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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Nov 2015.

Delta-like 4

delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, AGE, p300
Papers on delta4
DLL4 as a predictor of pelvic lymph node metastasis and a novel prognostic biomarker in patients with early-stage cervical cancer.
Xiao et al., Harbin, China. In Tumour Biol, 06 Dec 2015
UNASSIGNED: Delta-like ligand 4 (DLL4), one of the five Notch signaling ligands in mammals, has an important function in proliferation, invasion, metastasis, progression, and angiogenesis of malignancies.
The vascular Notch ligands delta-like ligand 4 (DLL4) and Jagged1 (JAG1) have opposing correlations with microvascularization but uniform prognostic effect in primary glioblastoma: a preliminary study.
Wang et al., Fuzhou, China. In World Neurosurg, 04 Dec 2015
PURPOSE: Delta-like ligand 4 (DLL4) and Jagged1 (JAG1), two vascular Notch ligands, are involved in the process of tumor angiogenesis.
Pro‑angiogenic microRNA‑296 upregulates vascular endothelial growth factor and downregulates Notch1 following cerebral ischemic injury.
Liu et al., Changsha, China. In Mol Med Report, 13 Nov 2015
Adenovirus‑mediated overexpression of miR‑296 markedly enhanced the formation of capillary‑like structures in human umbilical vein endothelial cells, parallel with significantly increased expression levels of vascular endothelial growth factor (VEGF) and VEGF receptor 2, and reduced expression levels of DLL4 and Notch1.
Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Garcia et al., Stanford, United States. In Science, Mar 2015
The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen.
Butte et al., Stanford, United States. In Immunity, Feb 2015
In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.
Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.
Fowlkes et al., Bethesda, United States. In Immunity, Feb 2015
We have found that Delta Like Ligand 4 (DLL4)-induced Notch signaling potentiates phosphatidylinositol 3-OH kinase (PI3K)-dependent signaling downstream of the T cell receptor+CD28, allowing naive CD4(+) T cells to respond to lower doses of antigen.
Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity.
Vidal-Puig et al., Córdoba, Spain. In Biochim Biophys Acta, Jan 2015
Here, we describe its function and dysregulation by factors such as oxidative stress, hypoxia and inflammation and provide evidence indicating that dihydroceramides constitute a biologically active molecule from the sphingolipid family with certain differential characteristics with respect to its delta-4 unsaturated counterparts, the ceramides.
Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation.
Takacs et al., Rio de Janeiro, Brazil. In Immun Ageing, Dec 2014
RESULTS: As an initial approach, here we report that the decline of human thymic FOXN1 transcription correlates with age, while other genes, DLL1, DLL4 and WNT4, essential for thymopoiesis, are constitutively transcribed.
VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning.
Jakobsson et al., Stockholm, Sweden. In Biochem Soc Trans, Dec 2014
Delta-like 4 (DLL4), on the other hand, is provided as an endothelial membrane bound ligand.
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.
Petrova et al., In J Clin Invest, Dec 2014
We further demonstrated that this continuous regeneration process is mediated by Notch signaling and that the expression of the Notch ligand delta-like 4 (DLL4) in lacteals requires activation of VEGFR3 and VEGFR2.
Role of Notch signaling pathway in gastric cancer: a meta-analysis of the literature.
Zhou et al., Chengdu, China. In World J Gastroenterol, Aug 2014
Overall, the expression of Notch1, Notch2, Delta-like 4 and Hes1 was significantly higher in tumor tissues of GC compared to normal tissues.
Mechanisms regulating GABAergic neuron development.
Partanen et al., Heidelberg, Germany. In Cell Mol Life Sci, Apr 2014
By comparing the molecular regulation of these events across CNS, we broadly identify three regions utilizing distinct molecular toolkits for GABAergic fate determination: telencephalon-anterior diencephalon (DLX2 type), posterior diencephalon-midbrain (GATA2 type) and hindbrain-spinal cord (PTF1A and TAL1 types).
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
Buffa et al., Oxford, United Kingdom. In Cancer Cell, 2013
This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling.
The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?
Helewski et al., Katowice, Poland. In Contemp Oncol (pozn), 2012
One of the most prominent factors considered as a promising target in such therapy is the Notch ligand Delta-like 4 (DLL4).
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Aikawa et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
Skokos et al., United States. In J Exp Med, 2012
Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration.
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.
Boehm et al., Germany. In Cell, 2012
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
Parreira et al., Lisbon, Portugal. In Plos One, 2011
This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis.
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
Sergeeva et al., Moscow, Russia. In Plos One, 2011
Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia.
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