Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro.
New York City, United States. In Sci Rep, Dec 2015
In addition, using the model oligonucleotides with single UV lesion surrounded by multiple restriction enzyme sites, we demonstrate in vitro that DDB2 and PARP-1 can simultaneously bind to UV-damaged DNA and that PARP-1 casts a bilateral asymmetric footprint from -12 to +9 nucleotides on either side of the UV-lesion.
Here comes the sun: recognition of UV-damaged DNA.
Stanford, United States. In Cell, 2009
In this issue, Scrima et al. (2008) report the structure of the complex of DNA Damage-Binding Protein 1 (DDB1) and DDB2 bound to a DNA photodimer, providing critical insight into the repair of DNA damage caused by ultraviolet light.