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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Defensin, alpha 1

Defensin, cryptdin-1, Cryptdin
Top mentioned proteins: ACID, CAN, hBD-2, HAD, POLYMERASE
Papers on Defensin
Administration of Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) and Avian Beta Defensin as Adjuvants in Inactivated Inclusion Body Hepatitis Virus and its Hexon Protein-Based Experimental Vaccine Formulations in Chickens.
New
Tikoo et al., Canada. In Avian Dis, Dec 2015
However, based on the excellent safety and immunogenic profiles of experimental veterinary vaccines developed with the use of new generation adjuvants, we hypothesized that characterization of vaccine formulations containing inactivated IBHV or its capsid protein hexon as antigens, along with poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) and avian beta defensin 2 (ABD2) as vaccine adjuvants, will be helpful in development of an effective and safe vaccine formulation for IBH.
Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System.
New
Millhauser et al., Santa Cruz, United States. In Biophys J, Dec 2015
Human β-defensin 3 (HBD3), which is produced in the skin, has been found to bind to melanocortin receptors 1 and 4 through complementary electrostatics, a unique mechanism of ligand-receptor interaction.
Association of Higher Defensin β-4 Genomic Copy Numbers with Behçet's Disease in Iraqi Patients.
New
Norgauer et al., Baghdad, Iraq. In Sultan Qaboos Univ Med J, Nov 2015
Human β-defensins are antimicrobial peptides associated with many inflammatory diseases and are encoded by the β-defensin family of multiple-copy genes.
α-Defensin Accuracy to Diagnose Periprosthetic Joint Infection-Best Available Test?
New
Higuera et al., Cleveland, United States. In J Arthroplasty, Oct 2015
BACKGROUND: The purpose of this study was to test the accuracy of a single synovial fluid biomarker, α-defensin, in diagnosing periprosthetic joint infection in revision total hip and revision total knee arthroplasty).
Two Cheers for Crohn's Disease and Periodontitis: Beta-Defensin-2 as an Actionable Target to Intervene on Two Clinically Distinct Diseases.
Review
New
Gursoy et al., Turku, Finland. In Omics, Aug 2015
Furthermore, we propose a novel connector molecular target between these two ostensibly distinct diseases at a clinical level, human beta defensin (hBD)-2, and suggest pathways by which hBD-2 can conceivably connect Crohn's disease and periodontitis by virtue of regulating the innate-immune response.
iDPF-PseRAAAC: A Web-Server for Identifying the Defensin Peptide Family and Subfamily Using Pseudo Reduced Amino Acid Alphabet Composition.
Fan et al., Hohhot, China. In Plos One, 2014
To identify specific defensins as interesting antifungal leads, in this study, we constructed a more rigorous benchmark dataset and the iDPF-PseRAAAC server was developed to predict the defensin family and subfamily.
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses.
Review
Ottolini et al., Leicester, United Kingdom. In Front Immunol, 2014
Defensin genes reside in complex genomic regions that are prone to structural variations and some defensin family members exhibit copy number variation (CNV).
Black Tea Extract and Its Theaflavin Derivatives Inhibit the Growth of Periodontopathogens and Modulate Interleukin-8 and β-Defensin Secretion in Oral Epithelial Cells.
Grenier et al., São Paulo, Brazil. In Plos One, 2014
Since few data are available concerning the beneficial properties of black tea and its theaflavin derivatives against periodontal disease, the objective of this study was to investigate their antibacterial activity as well as their ability to modulate interleukin-8 and human β-defensin (hBD) secretion in oral epithelial cells.
Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma.
Gibson et al., Newcastle, Australia. In Mediators Inflamm, 2014
Innate immune antimicrobial peptides, including β-defensin-1, promote the chemotaxis and activation of several immune cells.
Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells.
Myung et al., Seoul, South Korea. In Plos One, 2014
UNASSIGNED: Previously, using the Illumina HumanHT-12 microarray we found that β-defensin 131 (DEFB131), an antimicrobial peptide, is upregulated in the human prostate epithelial cell line RWPE-1 upon stimulation with lipoteichoic acid (LTA; a gram-positive bacterial component), than that in the untreated RWPE-1 cells.
Bovine β-defensin gene family: opportunities to improve animal health?
Review
O'Farrelly et al., Ireland. In Physiol Genomics, 2014
Recent analysis of the bovine genome revealed an expanded suite of β-defensin genes that encode what are referred to as antimicrobial or host defense peptides (HDPs).
Defensin-based anti-infective strategies.
Review
Sahl et al., Bonn, Germany. In Int J Med Microbiol, 2014
Cationic and amphiphilic peptides are widely distributed in eukaryotic organisms and constitute a first line of host defense against invading pathogens.
[Defensins in the honeybee antinfectious protection].
Review
Nikolenko et al., In Zh Evol Biokhim Fiziol, 2012
In the honeybee, defensins are present in the form of two different peptides--defensin 1 and 2 that are similar between each other only by 55.8 %.
Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice.
GeneRIF
Kohgo et al., Asahikawa, Japan. In Inflamm Bowel Dis, 2010
Decreased alpha-defensin is associated with intestinal inflammation in a model of inflammatory bowel disease.
Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid cells.
Impact
Higashiyama et al., Nagoya, Japan. In Nature, 2009
Here we report that secreted, cysteine-rich polypeptides (CRPs) in a subgroup of defensin-like proteins are attractants derived from the synergid cells.
Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity.
GeneRIF
Ouellette et al., Irvine, United States. In J Biol Chem, 2006
MMP-7 activates mouse paneth cell pro-alpha-defensins
Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?
GeneRIF
Lu et al., Baltimore, United States. In J Biol Chem, 2006
the Arg5-Glu13 salt bridge in alpha-defensin is conserved for defensin in vivo stability
Mouse intestinal cryptdins exhibit circadian oscillation.
GeneRIF
Miskin et al., Jerusalem, Israel. In Faseb J, 2005
cryptdin-1 and cryptdin-4 exhibit circadian oscillation
IL-22 increases the innate immunity of tissues.
Impact
Sabat et al., Berlin, Germany. In Immunity, 2004
In these cells, IL-22 activated STAT3 and directly and transcriptionally increased the expression of beta-Defensin 2 and beta-Defensin 3. High levels of IL-22 were associated with strongly upregulated beta-Defensin expression in skin from patients with T cell-mediated dermatoses.
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