Mechanisms regulating GABAergic neuron development.
Heidelberg, Germany. In Cell Mol Life Sci, 07 Dec 2013
By comparing the molecular regulation of these events across CNS, we broadly identify three regions utilizing distinct molecular toolkits for GABAergic fate determination: telencephalon-anterior diencephalon (DLX2 type), posterior diencephalon-midbrain (GATA2 type) and hindbrain-spinal cord (PTF1A and TAL1 types).
Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
Pittsburgh, United States. In Oncotarget, 19 Oct 2013
Torin-1 also affected the expression of markers for cell proliferation, angio-/lympho-genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44.
Delta-like ligand 4-notch blockade and tumor radiation response.
Oxford, United Kingdom. In J Natl Cancer Inst, 2012
In DLL4-expressing CR carcinoma xngrft model, Notch blockade combined with ionizing radiation caused tumor growth delay. The DLL4 monoclnl antibody in combination with ionizing radiation also delayed tumor growth in the non-DLL4-expressing xngrft model
Gonadal transactivation of STARD1, CYP11A1 and HSD3B.
Lubbock, United States. In Front Biosci, 2011
The steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme and specific 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerases initiate the essential process of steroidogenesis in the gonads.
Control of endothelial sprouting by a Tel-CtBP complex.
Leiden, Netherlands. In Nat Cell Biol, 2010
The Tel-CtBP complex temporally restricts a VEGF (vascular endothelial growth factor)-mediated pulse of dll4 expression and thereby directly links VEGF receptor intracellular signalling and intercellular Notch-Dll4 signalling.