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Damage-specific DNA binding protein 2, 48kDa

DDB2
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DDB1, XPC, p53, CAN, Ubiquitin
Papers using DDB2 antibodies
Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH
Supplier
Dantuma Nico P. et al., In The Journal of Cell Biology, 2005
GFP-DDB2 plasmid and the packaging/envelope plasmids pMDLg/pRRE, pRSV-REV, and pCMV-VSV-G using polyethylenimine (Polysciences, Inc.) ...
Papers on DDB2
Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks.
New
Yuan et al., Shenyang, China. In Oncotarget, Feb 2016
The results demonstrated that DDB2 rs830083 GG genotype was significantly associated with increased GC risk compared with wild-type CC (OR=2.32,
Differential DNA lesion formation and repair in heterochromatin and euchromatin.
New
Wani et al., Columbus, United States. In Carcinogenesis, Jan 2016
In addition, we also showed that the repair of CPD in heterochromatin is slower than that in euchromatin, and DNA damage binding protein 2 (DDB2) can promote the removal of CPD from heterochromatic region.
A DDB2 mutant protein unable to interact with PCNA promotes cell cycle progression of human transformed embryonic kidney cells.
New
Cazzalini et al., Pavia, Italy. In Cell Cycle, Jan 2016
DNA damage binding protein 2 (DDB2) is a protein involved in the early step of DNA damage recognition of the nucleotide excision repair (NER) process.
Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER Consortium.
New
Ambrosone et al., Los Angeles, United States. In Int J Cancer, Jan 2016
Gene-level analyses identified associations with risk for several genes at a nominal p ≤ 0.05, particularly for ER- breast cancer, including rs4647707 in DDB2.
Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro.
New
Shah et al., New York City, United States. In Sci Rep, Dec 2015
In addition, using the model oligonucleotides with single UV lesion surrounded by multiple restriction enzyme sites, we demonstrate in vitro that DDB2 and PARP-1 can simultaneously bind to UV-damaged DNA and that PARP-1 casts a bilateral asymmetric footprint from -12 to +9 nucleotides on either side of the UV-lesion.
The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies.
Review
Zhou et al., New York City, United States. In Ai Zheng, 2013
Cullin 4A (CUL4A) is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting substrates including damage-specific DNA-binding protein 2 (DDB2), xeroderma pigmentosum complementation group C (XPC), chromatin licensing and DNA replication factor 1 (Cdt1), and p21.
DDB2 promotes chromatin decondensation at UV-induced DNA damage.
GeneRIF
Dantuma et al., Stockholm, Sweden. In J Cell Biol, 2012
study reports a new function of DDB2 in modulating chromatin structure at DNA lesions
p21 cooperates with DDB2 protein in suppression of ultraviolet ray-induced skin malignancies.
GeneRIF
Raychaudhuri et al., Chicago, United States. In J Biol Chem, 2012
the anti-proliferative and the pro-senescence pathways of DDB2 and p21 are critical protection mechanisms against skin malignancies.
Damaged DNA binding protein 2 in reactive oxygen species (ROS) regulation and premature senescence.
Review
Raychaudhuri et al., Chicago, United States. In Int J Mol Sci, 2011
Here, we discuss how Damaged DNA binding Protein-2 (DDB2), a nucleotide excision repair protein, plays an important role in ROS regulation by epigenetically repressing the antioxidant genes MnSOD and Catalase.
Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions.
Review
Bevilacqua et al., Napoli, Italy. In Int J Biochem Cell Biol, 2011
DDB1 and DDB2 form a complex that promotes the global genome repair (GG-NER), whereas DDB1 and Cockayne syndrome group A protein (CSA) form a complex that contributes to the transcription-coupled repair (TC-NER) pathway.
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Impact
Thomä et al., Basel, Switzerland. In Cell, 2011
The DCAF DDB2 detects UV-induced pyrimidine dimers in the genome and facilitates nucleotide excision repair.
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA.
GeneRIF
Naegeli et al., Zürich, Switzerland. In Plos Biol, 2011
DDB2 subunit of UV-DDB associates transiently with the DNA-binding domain of XPC to fine-tune its engagement with CPD lesions
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Review
GeneRIF
Thomä et al., Basel, Switzerland. In Febs Lett, 2011
Studies indicate the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 in DNA repair of UV-induced DNA lesions.
XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.
Review
Tainer et al., Berkeley, United States. In Dna Repair (amst), 2011
NER is initiated by arrested RNA polymerase or damage recognition by XPC-RAD23B with or without DDB1/DDB2.
Nucleotide excision repair proteins rapidly accumulate but fail to persist in human XP-E (DDB2 mutant) cells.
GeneRIF
Kraemer et al., Bethesda, United States. In Photochem Photobiol, 2011
Nucleotide excision repair proteins rapidly accumulate but fail to persist in human xeroderma pigmentosum XP-E (DDB2 mutant) cells.
Here comes the sun: recognition of UV-damaged DNA.
Impact
Yang et al., Stanford, United States. In Cell, 2009
In this issue, Scrima et al. (2008) report the structure of the complex of DNA Damage-Binding Protein 1 (DDB1) and DDB2 bound to a DNA photodimer, providing critical insight into the repair of DNA damage caused by ultraviolet light.
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Impact
GeneRIF
Thomä et al., Basel, Switzerland. In Cell, 2009
The structure DDB1-DDB2 complex shows the tightly localized probing of the photolesions, combined with proofreading in the photodimer pocket, enables DDB2 to detect lesions refractory to detection by other damage surveillance proteins.
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Impact
GeneRIF
Nakatani et al., Boston, United States. In Cell, 2003
DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1
BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.
Impact
Ford et al., Stanford, United States. In Nat Genet, 2002
Here we show that BRCA1 specifically enhances the GGR pathway, independent of p53, and can induce p53-independent expression of the NER genes XPC, DDB2, and GADD45.
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