GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 17 Jun 2013.
Delta-like 4
delta4, Dlx2, Dll4
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
delta4
Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential.
New
Dublin, Ireland. In J Mol Biol, 27 Jun 2013
As proof of principle for the WySH2 libraries to produce viable lead candidate antibodies, 114 unique hits were produced against Delta-like ligand 4 (DLL4).
Effects of an Inhibitor of the Gamma-Secretase Complex on Proliferation and Apoptotic Parameters in a FOXL2-Mutated Granulosa Tumor Cell Line (KGN).
New
In Biol Reprod, 22 Jun 2013
We observed that JAGGED1, DLL4, NOTCH1 and NOTCH4 were highly expressed in KGN cells as compared to granulosa-lutein cells obtained from ART patients.
Increased expression of DLX2 correlates with advanced stage of gastric adenocarcinoma.
New
Kunming, China. In World J Gastroenterol, 07 Jun 2013
OBJECTIVE: To investigate the expression of distal-less homeobox 2 (DLX2) in gastric adenocarcinoma and its clinicopathological significance.
Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells.
New
Changsha, China. In J Surg Res, Mar 2013
RESULTS: VEGF-A (100 ng/mL) inhibited expression of EphB4 and stimulated expression of delta-like ligand 4 (dll4) but did not stimulate either notch or EphrinB2 expression in adult venous EC.
The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy.
Review
New
Dublin, Ireland. In J Thorac Oncol, Dec 2012
However Smoothened inhibitors, gamma-secretase inhibitors, anti-DLL4 antagonists, Wnt antagonists, and CBP/β-catenin inhibitors have all shown promising anticancer effects in early studies.
Distinct Functional and Temporal Requirements for Zebrafish Hdac1 during Neural Crest-Derived Craniofacial and Peripheral Neuron Development.
New
Columbus, United States. In Plos One, Dec 2012
First, fewer hoxb3a, dlx2 and dlx3-expressing posterior branchial arch precursors are specified and many of those that are consequently undergo apoptosis.
Possible roles of DLK1 in the Notch pathway during development and disease.
Review
New
Amsterdam, Netherlands. In Biochim Biophys Acta, Jun 2012
In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described.
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
New
Impact
Münster, Germany. In Nature, May 2012
Signalling triggered by VEGF-A (also known as VEGF) has been shown to induce expression of the Notch ligand DLL4 in angiogenic vessels and, most prominently, in the tip of endothelial sprouts.
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments.
New
Impact
Germany. In Cell, Apr 2012
Thymic epithelium that lacks hematopoietic function but is physiologically accessible for hematopoietic progenitor cells is functionalized by individual and combinatorial expression of four factors, the chemokines Ccl25 and Cxcl12, the cytokine Scf, and the Notch ligand DLL4.
Delta-like ligand 4-notch blockade and tumor radiation response.
GeneRIF
Oxford, United Kingdom. In J Natl Cancer Inst, 2012
In DLL4-expressing CR carcinoma xngrft model, Notch blockade combined with ionizing radiation caused tumor growth delay. The DLL4 monoclnl antibody in combination with ionizing radiation also delayed tumor growth in the non-DLL4-expressing xngrft model
Gonadal transactivation of STARD1, CYP11A1 and HSD3B.
Review
Lubbock, United States. In Front Biosci, 2011
The steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme and specific 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerases initiate the essential process of steroidogenesis in the gonads.
Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina.
GeneRIF
Rochester, United States. In Neuroscience, 2011
Brn-3b suppresses the role of DLX1/2 through physical interaction and biases the competent precursors toward retinal ganglion cell fates.
Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis.
GeneRIF
Basel, Switzerland. In Embo J, 2011
Dlx2 is one critical player in shifting TGFbeta from its tumour suppressive to its tumour-promoting functions.
The preTCR-dependent DN3 to DP transition requires Notch signaling, is improved by CXCL12 signaling and is inhibited by IL-7 signaling.
GeneRIF
Basel, Switzerland. In Eur J Immunol, 2011
double-negative 3 (DN3) thymocytes only require a Delta-like-4-induced Notch signal to differentiate into double-positive (DP) cells.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Impact
Frankfurt am Main, Germany. In Nature, 2011
Consequently, endothelial cells lacking SIRT1 activity are sensitized to Notch signalling, resulting in impaired growth, sprout elongation and enhanced Notch target gene expression in response to DLL4 stimulation, thereby promoting a non-sprouting, stalk-cell-like phenotype.
At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17.
Review
Minsk, Belarus. In Biochim Biophys Acta, 2011
CYP17 catalyzes the 17alpha-hydroxylation reaction of delta4-C₂₁ steroids (progesterone derivatives) and delta5-C₂₁ steroids (pregnenolone derivatives) as well as the 17,20-lyase reaction producing C₁₉-steroids, a key branch point in steroid hormone biosynthesis.
Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis.
GeneRIF
Pusan, South Korea. In Mol Cancer, 2010
Dlx-2 may be involved in tumor progression via the regulation of metabolic stress-induced necrosis
Control of endothelial sprouting by a Tel-CtBP complex.
Impact
Leiden, Netherlands. In Nat Cell Biol, 2010
The Tel-CtBP complex temporally restricts a VEGF (vascular endothelial growth factor)-mediated pulse of dll4 expression and thereby directly links VEGF receptor intracellular signalling and intercellular Notch-Dll4 signalling.
Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies).
Review
In Natl Toxicol Program Tech Rep Ser, 2010
Synonyms: Andro; androst-4-ene-3,17-dione; 4-androstene-3,17-dione; delta-4-androstene-3,17-dione; delta-4-androstenedione; 3,17-dioxoandrost-4-ene; 17-ketotestosterone; SKF 2170 Trade names: Androtex, Fecundin.
An essential developmental checkpoint for production of the T cell lineage.
Impact
Yokohama, Japan. In Science, 2010
We show that, when murine hematopoietic progenitors were cultured on immobilized Notch ligand DLL4 protein in the presence of a cocktail of cytokines including interleukin-7, progenitors developing toward T cells were arrested and the arrested cells entered a self-renewal cycle, maintaining non-T lineage potentials.
