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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Dec 2014.

Delta-like 4

delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, AGE, fibrillin-1
Papers on delta4
VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning.
New
Jakobsson et al., Stockholm, Sweden. In Biochem Soc Trans, 01 Jan 2015
Delta-like 4 (DLL4), on the other hand, is provided as an endothelial membrane bound ligand.
Early Dental Epithelial Transcription Factors Distinguish Ameloblastoma from Keratocystic Odontogenic Tumor.
New
Morgan et al., Kuopio, Finland. In J Dent Res, 14 Dec 2014
Early dental epithelial markers PITX2, MSX2, DLX2, RUNX1, and ISL1 were differentially overexpressed in ameloblastoma, indicating its dental identity.
DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer.
New
Costa et al., Rio de Janeiro, Brazil. In Arch Oral Biol, 22 Nov 2014
We also investigated the association between polymorphisms in the genes AXIN2, BMP2, BMP4, BMP7, DLX1, DLX2, and MMP3 and oral cleft with and without history of cancer.
Dihydroceramide Desaturase 1, the gatekeeper of ceramide induced Lipotoxicity.
Review
New
Vidal-Puig et al., Córdoba, Spain. In Biochim Biophys Acta, 02 Nov 2014
Here, we describe its function, its dysregulation by factors such as oxidative stress, hypoxia and inflammation and provide evidence indicating that dihydroceramides constitute a biologically active molecule from the sphingolipid family with certain differential characteristics with respect to its delta-4 unsaturated counterparts the ceramides.
Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.
New
Kamath et al., In Mabs, Sep 2014
UNLABELLED: Delta-like-4 ligand (DLL4) plays an important role in vascular development and is widely expressed on the vasculature of normal and tumor tissues.
Mechanisms regulating GABAergic neuron development.
Review
New
Partanen et al., Heidelberg, Germany. In Cell Mol Life Sci, Apr 2014
By comparing the molecular regulation of these events across CNS, we broadly identify three regions utilizing distinct molecular toolkits for GABAergic fate determination: telencephalon-anterior diencephalon (DLX2 type), posterior diencephalon-midbrain (GATA2 type) and hindbrain-spinal cord (PTF1A and TAL1 types).
A link between Notch and progesterone maintains the functionality of the rat corpus luteum.
New
Tesone et al., Buenos Aires, Argentina. In Reproduction, Jan 2014
To demonstrate that the action of DAPT is specifically related with the inhibition of Notch, CLs were incubated with DLL4 antibody and a decrease in progesterone production was detected.
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
New
Impact
Buffa et al., Oxford, United Kingdom. In Cancer Cell, Sep 2013
This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling.
Robustness in angiogenesis: notch and BMP shaping waves.
Review
New
Zwijsen et al., Leuven, Belgium. In Trends Genet, Mar 2013
In particular, we focus on how Delta-like ligand 4 (DLL4)-Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip-stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs.
The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?
Review
Helewski et al., Katowice, Poland. In Contemp Oncol (pozn), 2012
One of the most prominent factors considered as a promising target in such therapy is the Notch ligand Delta-like 4 (DLL4).
The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy.
Review
O'Byrne et al., Dublin, Ireland. In J Thorac Oncol, 2012
However Smoothened inhibitors, gamma-secretase inhibitors, anti-DLL4 antagonists, Wnt antagonists, and CBP/β-catenin inhibitors have all shown promising anticancer effects in early studies.
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
GeneRIF
Aikawa et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
GeneRIF
Skokos et al., United States. In J Exp Med, 2012
Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration.
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Impact
Adams et al., Münster, Germany. In Nature, 2012
Signalling triggered by VEGF-A (also known as VEGF) has been shown to induce expression of the Notch ligand DLL4 in angiogenic vessels and, most prominently, in the tip of endothelial sprouts.
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.
Impact
Boehm et al., Germany. In Cell, 2012
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
GeneRIF
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
GeneRIF
Parreira et al., Lisbon, Portugal. In Plos One, 2011
This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis.
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
GeneRIF
Sergeeva et al., Moscow, Russia. In Plos One, 2011
Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Impact
Potente et al., Frankfurt am Main, Germany. In Nature, 2011
Consequently, endothelial cells lacking SIRT1 activity are sensitized to Notch signalling, resulting in impaired growth, sprout elongation and enhanced Notch target gene expression in response to DLL4 stimulation, thereby promoting a non-sprouting, stalk-cell-like phenotype.
Control of endothelial sprouting by a Tel-CtBP complex.
Impact
Baker et al., Leiden, Netherlands. In Nat Cell Biol, 2010
The Tel-CtBP complex temporally restricts a VEGF (vascular endothelial growth factor)-mediated pulse of dll4 expression and thereby directly links VEGF receptor intracellular signalling and intercellular Notch-Dll4 signalling.
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