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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 Mar 2014.

Delta-like 4

delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, AGE, fibrillin-1
Papers on delta4
Receptors of the Notch signaling pathway are associated with hemorrhage of brain arteriovenous malformations.
New
Zhao et al., Beijing, China. In Mol Med Report, 18 Apr 2014
The present study compared the expression levels of NOTCH1, NOTCH4 and two of their binding ligand genes, DLL4 and JAGGED1, in bAVM nidus and normal superficial temporal arteries (STAs) by quantitative polymerase chain reaction and immunohistochemical staining.
Endothelial Kruppel-like Factor 4 Regulates Angiogenesis and the Notch Signaling Pathway.
New
Hamik et al., United States. In J Biol Chem, 05 Apr 2014
Finally, we rescue Notch target gene expression and the KLF4 sprouting angiogenesis phenotype by supplementation of recombinant DLL4 protein.
NOTCH3 SIGNALING REGULATES MUSASHI-1 EXPRESSION IN METASTATIC COLORECTAL CANCER CELLS.
New
Indraccolo et al., Italy. In Cancer Res, 13 Mar 2014
Stimulation by the Notch ligand DLL4 was associated with an increase of Msi-1 mRNA and protein levels, and this phenomenon was prevented by the addition of antibody neutralizing Notch2/3 but not Notch1.
Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis.
New
Fearon et al., Dublin, Ireland. In Ann Rheum Dis, 13 Mar 2014
Notch-1 receptor, its DLL-4 ligand and downstream target genes (hrt-1, hrt-2) were quantified by real-time PCR.
A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
New
Impact
Buffa et al., Oxford, United Kingdom. In Cancer Cell, Sep 2013
This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling.
Robustness in angiogenesis: notch and BMP shaping waves.
Review
New
Zwijsen et al., Leuven, Belgium. In Trends Genet, Mar 2013
In particular, we focus on how Delta-like ligand 4 (DLL4)-Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip-stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs.
Organization of the human fetal subpallium.
Piroth et al., Freiburg, Germany. In Front Neuroanat, 2012
Our results reveal that DLX2 marks SVZ precursors in the entire subpallium.
The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy.
Review
O'Byrne et al., Dublin, Ireland. In J Thorac Oncol, 2012
However Smoothened inhibitors, gamma-secretase inhibitors, anti-DLL4 antagonists, Wnt antagonists, and CBP/β-catenin inhibitors have all shown promising anticancer effects in early studies.
The Notch ligand Delta-like 4 (DLL4) as a target in angiogenesis-based cancer therapy?
Review
Helewski et al., Katowice, Poland. In Contemp Oncol (pozn), 2012
One of the most prominent factors considered as a promising target in such therapy is the Notch ligand Delta-like 4 (DLL4).
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
GeneRIF
Aikawa et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Dll4 skewed macrophages toward a proinflammatory phenotype ("M1"). These results suggest that Dll4-Notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
Possible roles of DLK1 in the Notch pathway during development and disease.
Review
Gaemers et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2012
In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described.
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
GeneRIF
Skokos et al., United States. In J Exp Med, 2012
Anti-Dll4 treatment reverses established type 1 diabetes (T1D)and fully prevents T1D via a T(reg) cell-mediated mechanism and inhibits CD8(+) T cell pancreatic islet infiltration.
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Impact
Adams et al., Münster, Germany. In Nature, 2012
Signalling triggered by VEGF-A (also known as VEGF) has been shown to induce expression of the Notch ligand DLL4 in angiogenic vessels and, most prominently, in the tip of endothelial sprouts.
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.
Impact
Boehm et al., Germany. In Cell, 2012
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
GeneRIF
Zwijsen et al., Leuven, Belgium. In Dev Cell, 2012
The findings provide in vivo evidence for a regulatory loop between BMP/TGFbeta-Smad1/5 and Notch/dll4 signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity in angiogenesis.
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
GeneRIF
Parreira et al., Lisbon, Portugal. In Plos One, 2011
This study highlights a role for Dll4 in the quantitative regulation of early hemato-vascular precursors, further indicating that it is also involved on the timely emergence of mesoderm in early embryogenesis.
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
GeneRIF
Sergeeva et al., Moscow, Russia. In Plos One, 2011
Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia.
Gonadal transactivation of STARD1, CYP11A1 and HSD3B.
Review
LaVoie et al., Lubbock, United States. In Front Biosci, 2011
The steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme and specific 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerases initiate the essential process of steroidogenesis in the gonads.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Impact
Potente et al., Frankfurt am Main, Germany. In Nature, 2011
Consequently, endothelial cells lacking SIRT1 activity are sensitized to Notch signalling, resulting in impaired growth, sprout elongation and enhanced Notch target gene expression in response to DLL4 stimulation, thereby promoting a non-sprouting, stalk-cell-like phenotype.
Control of endothelial sprouting by a Tel-CtBP complex.
Impact
Baker et al., Leiden, Netherlands. In Nat Cell Biol, 2010
The Tel-CtBP complex temporally restricts a VEGF (vascular endothelial growth factor)-mediated pulse of dll4 expression and thereby directly links VEGF receptor intracellular signalling and intercellular Notch-Dll4 signalling.
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