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Tumor necrosis factor receptor superfamily, member 6b, decoy

DcR3, decoy receptor 3, TR6
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Fas Ligand, CAN, V1a, HAD, PrP
Papers using DcR3 antibodies
Transgenic Expression of Decoy Receptor 3 Protects Islets from Spontaneous and Chemical-induced Autoimmune Destruction in Nonobese Diabetic Mice
Supplier
Sytwu Huey-Kang et al., In The Journal of Experimental Medicine, 2002
... DCR3 signals in PD7 and PD8 founders and provided the relative copy number of each transgenic line, indicated by the ...
Papers on DcR3
The anti-inflammatory effect of TR6 on LPS-induced mastitis in mice.
New
Zhang et al., Changchun, China. In Int Immunopharmacol, Jan 2016
In this study, we synthesized a TRIAP-derived decoy peptide (TR6) containing, the N-terminal portion of the third helical region of the [TIRAP] TIR domain (sequence "N"-RQIKIWFQNRRMKWK and -KPGFLRDPWCKYQML-"C").
Utility of immune response-derived biomarkers in the differential diagnosis of inflammatory disorders.
Review
New
Kullberg et al., Nijmegen, Netherlands. In J Infect, Jan 2016
CD64 expression on neutrophils can discriminate between non-infectious systemic inflammation and sepsis, and limited evidence suggests the same for decoy receptor 3. PCT is useful for both diagnosing bacterial infection complicating influenza and guiding antibiotic treatment in lower respiratory tract infections in general.
Usefulness of Circulating Decoy Receptor 3 in Predicting Coronary Artery Disease Severity and Future Major Adverse Cardiovascular Events in Patients With Multivessel Coronary Artery Disease.
New
Lin et al., Taipei, Taiwan. In Am J Cardiol, Nov 2015
Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, is an antiapoptotic soluble receptor considered to play an important role in immune modulation and has pro-inflammatory functions.
Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation.
Review
New
Bamias et al., Athens, Greece. In Inflamm Bowel Dis, Oct 2015
Decoy receptor 3 (DcR3) competes with DR3 for TL1A binding and inhibits functional signaling.
Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts.
New
Kurosaka et al., Kōbe, Japan. In Mol Med Report, Oct 2015
Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which is the rate‑limiting enzyme in serotonin synthesis.
[Cell death in malignant tumors : Relevance of cell death regulation for metastasis].
New
Roth, Heidelberg, Germany. In Pathologe, Oct 2015
As an example, the decoy receptor 3 protein (DcR3) functions both as an anti-apoptotic protein and as a direct promotor of invasion and migration of tumor cells.
Pseudoxanthomonas sangjuensis sp. nov., isolated from greenhouse soil.
New
Kwon et al., South Korea. In Int J Syst Evol Microbiol, Sep 2015
Pseudoxanthomonas daejeonensis TR6-08(T) (96.7%) and Pseudoxanthomonas kalamensis JA40(T) (96.7%).
The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases.
Review
New
Bamias et al., Athens, Greece. In Semin Arthritis Rheum, Aug 2015
IMPORTANCE: TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively.
Decoy Receptor 3 Improves Survival in Experimental Sepsis by Suppressing the Inflammatory Response and Lymphocyte Apoptosis.
Chen et al., Shanghai, China. In Plos One, 2014
Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, is an anti-inflammatory and anti-apoptotic factor.
Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection.
Tarng et al., Taipei, Taiwan. In Sci Rep, 2014
Decoy receptor 3 (DcR3) expression in kidneys has been shown to predict progression of chronic kidney disease.
Promotive Effects of Dcr3 Gene on the Occurrence and Progression of Gastric Cancer and its Mechanism.
Wang et al., In Hepatogastroenterology, 2014
BACKGROUND/AIMS: To observe the effects of DcR3 gene on the occurrence and progression of gastric cancer and explore its mechanism.
The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation.
Review
Cominelli et al., Cleveland, United States. In Curr Opin Gastroenterol, 2013
The decoy receptor 3 (DcR3) competes for TL1A binding and inhibits functional signaling.
The role of TL1A and DR3 in autoimmune and inflammatory diseases.
Review
Nakamura et al., Ōmura, Japan. In Mediators Inflamm, 2012
TNF-like ligand 1A (TL1A), which binds its cognate receptor DR3 and the decoy receptor DcR3, is an identified member of the TNF superfamily.
Decoy receptor 3 suppresses TLR2-mediated B cell activation by targeting NF-κB.
GeneRIF
Leu et al., Taipei, Taiwan. In J Immunol, 2012
These results imply that DcR3 may regulate B cell activation by suppressing the activation of NF-kappaB.
Decoy receptor 3 enhances tumor progression via induction of tumor-associated macrophages.
GeneRIF
Hsieh et al., Taipei, Taiwan. In J Immunol, 2012
Significantly enhanced tumor growth and spreading are observed in DcR3-transgenic mice; DcR3-transfectant cells grow faster and result in infiltration by tumor-associated macrophages.
Overexpression of decoy receptor 3 in synovial tissues of inflammatory arthritis.
GeneRIF
Chou et al., Taipei, Taiwan. In Clin Exp Rheumatol, 2012
The increased synovial inflammatory cells infiltration in rheumatoid arthritis and ankylosing spondylitis was associated with the elevated DCR3 expression.
Decoy receptor 3 attenuates collagen-induced arthritis by modulating T cell activation and B cell expansion.
GeneRIF
Chang et al., Taipei, Taiwan. In J Rheumatol, 2011
Data suggest that that the protective effects of decoy receptor 3 in collagen-induced arthritis resulted from modulation of the immune system by maintaining the B/T cell balance and decreasing lymphocyte expansion.
Clinical significance of expression and amplification of the DcR3 gene in pancreatic carcinomas.
GeneRIF
Zheng et al., China. In Asian Pac J Cancer Prev, 2011
High expression and amplification of the DcR3 gene is associated with pancreatic carcinoma.
TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.
Impact
Wei et al., Rockville, United States. In Immunity, 2002
Here we show that an endothelial cell-derived TNF-like factor, TL1A, is a ligand for DR3 and decoy receptor TR6/DcR3 and that its expression is inducible by TNF and IL-1alpha.
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer.
Impact
Ashkenazi et al., San Francisco, United States. In Nature, 1999
Here we report the discovery of a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds to FasL and inhibits FasL-induced apoptosis.
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