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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Delta-like 4

delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, AGE, p300
Papers on delta4
Self-Renewal and High Proliferative Colony Forming Capacity of Late-Outgrowth Endothelial Progenitors is Regulated by Cyclin-Dependent Kinase Inhibitors Driven by Notch Signaling.
New
Khosrotehrani et al., Australia. In Stem Cells, 06 Feb 2016
Transcriptomic analysis identified cyclin-dependent kinase (CDK) cell cycle inhibiting genes (p16, p21, and p57), the Notch signaling pathway (dll1, dll4, hes1, and hey1), and the endothelial cytokine il33 as highly expressed in CD34 + ECFC.
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
New
Stanley et al., New York City, United States. In J Immunol, 01 Feb 2016
In this study, we show that Lfng/Mfng/Rfng triple knockout (Fng tKO) mice exhibited reduced binding of DLL4 Notch ligand to CD4/CD8 double-negative (DN) T cell progenitors, and reduced expression of NOTCH1 targets Deltex1 and CD25.
MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth.
New
Wu et al., Nanjing, China. In Cancer Lett, 29 Jan 2016
UNASSIGNED: Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues.
The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation.
New
Zhang et al., Shanghai, China. In J Immunol, 28 Jan 2016
We have recently demonstrated that dendritic cells (DCs) expressing the Notch ligand DLL4 are critical for eliciting alloreactive T cell responses and induction of graft-versus-host disease in mice.
Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells.
New
Subramaniam et al., Kansas City, United States. In Oncotarget, 11 Jan 2016
Furthermore, levels of Notch 1-4 receptors, their ligands Jagged1, Jagged2, DLL1, DLL3, DLL4 and the downstream target protein Hes-1 were reduced.
Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation.
New
Yan et al., San Francisco, United States. In Clin Cancer Res, 20 Dec 2015
PURPOSE: Although agents targeting Delta-like ligand 4 (DLL4) have shown great promise for angiogenesis-based cancer therapy, findings in recent studies have raised serious safety concerns.
DLL4 as a predictor of pelvic lymph node metastasis and a novel prognostic biomarker in patients with early-stage cervical cancer.
New
Xiao et al., Harbin, China. In Tumour Biol, 06 Dec 2015
UNASSIGNED: Delta-like ligand 4 (DLL4), one of the five Notch signaling ligands in mammals, has an important function in proliferation, invasion, metastasis, progression, and angiogenesis of malignancies.
The Vascular Notch Ligands Delta-Like Ligand 4 (DLL4) and Jagged1 (JAG1) Have Opposing Correlations with Microvascularization but a Uniform Prognostic Effect in Primary Glioblastoma: A Preliminary Study.
New
Wang et al., Fuzhou, China. In World Neurosurg, 04 Dec 2015
PURPOSE: Delta-like ligand 4 (DLL4) and Jagged1 (JAG1), 2 vascular Notch ligands, are involved in the process of tumor angiogenesis.
Effect of Soyabean Isoflavones Exposure on Onset of Puberty, Serum Hormone Concentration and Gene Expression in Hypothalamus, Pituitary Gland and Ovary of Female Bama Miniature Pigs.
New
Yin et al., Changsha, China. In Asian-australas J Anim Sci, Nov 2015
The expression of KiSS-1 metastasis-suppressor (KISS1), steroidogenic acute regulatory protein (StAR) and 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase (3β-HSD) was reduced (p<0.01) in SIF-supplemented groups.
Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
New
Impact
Garcia et al., Stanford, United States. In Science, Mar 2015
The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.
New
Impact
Fowlkes et al., Bethesda, United States. In Immunity, Feb 2015
We have found that Delta Like Ligand 4 (DLL4)-induced Notch signaling potentiates phosphatidylinositol 3-OH kinase (PI3K)-dependent signaling downstream of the T cell receptor+CD28, allowing naive CD4(+) T cells to respond to lower doses of antigen.
Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen.
New
Impact
Butte et al., Stanford, United States. In Immunity, Feb 2015
In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.
Petrova et al., In J Clin Invest, 2014
We further demonstrated that this continuous regeneration process is mediated by Notch signaling and that the expression of the Notch ligand delta-like 4 (DLL4) in lacteals requires activation of VEGFR3 and VEGFR2.
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
Impact
Buffa et al., Oxford, United Kingdom. In Cancer Cell, 2013
This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling.
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
GeneRIF
Aikawa et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
GeneRIF
Skokos et al., United States. In J Exp Med, 2012
Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration.
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.
Impact
Boehm et al., Germany. In Cell, 2012
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
GeneRIF
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
GeneRIF
Parreira et al., Lisbon, Portugal. In Plos One, 2011
This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis.
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
GeneRIF
Sergeeva et al., Moscow, Russia. In Plos One, 2011
Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia.
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