Papers on
DEDD2
Tandem DEDs and CARDs suggest novel mechanisms of signaling complex assembly.Tung et al., Tainan City, Taiwan. In Apoptosis, Feb 2015
There are seven DED-containing proteins in human, including FADD, c-FLIP, caspase-8, caspase-10, DEDD, DEDD2, and PEA-15.
Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells.Wan et al., Sacramento, United States. In Biochem Pharmacol, 2013
However, fenretinide specifically induced Fas/TNFα-mediated apoptosis by increasing the expression of pro-apoptotic genes i.e., DEDD2, CASP8, CASP4, and HSPA1A/B; whereas, ATRA induced the expression of BIRC3 and TNFAIP3, which inhibit apoptosis by interacting with TRAF2.
Death effector domain-containing proteins.Ramos et al., Honolulu, United States. In Cell Mol Life Sci, 2009
The seven standard DED-containing proteins are fas associated death domain protein (FADD), Caspase-8 and 10, cellular FLICE-like inhibitory protein (c-FLIP), death effector domain containing DNA binding (DEDD), DEDD2 and phosphoprotein enriched in astrocytes 15-Kda (PEA-15).