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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Damage-specific DNA binding protein 1, 127kDa

DDB1, UV-DDB, XPE, UV-damaged DNA-binding protein
This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, DDB2, Cullin, CAN, Cul4A
Papers using DDB1 antibodies
Human immunodeficiency virus type 1 Vpr protein does not modulate surface expression of the CD4 receptor
Früh Klaus, In PLoS Pathogens, 2001
... The mouse monoclonal antibody against DDB1 was obtained from BD Biosciences ( ...
Papers on DDB1
Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins.
Pitt et al., Birmingham, United Kingdom. In Free Radic Biol Med, Jan 2016
Altered binding to PTEN was confirmed by affinity pull-down and Western blotting for Prdx1, Trx, and Anxa2, while DDB1 was validated as a novel interactor with unaltered binding.
The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications.
Ren et al., Tianjin, China. In Oncotarget, Jan 2016
CRL4 E3 ubiquitin ligase, as one member of CRLs family, consists of a RING finger domain protein, cullin4 (CUL4) scaffold protein and DDB1-CUL4 associated substrate receptors.
Exome sequencing revealed a novel biallelic deletion in the DCAF17 gene underlying Woodhouse Sakati syndrome (WSS).
Ahmad et al., Islamabad, Pakistan. In Clin Genet, Dec 2015
Structural analysis of truncated DCAF17 revealed absence of amino acid residues crucial for interaction with DDB1.
Genome-wide redistribution of H3K27me3 is linked to genotoxic stress and defective growth.
Lewis et al., Athens, United States. In Proc Natl Acad Sci U S A, Dec 2015
In Neurospora crassa, a single H3K9 methyltransferase complex, called the DIM-5,-7,-9, CUL4, DDB1 Complex (DCDC), is required for normal growth and development.
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B.
Zhou et al., United States. In Gene, Dec 2015
CRL4 function is vital to cells as loss of both genes or their shared substrate adaptor protein DDB1 halts proliferation and eventually leads to cell death.
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
Ebert et al., Boston, United States. In Nature, Aug 2015
Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)), resulting in CK1α degradation.
Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome.
Kurumizaka et al., Tokyo, Japan. In Sci Rep, 2014
UV-DDB, an initiation factor for the nucleotide excision repair pathway, recognizes 6-4PP lesions through a base flipping mechanism.
The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis.
Aifantis et al., New York City, United States. In Elife, 2014
Here we characterize the role of Ddb1, a component of the CUL4-DDB1 ubiquitin ligase complex.
Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system.
Slagle et al., Houston, United States. In Viruses, 2014
We summarize here the interactions of HBx with components of the UPS, including the CUL4 adaptor DDB1, the cullin regulatory complex CSN, and the 26S proteasome.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Thomä et al., Basel, Switzerland. In Nature, 2014
IMiDs target the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)) and promote the ubiquitination of the IKAROS family transcription factors IKZF1 and IKZF3 by CRL4(CRBN).
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Yamagata et al., Kumamoto, Japan. In Cell Metab, 2014
Biochemical studies revealed that the DDB1-CUL4-associated factor 1 (DCAF1)/damage-specific DNA binding protein 1 (DDB1)/cullin 4B (CUL4B) E3 ubiquitin ligase complex interacted with TR4, leading to its degradation, while binding of SIRT7 to the DCAF1/DDB1/CUL4B complex inhibited the degradation of TR4.
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.
Benkirane et al., Montpellier, France. In Cell, 2014
Here, we show that G2/M arrest results from untimely activation of the structure-specific endonuclease (SSE) regulator SLX4 complex (SLX4com) by Vpr, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex.
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Fan et al., Hangzhou, China. In Science, 2014
Oocyte-specific deletion of the CRL4 linker protein DDB1 or its substrate adaptor VPRBP (also known as DCAF1) caused rapid oocyte loss, premature ovarian insufficiency, and silencing of fertility maintaining genes.
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.
Parsons et al., Liverpool, United Kingdom. In Front Genet, 2013
For example, we have shown that the E3 ubiquitin ligase Mule, the tumor suppressor protein ARF, and the deubiquitylation enzyme USP47 modulate DNA repair by controlling cellular levels of DNA polymerase β, and also that polynucleotide kinase phosphatase levels are controlled by ATM-dependant phosphorylation and Cul4A-DDB1-STRAP-dependent ubiquitylation.
The role of Cockayne syndrome group A (CSA) protein in transcription-coupled nucleotide excision repair.
Saijo, Suita, Japan. In Mech Ageing Dev, 2013
A protein complex consisting of CSA, DDB1, cullin 4A, and Roc1 exhibits ubiquitin ligase activity.
Transcription directed by human core promoters with a HomolD box sequence requires DDB1, RECQL and RNA polymerase II machinery.
Maldonado et al., Santiago, Chile. In Gene, 2012
The data suggested that HomolD-containing promoters require the RNA polymerase II machinery and the proteins DDB1 and RECQL for accurate transcription.
Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication.
Slagle et al., Houston, United States. In Virology, 2012
Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication.
Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Cockayne syndrome protein A in complex with DNA damage-binding protein 1.
Pannu et al., Leiden, Netherlands. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystals of CSA-DDB1 had unit-cell parameters a = b = 142.03, c = 250.19 A and diffracted to 2.9 A resolution on beamline ID14-1
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Thomä et al., Basel, Switzerland. In Febs Lett, 2011
Studies indicate the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 in DNA repair of UV-induced DNA lesions.
Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells.
Hengel et al., Düsseldorf, Germany. In Plos Pathog, 2011
In a constructive process, pM27 recruits DDB1 to exploit ubiquitin ligase complexes catalyzing the obstruction of the STAT2-dependent antiviral state of cells to permit viral replication.
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