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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

DCP1 Dcp1p

Dcp1, Dcp1p
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002 [PubMed 12417715]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: caspase-3, Dcp2, PrP, CAN, Angiotensin II
Papers on Dcp1
The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila.
Tsujimura et al., Fuchū, Japan. In Dev Biol, Sep 2015
We analyzed the role of effector caspases drICE and dcp-1 in optic lobe cell death and subsequent corpse clearance using mutants.
The BEACH Domain Protein SPIRRIG Is Essential for Arabidopsis Salt Stress Tolerance and Functions as a Regulator of Transcript Stabilization and Localization.
Hülskamp et al., Köln, Germany. In Plos Biol, Jul 2015
We show that SPI interacts with the P-body core component DECAPPING PROTEIN 1 (DCP1), associates to mRNA processing bodies (P-bodies), and regulates their assembly upon salt stress.
Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection.
Fearns et al., Boston, United States. In Virology, Jul 2015
We investigated the effect of RSV infection on the expression patterns of cellular proteins involved in regulating mRNA translation and degradation, and found that a processing-body protein involved in mRNA degradation, decapping protein 1a (DCP1), was phosphorylated rapidly following infection.
Role of cytoplasmic deadenylation and mRNA decay factors in yeast apoptosis.
N M et al., Hyderābād, India. In Fems Yeast Res, Mar 2015
Strains of Saccharomyces cerevisiae lacking factors involved in 5' to 3' mRNA decay pathway (DCP1, DCP2, DHH1, PAT1, LSM1 and LSM4) exhibit caspase-dependent apoptosis and accelerated chronological aging.
Diffuse decapping enzyme DCP2 accumulates in DCP1 foci under heat stress in Arabidopsis thaliana.
Watanabe et al., Tokyo, Japan. In Plant Cell Physiol, 2015
The decapping enzymes DCP1 and DCP2 are components of a decapping complex that degrades mRNAs.
The role of disordered protein regions in the assembly of decapping complexes and RNP granules.
Izaurralde et al., Tübingen, Germany. In Genes Dev, 2014
DCP2 catalytic activity is stimulated by DCP1, and these proteins form the conserved core of the decapping complex.
From an ACE polymorphism to genome-wide searches for eQTL.
Soubrier, Paris, France. In J Clin Invest, 2013
Angiotensin I-converting enzyme (ACE, or DCP1) is a zinc metallopeptidase that converts angiotensin I into the vasoactive and aldosterone-stimulating peptide angiotensin II and cleaves bradykinin into inactive peptides.
Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation.
Chua et al., New York City, United States. In Embo J, 2012
These results suggest that mRNA decapping through MPK6-DCP1-DCP5 pathway serves as a rapid response to dehydration stress in Arabidopsis.
The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
Sprangers et al., Tübingen, Germany. In Embo J, 2012
Edc3 & Scd6 stimulate decapping in vitro, presumably by preventing the Dcp1:Dcp2 complex from adopting an inactive conformation. Protein interactions via LSm & HLM domains were identified.
Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition.
Gross et al., San Francisco, United States. In Rna, 2011
Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition
Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.
Park et al., Knoxville, United States. In J Comp Neurol, 2011
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes.
Yoo et al., Taejŏn, South Korea. In Bmc Cell Biol, 2009
Autophagy suppresses Dcp-1-mediated apoptotic cell death, whereas Dcp-1 positively regulates autophagy, possibly through feedback regulation.
Mammalian stress granules and processing bodies.
Anderson et al., Boston, United States. In Methods Enzymol, 2006
PBs are associated with mRNA decay and contain the decapping enzymes DCP1/2, the 5' to 3' exonuclease Xrn1, the Lsm proteins (1-7), and the scaffolding proteins hedls/GE-1 and GW182.
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.
Meier et al., London, United Kingdom. In Nat Cell Biol, 2005
The importance of IBM-mediated regulation of effector-caspases in vivo is substantiated by the enhanced apoptotic potency of IBM-mutant versions of drICE, DCP-1 and caspase-7.
Regulation of mRNA decay: decapping goes solo.
Jacobson, Worcester, United States. In Mol Cell, 2004
Subsequent recruitment of Dcp1p/Dcp2p to the complex appears to ensure rapid, deadenylation-independent decapping of the mRNA.
Sequence variation in the human angiotensin converting enzyme.
Nickerson et al., Seattle, United States. In Nat Genet, 1999
Angiotensin converting enzyme (encoded by the gene DCP1, also known as ACE) catalyses the conversion of angiotensin I to the physiologically active peptide angiotensin II, which controls fluid-electrolyte balance and systemic blood pressure.
Requirement for DCP-1 caspase during Drosophila oogenesis.
Steller et al., Cambridge, United States. In Science, 1998
Loss of function for the dcp-1 gene, which encodes a caspase, caused female sterility by inhibiting this transfer.
DCP-1, a Drosophila cell death protease essential for development.
Steller et al., Cambridge, United States. In Science, 1997
A Drosophila caspase, named Drosophila caspase-1 (DCP-1), was identified and found to be structurally and biochemically similar to Caenorhabditis elegans CED-3.
An essential component of the decapping enzyme required for normal rates of mRNA turnover.
Parker et al., Tucson, United States. In Nature, 1996
We have identified a yeast gene, termed DCP1, that encodes the decapping enzyme, or an essential component of a decapping complex.
Essential Surgery: Key Messages of This Volume
Debas et al., Washington, D.C., United States. In Unknown Journal, 0001
Economic evaluations of cataract surgery found the procedure to be cost-effective, even under resource-constrained circumstances; Javitt pioneered cost-effectiveness analysis (CEA) for surgery, including his chapter on cataract in Disease Control Priorities, first edition (DCP1) in 1993 (Javitt 1993).
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