Robustness in angiogenesis: notch and BMP shaping waves.
Leuven, Belgium. In Trends Genet, Mar 2013
In particular, we focus on how Delta-like ligand 4 (DLL4)-Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip-stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs.
Gonadal transactivation of STARD1, CYP11A1 and HSD3B.
Lubbock, United States. In Front Biosci, 2011
The steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme and specific 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerases initiate the essential process of steroidogenesis in the gonads.
Control of endothelial sprouting by a Tel-CtBP complex.
Leiden, Netherlands. In Nat Cell Biol, 2010
The Tel-CtBP complex temporally restricts a VEGF (vascular endothelial growth factor)-mediated pulse of dll4 expression and thereby directly links VEGF receptor intracellular signalling and intercellular Notch-Dll4 signalling.