GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 25 Jan 2016.
delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from
Khosrotehrani et al., Australia. In Stem Cells, 06 Feb 2016
Transcriptomic analysis identified cyclin-dependent kinase (CDK) cell cycle inhibiting genes (p16, p21, and p57), the Notch signaling pathway (dll1, dll4, hes1, and hey1), and the endothelial cytokine il33 as highly expressed in CD34 + ECFC.
Stanley et al., New York City, United States. In J Immunol, 01 Feb 2016
In this study, we show that Lfng/Mfng/Rfng triple knockout (Fng tKO) mice exhibited reduced binding of DLL4 Notch ligand to CD4/CD8 double-negative (DN) T cell progenitors, and reduced expression of NOTCH1 targets Deltex1 and CD25.
Xiao et al., Harbin, China. In Tumour Biol, 06 Dec 2015
UNASSIGNED: Delta-like ligand 4 (DLL4), one of the five Notch signaling ligands in mammals, has an important function in proliferation, invasion, metastasis, progression, and angiogenesis of malignancies.
Yin et al., Changsha, China. In Asian-australas J Anim Sci, Nov 2015
The expression of KiSS-1 metastasis-suppressor (KISS1), steroidogenic acute regulatory protein (StAR) and 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase (3β-HSD) was reduced (p<0.01) in SIF-supplemented groups.
Fowlkes et al., Bethesda, United States. In Immunity, Feb 2015
We have found that Delta Like Ligand 4 (DLL4)-induced Notch signaling potentiates phosphatidylinositol 3-OH kinase (PI3K)-dependent signaling downstream of the T cell receptor+CD28, allowing naive CD4(+) T cells to respond to lower doses of antigen.
We further demonstrated that this continuous regeneration process is mediated by Notch signaling and that the expression of the Notch ligand delta-like 4 (DLL4) in lacteals requires activation of VEGFR3 and VEGFR2.
Aikawa et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
Parreira et al., Lisbon, Portugal. In Plos One, 2011
This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis.