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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Delta-like 4

delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, AGE, fibrillin-1
Papers on delta4
DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice.
New
Indraccolo et al., Padova, Italy. In Carcinogenesis, 29 Nov 2014
In this study, we aimed to investigate the role of DLL4 in the regulation of NOTCH signaling in T-ALL cells in the context of different types of NOTCH1 mutation or wild type NOTCH receptor, as well as the effects of DLL4 neutralization on T-ALL engraftment in mice.
Expression and Significance of DLL4--Notch Signaling Pathway in the Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells into Cardiomyocytes Induced by 5-Azacytidine.
New
Chen et al., Taizhou, China. In Cell Biochem Biophys, 25 Nov 2014
RT-PCR showed that a stable higher level expression of DLL4 and Notch1 gene in 5-aza-induced group was observed compared to that in the control group.
Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors.
New
Miao et al., Shanghai, China. In Cardiovasc Res, 23 Nov 2014
Overexpression of NAMPT led to a SIRT1-depedent enhancement of Notch-1 intracellular domain deacetylation, which inhibited Delta-like ligand-4 (DLL4)-Notch signalling and thereby up-regulated of VEGFR-2 and VEGFR-3.
A Phase 1 Dose Escalation and Expansion Study of the Anti-Cancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors.
New
Sikic et al., Stanford, United States. In Clin Cancer Res, 16 Nov 2014
UNLABELLED: Purpose: This Phase I trial evaluated the safety, pharmacokinetics, pharmacodynamics and of demcizumab (OMP-21M18), a humanized IgG2 monoclonal antibody targeting the Notch ligand DLL4 in adult patients with advanced malignancies.
Dihydroceramide Desaturase 1, the gatekeeper of ceramide induced Lipotoxicity.
Review
New
Vidal-Puig et al., Córdoba, Spain. In Biochim Biophys Acta, 02 Nov 2014
Here, we describe its function, its dysregulation by factors such as oxidative stress, hypoxia and inflammation and provide evidence indicating that dihydroceramides constitute a biologically active molecule from the sphingolipid family with certain differential characteristics with respect to its delta-4 unsaturated counterparts the ceramides.
[Over-Expression of DLL4/Notch1 Ligand Inhibits Proliferation of K562 Cells].
New
Ma et al., Fuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 30 Sep 2014
This study was aimed to explore the effect of DLL4/Notch1 ligand on cell growth in leukemia cell line K562 and its relevant mechanism.
Mechanisms regulating GABAergic neuron development.
Review
New
Partanen et al., Heidelberg, Germany. In Cell Mol Life Sci, Apr 2014
By comparing the molecular regulation of these events across CNS, we broadly identify three regions utilizing distinct molecular toolkits for GABAergic fate determination: telencephalon-anterior diencephalon (DLX2 type), posterior diencephalon-midbrain (GATA2 type) and hindbrain-spinal cord (PTF1A and TAL1 types).
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
New
Impact
Buffa et al., Oxford, United Kingdom. In Cancer Cell, Sep 2013
This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling.
Robustness in angiogenesis: notch and BMP shaping waves.
Review
New
Zwijsen et al., Leuven, Belgium. In Trends Genet, Mar 2013
In particular, we focus on how Delta-like ligand 4 (DLL4)-Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip-stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs.
The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?
Review
Helewski et al., Katowice, Poland. In Contemp Oncol (pozn), 2012
One of the most prominent factors considered as a promising target in such therapy is the Notch ligand Delta-like 4 (DLL4).
The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy.
Review
O'Byrne et al., Dublin, Ireland. In J Thorac Oncol, 2012
However Smoothened inhibitors, gamma-secretase inhibitors, anti-DLL4 antagonists, Wnt antagonists, and CBP/β-catenin inhibitors have all shown promising anticancer effects in early studies.
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
GeneRIF
Aikawa et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
GeneRIF
Skokos et al., United States. In J Exp Med, 2012
Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration.
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Impact
Adams et al., Münster, Germany. In Nature, 2012
Signalling triggered by VEGF-A (also known as VEGF) has been shown to induce expression of the Notch ligand DLL4 in angiogenic vessels and, most prominently, in the tip of endothelial sprouts.
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.
Impact
Boehm et al., Germany. In Cell, 2012
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
GeneRIF
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
GeneRIF
Parreira et al., Lisbon, Portugal. In Plos One, 2011
This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis.
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
GeneRIF
Sergeeva et al., Moscow, Russia. In Plos One, 2011
Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Impact
Potente et al., Frankfurt am Main, Germany. In Nature, 2011
Consequently, endothelial cells lacking SIRT1 activity are sensitized to Notch signalling, resulting in impaired growth, sprout elongation and enhanced Notch target gene expression in response to DLL4 stimulation, thereby promoting a non-sprouting, stalk-cell-like phenotype.
Control of endothelial sprouting by a Tel-CtBP complex.
Impact
Baker et al., Leiden, Netherlands. In Nat Cell Biol, 2010
The Tel-CtBP complex temporally restricts a VEGF (vascular endothelial growth factor)-mediated pulse of dll4 expression and thereby directly links VEGF receptor intracellular signalling and intercellular Notch-Dll4 signalling.
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