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Fatty acid desaturase 2

delta-6-desaturase, FADS2, D6D
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, FADS1, HAD, CAN, AGE
Papers on delta-6-desaturase
Detection of Acyl-CoA Derivatized with Butylamide for in vitro Fatty Acid Desaturase Assay.
New
Aki et al., Hiroshima, Japan. In J Oleo Sci, Feb 2016
To set up the in vitro reaction, we traced the in vivo activity of rat liver ∆6 fatty acid desaturase (D6d) expressed in the yeast, Saccharomyces cerevisiae, and determined the time taken for the D6d activity to reach its maximum level.
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
New
Ling et al., Copenhagen, Denmark. In Diabetologia, Feb 2016
RESULTS: We found differential DNA methylation at 53 sites in SAT from LBW vs normal birthweight (NBW) men (false discovery rate <5%), including sites in the FADS2 and CPLX1 genes previously associated with type 2 diabetes.
Activity, Expression and Substrate Preference of the Δ6-Desaturase in Slow- or Fast-growing Rabbit Genotypes.
New
Terova et al., In J Agric Food Chem, Feb 2016
UNASSIGNED: In the present paper liver fatty acid Δ6 desaturation (fads2) activity was analyzed in two rabbit strains with slow- (S, 27.5 g/d) or fast-growing (F, 48.5 g/d) rate.
Fatty acid composition of chicken breast meat is dependent on genotype-related variation of FADS1 and FADS2 gene expression and desaturating activity.
New
Sirri et al., Bologna, Italy. In Animal, Jan 2016
Slow (SG), medium (MG) and fast (FG) growing chickens fed the same diet were evaluated either for the relative expression of FADS1, FADS2 and SCD1 genes in liver (by q-PCR), or for the FA composition of breast meat.
Biosynthesis of Essential Polyunsaturated Fatty Acids in Wheat Triggered by Expression of Artificial Gene.
Kraic et al., Piešťany, Slovakia. In Int J Mol Sci, 2014
The artificial gene D6D encoding the enzyme ∆⁶desaturase was designed and synthesized using the sequence of the same gene from the fungus Thamnidium elegans.
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Impact
Zheng et al., Nashville, United States. In Nat Genet, 2014
Four other loci are located in or near genes involved in transcriptional regulation (ZMIZ1), genome maintenance (FEN1), fatty acid metabolism (FADS1 and FADS2), cancer cell motility and metastasis (CD9), and cell growth and differentiation (NXN).
Unsaturated fatty acids, desaturases, and human health.
Review
Park et al., Ch'ŏnan, South Korea. In J Med Food, 2014
The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.
Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease.
Review
Martinelli et al., Verona, Italy. In Adv Exp Med Biol, 2013
Delta-5 (D5D) and delta-6 desaturases (D6D), encoded respectively by FADS1 and FADS2 genes, are the rate-limiting enzymes for PUFA conversion and are recognized as main determinants of PUFA levels.
A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.
GeneRIF
Brenna et al., Ithaca, United States. In J Lipid Res, 2012
discovery and function of a novel FADS1 splice variant
Nutritional aspects of epigenetic inheritance.
Review
Hungin et al., Delhi, India. In Can J Physiol Pharmacol, 2012
Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.
Interactions between dietary n-3 fatty acids and genetic variants and risk of disease.
Review
Ordovás et al., Valencia, Spain. In Br J Nutr, 2012
Greater consistency was observed in studies that involved the FADS1 and FADS2 locus in the determination of n-3 fatty acid concentrations in biological samples.
Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.
GeneRIF
Davey Smith et al., Bristol, United Kingdom. In Hum Mol Genet, 2012
Strong associations of two FADS2 SNPs with levels of polyunsaturated fatty acids.
Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression.
GeneRIF
Calder et al., Southampton, United Kingdom. In Prostaglandins Leukot Essent Fatty Acids, 2012
Changes in progesterone and oestradiol during pregnancy may promote the synthesis of LC PUFA via increased FADS2 expression.
Recent insights into the relation of Δ5 desaturase and Δ6 desaturase activity to the development of type 2 diabetes.
Review
Schulze et al., Potsdam, Germany. In Curr Opin Lipidol, 2012
Furthermore, studies on genetic variation in the FADS1 and FADS2 genes, which encode D5D and D6D, also point to an influence of D5D and D6D activity on glucose metabolism.
Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats.
GeneRIF
Joshi et al., Pune, India. In Prostaglandins Leukot Essent Fatty Acids, 2012
Data show that an imbalance of maternal micronutrients increases Delta5 desaturase activity but decreases mRNA levels, decreases Delta6 desaturase activity but not mRNA levels as compared to control.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Impact
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids.
GeneRIF
Brenna et al., Ithaca, United States. In Plos One, 2010
The loss of FADS2-encoded activities in cancer cells shuts down normal polyunsaturated fatty acid biosynthesis.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
Impact
ENGAGE Consortium et al., Rotterdam, Netherlands. In Nat Genet, 2009
The six newly identified loci in our cohort samples are ABCG5 (TC, P = 1.5 x 10(-11); LDL, P = 2.6 x 10(-10)), TMEM57 (TC, P = 5.4 x 10(-10)), CTCF-PRMT8 region (HDL, P = 8.3 x 10(-16)), DNAH11 (LDL, P = 6.1 x 10(-9)), FADS3-FADS2 (TC, P = 1.5 x 10(-10); LDL, P = 4.4 x 10(-13)) and MADD-FOLH1 region (HDL, P = 6 x 10(-11)).
Common variants at 30 loci contribute to polygenic dyslipidemia.
Impact
Cupples et al., Boston, United States. In Nat Genet, 2009
The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP.
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
Impact
Peltonen et al., Los Angeles, United States. In Nat Genet, 2009
We replicate most previously reported associations for these traits and identify nine new associations, several of which highlight genes with metabolic functions: high-density lipoprotein with NR1H3 (LXRA), low-density lipoprotein with AR and FADS1-FADS2, glucose with MTNR1B, and insulin with PANK1.
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