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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

EGF-like repeats and discoidin I-like domains 3

Del1, developmental endothelial locus-1
The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, V1a, Epidermal Growth Factor
Papers on Del1
DEL1 - a new player in periodontal disease?
New
Voronov, Toronto, Canada. In Oral Dis, Feb 2016
UNASSIGNED: Osteoclasts are multinucleated cells responsible for bone resorption.
Core cell cycle regulatory genes in rice and their expression profiles across the growth zone of the leaf.
New
Beemster et al., Szeged, Hungary. In J Plant Res, Nov 2015
However genes such as different D-type cyclins, DEL1, KRP1/3, and RBR2 were also expressed in leaf segments representing the transition zone in which cells start differentiation.
DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates.
New
Hajishengallis et al., Philadelphia, United States. In Sci Transl Med, Oct 2015
DEL-1 (developmental endothelial locus-1) is an endothelial cell-secreted protein that regulates LFA-1 (lymphocyte function-associated antigen-1) integrin-dependent leukocyte recruitment and inflammation in various tissues.
Crosstalk between bone marrow-derived mesenchymal stem cells and regulatory T cells through a glucocorticoid-induced leucine zipper/developmental endothelial locus-1-dependent mechanism.
New
Shi et al., Augusta, United States. In Faseb J, Sep 2015
We show that expression of glucocorticoid (GC)-induced leucine zipper (GILZ) in bone marrow mesenchymal lineage cells or bone marrow-derived mesenchymal stem cells (BMSCs) increases the production of T(reg) cells via a mechanism involving the up-regulation of developmental endothelial locus-1 (Del-1), an endogenous leukocyte-endothelial adhesion inhibitor.
Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination.
New
Chavakis et al., Seoul, South Korea. In Mol Psychiatry, Jul 2015
We have previously identified developmental endothelial locus-1 (Del-1) as an endogenous anti-inflammatory factor, which inhibits integrin-dependent leukocyte adhesion.
Genotyping of Pneumocystis jirovecii isolates from human immunodeficiency virus-negative patients in China.
New
Gu et al., Beijing, China. In Infect Genet Evol, Apr 2015
Six known ITS1 alleles (A, B, DEL1, E, N, and SYD1), two new alleles (designated as BTM3 and BTM4), six known ITS2 alleles (a, b, i, g, h and O) and one new allele (designated as btm6) were observed.
A role for Taiman in insect metamorphosis.
Belles et al., Barcelona, Spain. In Plos Genet, 2014
Reporter assays indicated that both T. castaneum Tai isoforms, one that contains the IN-1 and another that does not (DEL-1) activated a JH response element (kJHRE) in Krüppel homolog 1 in conjunction with Met and JH.
Mesenchymal stem cell-based developmental endothelial locus-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice.
Wu et al., Shanghai, China. In Mol Med Report, 2014
Developmental endothelial locus-1 (Del-1) is a critical factor for cell migration and infiltration via the inhibition of the function of a major leukocyte adhesion receptor LFA-1 which prevents leukocyte adhesion to the endothelium.
Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
Wildermuth et al., Berkeley, United States. In Cell Host Microbe, 2014
Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity.
The RGD finger of Del-1 is a unique structural feature critical for integrin binding.
GeneRIF
Wang et al., Boston, United States. In Faseb J, 2012
database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1
DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity.
GeneRIF
Inzé et al., Gent, Belgium. In Plant Physiol, 2012
Overexpression of DEL1 does not completely abolish early endoreduplication on stress.
Leucocyte recruitment in inflammation and novel endogenous negative regulators thereof.
Review
Chavakis, Dresden, Germany. In Eur J Clin Invest, 2012
Endogenous negative regulators include for instance pentraxin-3 (PTX-3) that blocks selectin-dependent leucocyte rolling, or the endothelium-derived developmental endothelial locus-1 (Del-1) that antagonizes beta2-integrin-mediated firm adhesion of leucocytes to the endothelium.
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss.
Impact
GeneRIF
Hajishengallis et al., Louisville, United States. In Nat Immunol, 2012
Del-1 suppressed LFA-1-dependent recruitment of neutrophils and IL-17-triggered inflammatory pathology and may thus be a promising therapeutic agent for inflammatory diseases.
Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium.
GeneRIF
Thiagarajan et al., Houston, United States. In Circulation, 2012
Del-1 plays a physiological role in the clearance of phosphatidylserine-expressing microparticles by endothelium.
Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc.
GeneRIF
De Veylder et al., Gent, Belgium. In Plant Physiol, 2011
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
Endothelial dysfunction: methods of assessment & implications for cardiovascular diseases.
Review
Lip et al., Birmingham, United Kingdom. In Curr Pharm Des, 2009
In addition to regulating vasomotion, the healthy endothelium also has anti-thrombotic (through prostacyclins), anti-inflammatory (through developmental endothelial locus-1{Del-1}) and anti-proliferative (through NO and prostaglandin I2) properties.
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.
Impact
GeneRIF
Chavakis et al., Bethesda, United States. In Science, 2008
study describes Del-1 as an anti-adhesive factor that interferes with the integrin LFA-1-dependent leukocyte-endothelial adhesion; Del-1 is an endogenous inhibitor of inflammatory cell recruitment
Mechanotransduction: touch and feel at the molecular level as modeled in Caenorhabditis elegans.
Review
Bianchi, Miami, United States. In Mol Neurobiol, 2007
The C. elegans genome encodes 28 DEG/ENaC channels: I discuss here the global role of DEG/ENaCs in mechanosensation, reporting findings on the role of other three nematode DEG/ENaCs (UNC-8, DEL-1, and UNC-105) in mechanosensitive and stretch-sensitive behaviors.
MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure.
Review
Nagata et al., Ōsaka, Japan. In Curr Dir Autoimmun, 2005
Milk fat globule-EGF factor 8 (MFG-E8) and developmental endothelial locus-1 (Del-1) are glycoproteins secreted from macrophages that pass apoptotic cells to phagocytes.
Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans.
Review
Driscoll et al., New Brunswick, United States. In Annu Rev Physiol, 1996
Two other degenerins, UNC-8 and DEL-1, are candidate components of a stretch-sensitive channel in motor neurons.
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