GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Discoidin domain receptor tyrosine kinase 2
DDR2, discoidin domain receptor 2
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
CAN, EGFR, HAD, V1a, POLYMERASE
Papers on
DDR2
May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for?
New
Jackson, United States. In J Mol Cell Cardiol, Feb 2016
UNASSIGNED: In a recent issue of Journal of Molecular and Cellular Cardiology, George et al. [1] identified discoidin domain receptor 2 (DDR2) as a positive modulator of collagen production in cardiac fibroblasts stimulated with angiotensin II (Ang II).
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.
New
In J Clin Invest, Feb 2016
Genes that were mutated in more than one metastatic or recurrent tumor, but not in the respective primary tumors, include C17orf104, inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3), and discoidin domain receptor tyrosine kinase 2 (DDR2).
Molecular basis and functional significance of Angiotensin II-induced increase in Discoidin Domain Receptor 2 gene expression in cardiac fibroblasts.
New
Thiruvananthapuram, India. In J Mol Cell Cardiol, Jan 2016
This study probed the regulation of Discoidin Domain Receptor 2 (DDR2) gene expression and the regulatory links between Angiotensin II, DDR2 and collagen in Angiotensin II-stimulated cardiac fibroblasts.
Evaluation of discoidin domain receptor-2 (DDR2) expression level in normal, benign, and malignant human prostate tissues.
New
Tehrān, Iran. In Res Pharm Sci, Jul 2015
There are two isoforms of discoidin domain receptor (DDR), DDR1 and DDR2.
Beyond EGFR and ALK inhibition: unravelling and exploiting novel genetic alterations in advanced non small-cell lung cancer.
Review
New
Manchester, United Kingdom. In Cancer Treat Rev, May 2015
Nevertheless, in the recent years a number of other oncogenic drivers beyond EGFR and ALK inhibition have emerged as novel molecular targets with potential therapeutic implications, including mutations in the genes KRAS, BRAF, HER2, PI3KCA and DDR2, as well as ROS1 and RET rearrangements and MET, HER2 and FGFR1 gene amplifications.
Small molecule discoidin domain receptor kinase inhibitors and potential medical applications.
Review
New
Guangzhou, China. In J Med Chem, May 2015
Two types of DDRs, DDR1 and DDR2, have been identified with distinct expression profiles and ligand specificities.
Mutation Profiling of Lung Cancers with Long-Term Response to Gefitinib Therapy.
Luzern, Switzerland. In Oncol Res Treat, 2014
Next generation sequencing revealed no further EGFR-mutated cases, but reported in 15 (94%) of the tumors mutations in other genes (ALK, BRAF, DDR2, KEAP1, MET, PTEN, STK11) previously associated with NSCLC.
Primary Pulmonary Mucoepidermoid Carcinoma: Histopathological and Moleculargenetic Studies of 26 Cases.
Beijing, China. In Plos One, 2014
Mutation profiling of the EGFR, KRAS, BRAF, ALK, PIK3CA, PDGFRA, and DDR2 genes were carried out using next-generation sequencing (NGS), Sanger sequencing, and quantitative polymerase chain reaction (QPCR) in 9 successfully amplified cases.
Beyond adenocarcinoma: current treatments and future directions for squamous, small cell, and rare lung cancer histologies.
Review
Dallas, United States. In Am Soc Clin Oncol Educ Book, 2014
For squamous tumors, the most promising of these include fibroblast growth factor receptor (FGFR), the phosphatidylinositol 3-kinase (PI3K) pathway, discoidin domain receptor 2 (DDR2), and G1/S checkpoint regulators.
Targeted Therapies in Non-Small Cell Lung Cancer-Beyond EGFR and ALK.
Review
Basel, Switzerland. In Cancers (basel), 2014
The scope of this review is to discuss recent data on novel molecular targets as ROS1, BRAF, KRAS, HER2, c-MET, RET, PIK3CA, FGFR1 and DDR2.
Molecular testing in lung cancer in the era of precision medicine.
Review
Graz, Austria. In Transl Lung Cancer Res, 2014
After EGFR several other driver genes such as echinoderm microtubule associated protein like 4-AL-Kinase 1 (EML4-ALK1), c-ros oncogene 1, receptor tyrosine kinase (ROS1), discoidin domain receptor tyrosine kinase 2 (DDR2), fibroblast growth factor receptor 1 (FGFR1) were discovered, and more to come.
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
Impact
Saint Louis, United States. In Nat Cell Biol, 2013
We show that activation of the collagen I receptor DDR2 (discoidin domain receptor 2) regulates SNAIL1 stability by stimulating ERK2 activity, in a Src-dependent manner.
New targetable oncogenes in non-small-cell lung cancer.
Review
Impact
Boston, United States. In J Clin Oncol, 2013
A number of new potentially oncogenic gene alterations have been characterized in recent years, including BRAF mutations, HER2 insertions, PIK3CA mutations, FGFR1 amplifications, DDR2 mutations, ROS1 rearrangements, and RET rearrangements.
Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis.
GeneRIF
Sierra Leone. In Gut, 2012
DDR2 deficiency predisposes hepatic tissue to colon carcinoma metastasis. DDR2 deficiency fosters myofibroblast transdifferentiation of tumour-activated hepatic stellate cells (HSCs), generating a prometastatic microenvironment in the liver.
Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy.
Review
Impact
New York City, United States. In Lancet Oncol, 2012
Additionally, evidence of unique biology has emerged with the discovery of SOX2 amplification, NFE2L2 and KEAP1 mutations, PI3K pathway changes, FGFR1 amplification, and DDR2 mutations.
Identification of common variants associated with human hippocampal and intracranial volumes.
Impact
Los Angeles, United States. In Nat Genet, 2012
We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3;
Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability.
GeneRIF
Spain. In Oncol Rep, 2011
DDR2 promotes A375 melanoma metastasis to the liver and the underlying mechanism implicates regulation of metalloproteinase release, cell growth and chemotactic invasion of the host tissue.
Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition.
GeneRIF
Boston, United States. In Matrix Biol, 2011
Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition
Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts.
GeneRIF
Horsham, United Kingdom. In J Biol Chem, 2011
Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts.
Expression of discoidin domain receptors (DDR2) in alcoholic liver fibrosis in rats.
GeneRIF
Liaocheng, China. In Arch Med Res, 2010
Data show that the expression of DDR2 is closely associated with collagens in the fibrotic liver tissues.
