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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Delta-like 1

delta1, Dll1, DeltaI, DL1, Delta-like 1
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, p300
Papers using delta1 antibodies
Position effect and related phenomena
Supplier
Höglund Petter et al., In The Journal of Experimental Medicine, 1991
... The DL1 transgenic line has previously been ...
Papers on delta1
Midostaurin, bortezomib and MEC in relapsed/refractory acute myeloid leukemia.
New
Marcucci et al., Columbus, United States. In Leuk Lymphoma, Feb 2016
Patients on dose levels 1 and 2 (DL1 & 2) received midostaurin 50 mg bid and escalating doses of bortezomib (1 to 1.3 mg/m2).
Melanoma immunotherapy in mice using genetically engineered pluripotent stem cells.
New
Song et al., In Cell Transplant, Feb 2016
The gene-transduced iPSCs were cultured on the delta-like ligand 1-expressing OP9 (OP9-DL1) murine stromal cells in the presence of murine recombinant cytokines (rFlt3L and rIL-7) for a week.
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.
New
Remaut et al., Brussels, Belgium. In Cell Host Microbe, Feb 2016
Two diversity loops, DL1 and DL2, provide adaptive control to binding affinity, notably ABO versus O bg preference.
Self-Renewal and High Proliferative Colony Forming Capacity of Late-Outgrowth Endothelial Progenitors is Regulated by Cyclin-Dependent Kinase Inhibitors Driven by Notch Signaling.
New
Khosrotehrani et al., Australia. In Stem Cells, Feb 2016
Transcriptomic analysis identified cyclin-dependent kinase (CDK) cell cycle inhibiting genes (p16, p21, and p57), the Notch signaling pathway (dll1, dll4, hes1, and hey1), and the endothelial cytokine il33 as highly expressed in CD34 + ECFC.
Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells.
New
Subramaniam et al., Kansas City, United States. In Oncotarget, Jan 2016
Furthermore, levels of Notch 1-4 receptors, their ligands Jagged1, Jagged2, DLL1, DLL3, DLL4 and the downstream target protein Hes-1 were reduced.
The role and interaction of imprinted genes in human fetal growth.
Review
New
Stanier et al., London, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, Apr 2015
Analysis of the paternally expressing delta-like 1 homologue (DLK1) shows that the paternal transmission of type 1 diabetes protective G allele of rs941576 single nucleotide polymorphism (SNP) results in significantly reduced birth weight (-132 g).
Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer.
Review
New
Sood et al., Oxford, United Kingdom. In Clin Cancer Res, Apr 2015
The canonical Notch pathway with four Notch receptors (Notch1-4) and five ligands (DLL1, 3-4, Jagged 1-2) is an evolutionarily conserved cell signaling pathway that plays critical roles in cell-fate determination, differentiation, development, tissue patterning, cell proliferation, and death.
Membrane curvature modulation of protein activity determined by NMR.
Review
Schlame et al., Hamilton, Canada. In Biochim Biophys Acta, 2015
Among the examples discussed are antimicrobial peptides, proteins affecting membrane fusion, rhodopsin, protein kinase C, phospholipase C-delta1, phosphatidylinositol-3 kinase-related kinases and tafazzin.
[Opioids--triggers of adaptive phenomenon of ischemic preconditioning of heart].
Review
Tsibul'nikov et al., In Ross Fiziol Zh Im I M Sechenova, 2014
Agonists of mu-, delta1- delta- and kappa1-opioid receptors mimic the cardioprotective effect of preconditioning.
An update on the contribution of the MHC to AS susceptibility.
Review
Reveille, Houston, United States. In Clin Rheumatol, 2014
The best evidence is for major histocompatibility complex class I chain-related gene A (MICA) whose recognition by intestinal epithelial T cells expressing different V-delta-1 gamma/delta TCR further implicates the gut in AS pathogenesis.
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1.
Impact
Weber et al., München, Germany. In Nat Med, 2014
Here we show that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation.
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
Impact
Cerutti et al., Barcelona, Spain. In Nat Immunol, 2014
Splenic ILCs established bidirectional crosstalk with MAdCAM-1(+) marginal reticular cells by providing tumor-necrosis factor (TNF) and lymphotoxin, and they stimulated MZ B cells via B cell-activation factor (BAFF), the ligand of the costimulatory receptor CD40 (CD40L) and the Notch ligand Delta-like 1 (DLL1).
Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells.
Impact
Kawamoto et al., Yokohama, Japan. In Cell Stem Cell, 2013
When cocultured with OP9/DLL1 cells, these iPSCs efficiently generated TCRβ(+)CD4(+)CD8(+) double positive (DP) cells expressing a T cell receptor (TCR) specific for the MART-1 epitope.
Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation.
GeneRIF
Van Valckenborgh et al., In Leukemia, 2012
Dll1 and Notch interaction accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation.
Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis.
GeneRIF
Limbourg et al., Hannover, Germany. In Circ Res, 2012
Dll1 acts as an extrinsic cue involved in tip cell selection, which directs vessel sprouting and branch formation.
Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling.
GeneRIF
Stanley et al., New York City, United States. In J Biol Chem, 2012
the presence of Gal on O-fucose glycans differentially affects DLL1-induced NOTCH signaling modulated by LFNG versus MFNG
Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.
GeneRIF
Serup et al., Denmark. In Development, 2012
Ptf1a-induced Dll1 expression stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining Hes1 expression and Ptf1a protein levels.
Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer.
GeneRIF
Ricciardiello et al., Bologna, Italy. In Oncotarget, 2011
Notch1 activity in gastric cancer is controlled by the epigenetic silencing of the ligand DLL1, and that Notch1 inhibition is associated with the diffuse type of gastric cancer.
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway.
Impact
GeneRIF
Barbry et al., Antibes, France. In Nat Cell Biol, 2011
Notch1 and its ligand Delta-like 1(DLL1) are miR-449 bona fide targets
Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer.
Impact
Chau et al., United Kingdom. In J Clin Oncol, 2009
PATIENTS AND METHODS: Patients with untreated, unresectable, locally advanced or metastatic pancreatic carcinoma were enrolled onto one of the following four sequential dose levels (DLs) of escalating capecitabine doses (days 1 to 21): DL1, 910 mg/m(2); DL2, 1,160 mg/m(2); DL3, 1,400 mg/m(2); or DL4, 1,660 mg/m(2).
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