gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

C-type lectin domain family 4, member n

Dectin-2, Nkcl
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: Dectin-1, CAN, V1a, Interleukin-6, IL-10
Papers using Dectin-2 antibodies
Pathways Regulating Cytosolic Phospholipase A2 Activation and Eicosanoid Production in Macrophages by Candida albicans*
Supplier
Leslie Christina C. et al., In The Journal of Biological Chemistry, 2005
... Anti-Dectin-2 monoclonal antibody D2.11E4 was generated as described previously (15), and isotype control rat-IgG2a was obtained from BioLegend.
Papers on Dectin-2
Rescue of CD8+ T cell vaccine memory following sublethal γ irradiation.
New
Rosenberg et al., Silver Spring, United States. In Vaccine, Aug 2015
A number of these factors, including IL-36γ, dectin-2 (Clec4n), and mir101c are upregulated rapidly after exposure of mice to sublethal γ radiation alone and are sustained by early, but not later rescue.
Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural killer cell lymphoma.
New
Chan et al., Beijing, China. In Clin Cancer Res, May 2015
PURPOSE: To identify tumor suppressor genes epigenetically silenced by promoter hypermethylation in extranodal natural killer cell lymphoma (NKCL).
Neutrophil priming occurs in a sequential manner and can be visualized in living animals by monitoring IL-1β promoter activation.
New
Takashima et al., Toledo, United States. In J Immunol, Mar 2015
GeneChip analyses unveiled elevated CD54, dectin-2, and IL-1β mRNA expression by neutrophils isolated from inflammatory sites.
Recognition of Aspergillus fumigatus hyphae by human plasmacytoid dendritic cells is mediated by dectin-2 and results in formation of extracellular traps.
New
Levitz et al., São Paulo, Brazil. In Plos Pathog, Feb 2015
Our data show that Dectin-2, but not Dectin-1, participates in A. fumigatus hyphal recognition, TNF-α and IFN-α release, and antifungal activity.
Specificity of the Immunomodulating Activity of Sasa veitchii (Japanese Folk Medicine Kumazasa) to Fungal Polysaccharides.
Ohno et al., Tokyo, Japan. In Int J Med Mushrooms, 2014
BWMP inhibited the production of interferon gamma (IFN-γ) by not only toll like receptors (TLRs), but also the C-type lectin receptors (CLRs) dectin-1 and dectin-2.
Neither dectin-2 nor the mannose receptor is required for resistance to Coccidioides immitis in mice.
Fierer et al., San Diego, United States. In Infect Immun, 2014
We investigated the roles of the mannose receptor (MR) and Dectin-2 in resistance to pulmonary coccidioidomycosis in C57BL/6 (B6) mice and in the interaction of myeloid cells with spherules, using B6 mice with targeted mutations in Mrc1 and Clec4n.
Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.
Impact
Pearlman et al., Cleveland, United States. In Nat Immunol, 2014
IL-6 and IL-23 induced expression of the receptors IL-17RC and dectin-2 on neutrophils, and IL-17RC expression was augmented by activation of dectin-2.
IL-12 secretion by Langerhans cells stimulated with Candida skin test reagent is mediated by dectin-1 in some healthy individuals.
Nagarajan et al., Little Rock, United States. In Cytokine, 2014
METHODS: The following immunological features were studied to understand how Candida induces immune responses in healthy subjects: (1) proliferative capacity of T-cells upon exposure to Candida through monocyte-derived human Langerhans cells (LCs) measured using alamarBlue, (2) cytokine (IL-1β, IL-6, IL-8, IL-10, IL-12p40, IL-23Ap19, IFN-γ, and TNF- expression upon Candida stimulation of LCs by quantitative reverse transcription (qRT)-PCR and cytokine secretion by ELISA, (3) expression of pattern recognition receptors (PRRs) known to associate with Candida albicans (DC-SIGN, dectin-1, dectin-2, galectin-3, mincle, mannose receptor, Toll-like receptors 1, 2, 4, 6, and 9) on LCs by qRT-PCR, (4) role of dectin-1 in IL-12 production by antibody blocking, and (5) induction of Th1, Th2, and/or Th17 responses by intracellular cytokine staining of CD4 cells exposed to Candida pulsed LCs for IFN-γ, IL-4, and IL-17A.
Candida skin test reagent as a novel adjuvant for a human papillomavirus peptide-based therapeutic vaccine.
Nakagawa et al., Shenyang, China. In Vaccine, 2014
The presence of pattern recognition receptors known to associate with Candida albicans (DC-SIGN, dectin-1, dectin-2, galectin-3, mincle, mannose receptor, Toll-like receptors-1, 2, 4, 6 and 9) were demonstrated in all subjects.
β-mannosyl linkages inhibit CAWS arteritis by negatively regulating dectin-2-dependent signaling in spleen and dendritic cells.
Ohno et al., Nagano, Japan. In Immunopharmacol Immunotoxicol, 2013
It is a ligand of dectin-2, the C-type lectin receptor for innate immunity, and has strong potency for induction of vasculitis in DBA/2 mice.
Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses.
GeneRIF
Lin et al., Houston, United States. In J Biol Chem, 2012
PLCgamma2 deficiency impairs Dectin-2-induced NF-kappaB and MAPK activation in response to fungal infection
Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.
GeneRIF
Geijtenbeek et al., Amsterdam, Netherlands. In Plos Pathog, 2010
Thus, dectin-1 and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1-dependent activation of c-Rel.
Allergen-specific pattern recognition receptor pathways.
Review
Wills-Karp, Cincinnati, United States. In Curr Opin Immunol, 2010
Although the identification of allergen-specific pattern recognition receptors is in its infancy, studies to date have shown that allergens drive Th2-biased immune responses via directly engaging C-type lectin receptors (dectin-2, DC-SIGN, and mannose receptor) on dendritic cells and/or mimicking toll-like receptor 4 signaling complex molecules expressed on airway structural cells.
Severe Candida spp. infections: new insights into natural immunity.
Review
Netea et al., Nijmegen, Netherlands. In Int J Antimicrob Agents, 2010
The major pathogen-associated molecular patterns of Candida are mannoproteins, glucans and chitins, which are recognised by C-type lectin pattern recognition receptors such as the mannose receptor, dectin-1 and dectin-2.
CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.
GeneRIF
Lin et al., Houston, United States. In J Biol Chem, 2010
CARD9 is selectively involved in Dectin-2-induced NF-kappaB activation in response to C. albicans hyphae challenging.
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.
Impact
GeneRIF
Iwakura et al., Tokyo, Japan. In Immunity, 2010
Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
GeneRIF
Reis e Sousa et al., London, United Kingdom. In J Exp Med, 2009
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.
Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2.
Review
Cruz et al., Dallas, United States. In Glycobiology, 2009
This knowledge, in turn, prompted us to review such interactions with emphasis on C-type lectin receptors and a focus on the roles of dectin-1 and dectin-2 in anti-fungal immunity.
Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells.
Review
Kanazawa, Wakayama, Japan. In J Dermatol Sci, 2007
The genes of other homologous DC-associated C-type lectin receptors, dectin-2 and blood DC antigen (BDCA)-2, form a cluster with those of DCIR and DCAR, while the dectin-1 gene cluster contains lectin-like oxidized low-density lipoprotein receptor (LOX)-1, C-type lectin-like receptor (CLEC)-1 and 2, as well as MICL.
Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2.
Review
Miyachi et al., Kyoto, Japan. In Immunobiology, 2003
Two other lectins, dectin-2 and BDCA-2, are highly related to DCAR by similarities of their amino acid sequence, molecular structure and chromosomal localization.
share on facebooktweetadd +1mail to friends