Iron and oxygen sensing: a tale of 2 interacting elements?
London, United Kingdom. In Metallomics, Feb 2015
In terms of responses to iron HIF2α is of major importance in key tissues such as the intestine where several iron transporters (Ferroportin, Dcytb) contain HREs within their promoters which bind HIF2α.
Ascorbic acid--important for iron metabolism.
Sofia, Bulgaria. In Folia Med (plovdiv), 2008
The increase of plasma ascorbate in human iron deficiency, especially in females in active age, could explain gender-related biological variation of plasma levels of vitamin C. The possible participation of ferric reductase activity Dcytb in transferrin cycle in liver and in neutrophil host defense implies new aspects of the role of vitamin C in the regulation of iron homeostasis.
Structure/function overview of proteins involved in iron storage and transport.
London, United Kingdom. In Curr Med Chem, 2004
We review our current understanding of the intestinal absorption of iron in the light of recently identified membrane proteins, namely the ferrric reductase, Dcytb, the two iron(II) transport proteins, DMT1 and ferroportin/Ireg1, and hephaestin, the membrane-bound homologue of the ferroxidase ceruloplasmin.