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C-type lectin domain family 7, member A

Dectin-1, beta-glucan receptor
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLR2, V1a, CAN, Interleukin-6, Syk
Papers using Dectin-1 antibodies
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Underhill David M. et al., In The Journal of Experimental Medicine, 1990
... The dectin-1 coding region was fused to the 3′ end of eGFP (CLONTECH Laboratories, Inc.) by PCR ...
Papers on Dectin-1
MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.
Dinarello et al., Milano, Italy. In Proc Natl Acad Sci U S A, Feb 2016
Specifically, production of IFN-γ on stimulation of dectin-1, mannose, and Toll-like receptors with Candida albicans and Staphylococcus epidermidis was 2.5- and 2.9-fold higher in high-risk subjects than in low-risk subjects, respectively (P = 0.007 and P = 0.01).
Polymorphisms of the immune-modulating receptor dectin-1 in pigs: their functional influence and distribution in pig populations.
Uenishi et al., Tsukuba, Japan. In Immunogenetics, Feb 2016
Here, we assessed the genetic diversity in the gene encoding dectin-1 (CLEC7A) within various pig populations and examined the influence of these polymorphisms on the two different signaling pathways after ligand recognition.
Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-1.
Mochizuki et al., Toyama, Japan. In Exp Dermatol, Feb 2016
Previously, we established a mouse model of Trichophyton-induced contact hypersensitivity (CHS) and demonstrated that dectin-1 was involved in inflammation induced by trichophytin, the Trichophyton antigen.
Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects.
Kuijpers et al., Amsterdam, Netherlands. In J Immunol, Jan 2016
Recognition of conidia involves integrin CD11b/CD18 (and not dectin-1), which triggers a PI3K-dependent nonoxidative intracellular mechanism of killing.
Reactive oxygen species production by human dendritic cells involves TLR2 and dectin-1 and is essential for efficient immune response against Mycobacteria.
Alemán et al., Buenos Aires, Argentina. In Cell Microbiol, Jan 2016
Here we show that Mtb induces DC maturation through TLR2/dectin-1 by generating of ROS and through DC-SIGN in a ROS-independently manner.
Trained immunity: A smart way to enhance innate immune defence.
Netea et al., Nijmegen, Netherlands. In Mol Immunol, Nov 2015
We have discovered that both BCG (via NOD2 signalling) and β-glucan (via dectin-1) induce epigenetic reprogramming, in particular stable changes in histone trimethylation at H3K4.
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Xiao et al., Shanghai, China. In Nat Immunol, Jun 2015
Mechanistically, SHP-2 operated as a scaffold, facilitating the recruitment of Syk to the CLR dectin-1 or the adaptor FcRγ, through its N-SH2 domain and a previously unrecognized carboxy-terminal immunoreceptor tyrosine-based activation motif (ITAM).
Exploiting fungal cell wall components in vaccines.
Specht et al., Worcester, United States. In Semin Immunopathol, Mar 2015
Best studied is β-1,3-glucan, a glycan that activates complement and is recognized by dectin-1.
Caspases as the key effectors of inflammatory responses against bacterial infection.
Tsutsui et al., Nishinomiya, Japan. In Arch Immunol Ther Exp (warsz), Feb 2015
In contrast to caspase-1, caspase-8 is activated by receptors located on the plasma membrane including dectin-1, TLR-3/4, and Fas.
Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens.
Papayannopoulos et al., London, United Kingdom. In Nat Immunol, 2014
Phagocytosis via dectin-1 acted as a sensor of microbe size and prevented NET release by downregulating the translocation of neutrophil elastase (NE) to the nucleus.
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
Netea et al., Nijmegen, Netherlands. In Science, 2014
Trained monocytes display high glucose consumption, high lactate production, and a high ratio of nicotinamide adenine dinucleotide (NAD(+)) to its reduced form (NADH), reflecting a shift in metabolism with an increase in glycolysis dependent on the activation of mammalian target of rapamycin (mTOR) through a dectin-1-Akt-HIF-1α (hypoxia-inducible factor-1α) pathway.
Immune correlates of protection in human invasive aspergillosis.
Husain et al., Toronto, Canada. In Clin Infect Dis, 2014
Fungal recognition via pattern recognition receptors, such as pentraxin 3, dectin-1, and Toll-like receptors, leads to complement activation, phagocytosis, and killing of ingested fungi.
Innate immunity induced by fungal β-glucans via dectin-1 signaling pathway.
Kim et al., Seoul, South Korea. In Int J Med Mushrooms, 2013
Innate immune cells express pattern recognition receptors (PRRs) such as dectin-1, Toll-like receptors, and mannose receptors on their cell surfaces.
Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity.
Umetsu et al., Boston, United States. In Nat Med, 2013
Although A. fumigatus is recognized by multiple microbial pattern-recognition receptors, we found that an A. fumigatus-derived glycosphingolipid, asperamide B, directly activates invariant natural killer T (iNKT) cells in vitro in a CD1d-restricted, MyD88-independent and dectin-1-independent fashion.
The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.
Coste et al., Toulouse, France. In Immunity, 2013
Here, we report that the macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors (CLRs) signature composed of Dectin-1, mannose receptor (MR), and the DC-SIGN homolog SIGNR3 expression.
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
Peters-Golden et al., Ann Arbor, United States. In J Immunol, 2012
Signaling by leukotriene B4 and its receptor controls dectin-1 transcription via granulocyte macrophage colony stimulating factor (GM-CSF) and transcription factor PU.1.
Relative contributions of dectin-1 and complement to immune responses to particulate β-glucans.
Levitz et al., Worcester, United States. In J Immunol, 2012
Dectin-1 is dispensable for antibody and CD4-positive T cell responses to antigen-loaded particulate beta-glucans in vivo.
IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals.
Kwon et al., Ulsan, South Korea. In J Immunol, 2012
Dectin-1 signaling increases the phagocytic activity of neutrophils through upregulation of CD11b expression.
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.
Underhill et al., Los Angeles, United States. In Science, 2012
findings show that the gut contains a fungal community that interacts with the immune system through the innate immune receptor Dectin-1; mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Dalpke et al., Heidelberg, Germany. In J Immunol, 2012
SOCS1 is expressed via a new, NF-kappaB-independent pathway in Dectin-1-triggered murine bone marrow macrophages and influences Toll-like receptor cross-talk and T cell priming.
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