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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

Delta-like 4

delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, AGE, fibrillin-1
Papers on delta4
Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes.
New
Fischer et al., Heidelberg, Germany. In Stroke, 19 Apr 2015
CCM1- and CCM3-silenced endothelial cells have a reduced expression of the Notch ligand Delta-like 4 (DLL4) resulting in impaired Notch signaling and irregular sprouting angiogenesis.
The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.
New
Menendez et al., Granada, Spain. In Leukemia, 17 Apr 2015
We show that in hESCs the expression of the Notch ligand DLL4 is induced during hematopoietic differentiation.
Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
New
Impact
Garcia et al., Stanford, United States. In Science, 20 Mar 2015
The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study.
New
Cillo et al., Modena, Italy. In Gut, 09 Mar 2015
A five-gene transcriptomic hepatic signature including angiopoietin-2 (ANGPT2), delta-like ligand 4 (DLL4), neuropilin (NRP)/tolloid (TLL)-like 2 (NETO2), endothelial cell-specific molecule-1 (ESM1), and nuclear receptor subfamily 4, group A, member 1 (NR4A1) was found to accurately identify rapidly growing HCCs of the first quartile (ROC AUC: 0.961; 95% CI 0.919 to 1.000; p<0.0001) and to be an independent factor for mortality (HR: 3.987; 95% CI 1.941 to 8.193, p<0.0001).
Taking T cell priming down a Notch: signaling through Notch receptors enhances T cell sensitivity to antigen.
New
Impact
Butte et al., Stanford, United States. In Immunity, 20 Feb 2015
In this issue, Laky et al. (2015) show that Notch interactions with Delta-like ligand 4 (DLL4) amplify priming of naive T cells.
Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.
New
Impact
Fowlkes et al., Bethesda, United States. In Immunity, 20 Feb 2015
We have found that Delta Like Ligand 4 (DLL4)-induced Notch signaling potentiates phosphatidylinositol 3-OH kinase (PI3K)-dependent signaling downstream of the T cell receptor+CD28, allowing naive CD4(+) T cells to respond to lower doses of antigen.
Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity.
Review
New
Vidal-Puig et al., Córdoba, Spain. In Biochim Biophys Acta, Jan 2015
Here, we describe its function and dysregulation by factors such as oxidative stress, hypoxia and inflammation and provide evidence indicating that dihydroceramides constitute a biologically active molecule from the sphingolipid family with certain differential characteristics with respect to its delta-4 unsaturated counterparts, the ceramides.
The first implementation of IMRT technique for head & neck and prostate cancer patients in public sector in Greece: feasibility, treatment planning and dose delivery verification using the delta(4PT) Pre-Treatment volumetric quality assurance system.
New
Kouvaris et al., Athens, Greece. In J Buon, Jan 2015
The dose verification method used was based on the delta4(PT) Pre-Treatment volumetric quality assurance system, by Scadidos.
Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis.
New
Bonini et al., Milano, Italy. In J Immunol Res, Dec 2014
Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated.
Mechanisms regulating GABAergic neuron development.
Review
New
Partanen et al., Heidelberg, Germany. In Cell Mol Life Sci, Apr 2014
By comparing the molecular regulation of these events across CNS, we broadly identify three regions utilizing distinct molecular toolkits for GABAergic fate determination: telencephalon-anterior diencephalon (DLX2 type), posterior diencephalon-midbrain (GATA2 type) and hindbrain-spinal cord (PTF1A and TAL1 types).
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
Impact
Buffa et al., Oxford, United Kingdom. In Cancer Cell, 2013
This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling.
Robustness in angiogenesis: notch and BMP shaping waves.
Review
Zwijsen et al., Leuven, Belgium. In Trends Genet, 2013
In particular, we focus on how Delta-like ligand 4 (DLL4)-Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip-stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs.
The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?
Review
Helewski et al., Katowice, Poland. In Contemp Oncol (pozn), 2012
One of the most prominent factors considered as a promising target in such therapy is the Notch ligand Delta-like 4 (DLL4).
The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy.
Review
O'Byrne et al., Dublin, Ireland. In J Thorac Oncol, 2012
However Smoothened inhibitors, gamma-secretase inhibitors, anti-DLL4 antagonists, Wnt antagonists, and CBP/β-catenin inhibitors have all shown promising anticancer effects in early studies.
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
GeneRIF
Aikawa et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
GeneRIF
Skokos et al., United States. In J Exp Med, 2012
Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration.
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.
Impact
Boehm et al., Germany. In Cell, 2012
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
GeneRIF
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
GeneRIF
Parreira et al., Lisbon, Portugal. In Plos One, 2011
This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis.
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
GeneRIF
Sergeeva et al., Moscow, Russia. In Plos One, 2011
Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia.
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