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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lymphocyte antigen 75

DEC-205, CD205
Top mentioned proteins: MHC, CAN, CD11c, CD86, CD4
Papers on DEC-205
Development of a more efficient hepatitis B virus vaccine by targeting hepatitis B virus preS to dendritic cells.
Liu et al., Wuhan, China. In Vaccine, Feb 2016
We investigated whether the preS-cSA protein could target dendritic cells (DCs) by binding a biotinylated antibody against the DC receptor CD205 (biotin-αCD205).
Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice.
Redmond et al., Portland, United States. In Proc Natl Acad Sci U S A, Feb 2016
Animals treated with combination therapy and vaccination using anti-DEC-205 (dendritic and epithelial cells, 205 kDa)-HER2 (human epidermal growth factor receptor 2) had significantly improved survival in a mammary carcinoma model.
A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract.
Mehandru et al., New York City, United States. In Mucosal Immunol, Feb 2016
Our results show that nasally delivered α-CD205-p24 vaccine in combination with polyICLC, induced polyfunctional immune responses within naso-pulmonary lymphoid sites that disseminated widely to systemic and mucosal (GI tract and the vaginal epithelium) sites.
IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites.
Westendorf et al., Essen, Germany. In Mucosal Immunol, Feb 2016
Here we show that antigen targeting to DEC-205 on dendritic cells leads to an interleukin (IL)-10-dependent downregulation of C-X-C chemokine receptor 3 (CXCR3) expression on differentiated antigen-specific T helper type 1 (Th1) cells in vivo.
(1)H, (13)C and (15)N resonance assignments of human DCL-1 (CD302) extracellular domain.
Chmelík et al., Praha, Czech Republic. In Biomol Nmr Assign, Feb 2016
More interestingly it is alternatively expressed in the form of a fusion protein with another single-pass type one transmembrane protein DEC205 (CD205) which is normally involved in antigen-uptake and endocytosis.
Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers.
Kalinke et al., Hannover, Germany. In Eur J Pharm Biopharm, Sep 2015
Examples of CLR expressed by APCs include DEC-205 (CD205) expressed by myeloid dendritic cells (DC) and monocytes, the mannose receptor C type 1 (MR, CD206) expressed by DC, monocytes and macrophages, DC-SIGN (CD209) expressed by DC, and several others.
Targeting human dendritic cells in situ to improve vaccines.
Dhodapkar et al., New Haven, United States. In Immunol Lett, 2014
Recent clinical studies describing in situ DC targeting with antibody-mediated targeting of DC receptor through DEC-205 provide new opportunities for the clinical application of DC-targeted vaccines.
A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.
Porcelli et al., United States. In Immunity, 2014
Here we have shown that a single type of cell, the CD8α(+) DEC-205(+) dendritic cell, was mainly responsible for capturing and presenting a variety of different glycolipid antigens, including multiple forms of α-galactosylceramide that stimulate widely divergent cytokine responses.
Integrating genetic association, genetics of gene expression, and single nucleotide polymorphism set analysis to identify susceptibility Loci for type 2 diabetes mellitus.
Hu et al., Boston, United States. In Am J Epidemiol, 2012
The most significantly associated SNPs to type 2 diabetes mellitus in this study are expression SNPs to the lymphocyte antigen 75 gene, the ubiquitin-specific peptidase 36 gene, and the phosphatidylinositol transfer protein, cytoplasmic 1 gene.
Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo.
Sato et al., Yokohama, Japan. In Proc Natl Acad Sci U S A, 2012
CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo
Targeting tumor antigens to dendritic cells using particulate carriers.
Mastrobattista et al., Downers Grove, United States. In J Control Release, 2012
Utilization of different ligands such as mannose, Fc receptor, CD11c/CD 18, DEC-205 and DC-SIGN on DC for active targeting is reviewed.
Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses.
Romani et al., Innsbruck, Austria. In J Immunol, 2012
Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation.
Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells.
Drew et al., Cincinnati, United States. In Clin Exp Metastasis, 2011
Upregulation of LY75 is associated with ovarian tumor.
Targeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccination.
Kretschmer et al., Dresden, Germany. In Rev Diabet Stud, 2011
Dendritic cells (DCs) and Foxp3-expressing CD4⁺ regulatory T (Treg) cells play non-redundant roles in the maintenance of peripheral tolerance to self-antigens, thereby preventing fatal autoimmunity.
Filamentous bacteriophage fd as an antigen delivery system in vaccination.
De Berardinis et al., Napoli, Italy. In Int J Mol Sci, 2011
The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205.
Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.
Caminschi et al., Melbourne, Australia. In J Immunol, 2011
For production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.
Differential antigen processing by dendritic cell subsets in vivo.
Nussenzweig et al., New York City, United States. In Science, 2007
Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.
Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo.
Dustin et al., New York City, United States. In Nat Immunol, 2005
We targeted ovalbumin peptide exclusively to DCs in situ using an antibody to DEC-205 and studied the interaction of DCs with naive CD4(+) T cells in tolerizing or priming conditions.
RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells.
Shortman et al., Melbourne, Australia. In Immunity, 1998
Here, we report that RelB mRNA is expressed strongly in CD8alpha- DEC-205- DC but only weakly in CD8alpha+ DEC-205+ DC.
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing.
Nussenzweig et al., New York City, United States. In Nature, 1995
We show here that their antigen-presentation function is associated with the high-level expression of DEC-205, an integral membrane protein homologous to the macrophage mannose receptor and related receptors which are able to bind carbohydrates and mediate endocytosis.
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