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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Decorin, PGII
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, AGE, fibrillin-1
Papers on Decorin
Tenogenic induction of equine mesenchymal stem cells by means of growth factors and low-level laser technology.
Spaas et al., Padova, Italy. In Vet Res Commun, Feb 2016
PB-MSCs were used to study the effects of the addition of some growth factors (GFs) as TGFβ3 (transforming growth factor), EGF2 (Epidermal growth factor), bFGF2 (Fibroblast growth factor) and IGF-1 (insulin-like growth factor) in presence or without Low Level Laser Technology (LLLT) on the mRNA expression levels of genes important in the tenogenic induction as Early Growth Response Protein-1 (EGR1), Tenascin (TNC) and Decorin (DCN).
Oxyntic gastric atrophy in Helicobacter pylori gastritis is distinct from autoimmune gastritis.
Malfertheiner et al., Magdeburg, Germany. In J Clin Pathol, Feb 2016
Serum gastrin-17 (G17), pepsinogen (PG) I, PGII and antibodies against H. pylori and cytotoxin-associated gene A protein were determined in all patients.
Restraint of Trophoblast Invasion of the Uterus by Decorin: Role in Pre-eclampsia.
Lala et al., London, Canada. In Am J Reprod Immunol, Dec 2015
UNASSIGNED: Decorin (DCN) is a leucine-rich, TGF-β binding proteoglycan produced by mesenchymal cells including chondrocytes, dermal fibroblasts, and uterine decidual cells.
DCN deficiency promotes renal cell carcinoma growth and metastasis through downregulation of P21 and E-cadherin.
Zhou et al., Nanjing, China. In Tumour Biol, Dec 2015
UNASSIGNED: Decorin (DCN), as an important component of the extracellular matrix (ECM), is a small leucine-rich proteoglycan and synthesized by fibroblasts.
Effect of adipose-derived mesenchymal stromal cells on tendon healing in aging and estrogen deficiency: an in vitro co-culture model.
Fini et al., Bologna, Italy. In Cytotherapy, Nov 2015
Decorin and Tenascin C expression increased in the presence of OVX ADSCs.
Helicobacter pylori Stool Antigen Levels and Serological Biomarkers of Gastric Inflammation are Associated with Cardio-Metabolic Risk Factors in Type 2 Diabetic Patients.
Azizi et al., Tehrān, Iran. In Endocrinol Metab (seoul), Sep 2015
Pearson correlation test, linear, and logarithmic regression curve estimation models were used to assess the association of H. pylori stool antigen (HpSAg) levels, and pepsinogen I (PGI) to pepsinogen II (PGII) ratio with fasting serum glucose, insulin, serum lipid and lipoprotein parameters, malondialdehyde, high-sensitive C-reactive protein (hs-CRP), systolic and diastolic blood pressure, body weight, waist circumference and lipid accumulation product (LAP) index.
Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A.
Wang et al., Galveston, United States. In Biochemistry, Sep 2015
Decorin binding protein A (DBPA) is a glycosaminoglycan (GAG)-binding adhesin found on the surface of the bacterium Borrelia burgdorferi (B.
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors.
Iozzo et al., Philadelphia, United States. In Biochemistry, Sep 2015
Decorin and biglycan evoke autophagy and immunological responses that deter, suppress, or exacerbate pathological conditions such as tumorigenesis, angiogenesis, and chronic inflammatory disease.
Decorin Reduces Intraocular Pressure and Retinal Ganglion Cell Loss in Rodents Through Fibrolysis of the Scarred Trabecular Meshwork.
Logan et al., Birmingham, United Kingdom. In Invest Ophthalmol Vis Sci, Jun 2015
PURPOSE: To investigate whether Decorin, a matrikine that regulates extracellular matrix (ECM) deposition, can reverse established trabecular meshwork (TM) fibrosis, lower IOP, and reduce progressive retinal ganglion cell (RGC) death in a novel rodent model of TM fibrosis.
Ll et al., In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, Apr 2015
Real-time fluorescent quantitative PCR results showed that the mRNA expressions of the tendon/ligament-specific genes (Tenomodulin, Tenascin-C, and Decorin) in the transfected group were significantly higher than those in untransfected group (0.061+/- 0.013 vs. 0.004 +/- 0.002, t = -7.700,
Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition.
Prince et al., Tampere, Finland. In Biomed Res Int, 2014
Decorin (DCN) is the best characterized member of the extracellular small leucine-rich proteoglycan family present in connective tissues, typically in association with or "decorating" collagen fibrils.
Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi.
Seshu et al., College Station, United States. In Plos One, 2014
Immunoblot analysis revealed reduced levels of Outer surface protein C (OspC), Decorin binding protein A (DbpA), fibronectin binding protein (BBK32), RpoS and BosR in the sodA mutant compared to the control strains.
Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors.
Nishinakamura et al., Kumamoto, Japan. In Sci Rep, 2014
We found that Decorin, which inhibits Bmp-mediated nephron differentiation, was upregulated in the mutant stroma.
Decorin treatment of spinal cord injury.
Ahmed et al., Birmingham, United Kingdom. In Neural Regen Res, 2014
Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars.
Dynamic reduction of plasma decorin following ischemic stroke: a pilot study.
Liu et al., Shanghai, China. In Neurochem Res, 2012
There is a dynamic reduction in Decorin level the days following ischemic stroke, and the decrement persists at least the first 2 weeks
Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon.
Soslowsky et al., Philadelphia, United States. In J Biomech Eng, 2012
decorin plays a role in tendon viscoelasticity that cannot be completely explained by its role in collagen fibrillogenesis
OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level.
Zhang et al., Shanghai, China. In Plos One, 2011
Data show that the overexpression of OTUB1 enhanced the ubiquitination and degradation of Decorin (DCN)in mesangial cells (MC).
Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival.
Done et al., Toronto, Canada. In Plos One, 2011
These analyses identified decorin (DCN) and endoplasmin (HSP90B1) which play important roles regulating the tumour microenvironment and in pathways related to tumorigenesis.
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.
Granville et al., Vancouver, Canada. In Plos One, 2011
Data show that granzyme B (GrB) liberated TGF-beta1 from substrates decorin, biglycan and betaglycan.
[Study on the progress of the mechanism of TGF-beta in the scarring and the effect of TCM].
Zhang et al., Beijing, China. In Zhongguo Gu Shang, 2008
A number of regulators of TGF-beta expression bave been identified, including Decorin CTGF, etc. TCM can reduced later scarring, and it accelerates wound healing.
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