
Its cause is related to mutations of two genes: KMT2D (histone-lysine N-methyltransferase 2D) and KDM6A (lysine-specific demethylase 6A), both functioning as epigenetic modulators through histone modifications in the course of embryogenesis and in several biological processes.
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.
New
Impact
Lu et al., Houston, United States. In Nat Cell Biol, Sep 2015
Locally generated fumarate inhibits KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 Lys 36; in turn, this increases the accumulation of the Ku70-containing DNA-PK at DSB regions for non-homologous end-joining DNA repair and cell survival.
Downregulation of miR-221 Inhibits Cell Migration and Invasion through Targeting Methyl-CpG Binding Domain Protein 2 in Human Oral Squamous Cell Carcinoma Cells.
Chen et al., Guangzhou, China. In Biomed Res Int, 2014
Furthermore, methyl-CpG binding domain protein 2 (MBD2) was identified as a direct target gene of miR-221.
A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility.
GeneRIF
Damaraju et al., Edmonton, Canada. In Eur J Hum Genet, 2012
A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility.
Preferential binding of the methyl-CpG binding domain protein 2 at methylated transcriptional start site regions.
GeneRIF
Dante et al., Lyon, France. In Epigenetics, 2011
The association between MBD2 binding and transcriptional repression weakened as the distance between binding site and TSS increased, suggesting that MBD2 represses transcriptional initiation
Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.
GeneRIF
Van Meir et al., Atlanta, United States. In Cancer Res, 2011
MBD2 overexpression during gliomagenesis may drive tumor growth by suppressing the antiangiogenic activity of a key tumor BAI1.
Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.
GeneRIF
Ginder et al., Richmond, United States. In Mol Cancer Res, 2011
These results show a role for MBD2 in cancer progression and provide support for the prospect of targeting MBD2 therapeutically in aggressive breast cancers.
Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury.
GeneRIF
Wang et al., Wuhan, China. In Circulation, 2011
Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury.
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