Delta-like ligand 4-notch blockade and tumor radiation response.
Oxford, United Kingdom. In J Natl Cancer Inst, 2012
In DLL4-expressing CR carcinoma xngrft model, Notch blockade combined with ionizing radiation caused tumor growth delay. The DLL4 monoclnl antibody in combination with ionizing radiation also delayed tumor growth in the non-DLL4-expressing xngrft model
Gonadal transactivation of STARD1, CYP11A1 and HSD3B.
Lubbock, United States. In Front Biosci, 2011
The steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme and specific 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerases initiate the essential process of steroidogenesis in the gonads.
Control of endothelial sprouting by a Tel-CtBP complex.
Leiden, Netherlands. In Nat Cell Biol, 2010
The Tel-CtBP complex temporally restricts a VEGF (vascular endothelial growth factor)-mediated pulse of dll4 expression and thereby directly links VEGF receptor intracellular signalling and intercellular Notch-Dll4 signalling.
An essential developmental checkpoint for production of the T cell lineage.
Yokohama, Japan. In Science, 2010
We show that, when murine hematopoietic progenitors were cultured on immobilized Notch ligand DLL4 protein in the presence of a cocktail of cytokines including interleukin-7, progenitors developing toward T cells were arrested and the arrested cells entered a self-renewal cycle, maintaining non-T lineage potentials.