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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

DCL1 endoribonuclease Dicer

Encodes a Dicer homolog. Dicer is a RNA helicase involved in microRNA processing. Mutations in this locus can result in embryo lethality. Embryo shape at seed maturity is globular-elongate. Other mutants convert the floral meristems to an indeterminate state, others yet show defects in ovule development. mRNA is expressed in all shoot tissues. DCL1 is able to produce miRNAs and siRNAs. (from NCBI)
Top mentioned proteins: Dicer, Cdc4, prolactin receptor, CAN, POLYMERASE
Papers on DCL1
(1)H, (13)C and (15)N resonance assignments of human DCL-1 (CD302) extracellular domain.
Chmelík et al., Praha, Czech Republic. In Biomol Nmr Assign, Feb 2016
UNASSIGNED: DCL-1 (CD302) is a single-pass type one transmembrane protein which is predominantly expressed on myeloid cell lines.
microRNA Maturation and microRNA Target Gene Expression Regulation Are Severely Disrupted in Soybean dicer-like1 Double Mutants.
Stupar et al., Newcastle, South Africa. In G3 (bethesda), Jan 2016
In plants, DICER-LIKE1 (DCL1) is the founding member of a highly conserved family of RNase III-like endonucleases that function as core machinery proteins to process hairpin-like precursor transcripts into mature miRNAs, small regulatory RNAs, 21 to 22 nucleotides in length.
Plants Encode a General siRNA Suppressor That Is Induced and Suppressed by Viruses.
Vaucheret et al., Versailles, France. In Plos Biol, Dec 2015
In plants, the RNaseIII enzyme DICER-LIKE1 (DCL1) produces miRNAs, whereas DCL2, DCL3, and DCL4 produce various size classes of siRNAs.
Analysis of the Maize dicer-like1 Mutant, fuzzy tassel, Implicates MicroRNAs in Anther Maturation and Dehiscence.
Thompson et al., Greenville, United States. In Plos One, Dec 2015
The maize fuzzy tassel (fzt) mutant has a mutation in dicer-like1 (dcl1), which encodes a key enzyme required for microRNA (miRNA) biogenesis.
New insights into pri-miRNA processing and accumulation in plants.
Yu et al., Lincoln, United States. In Wiley Interdiscip Rev Rna, Sep 2015
They are processed from their primary transcripts called primary miRNA transcripts (pri-miRNAs) by the processor complex containing the RNAse III enzyme, DICER-LIKE1 (DCL1), in plants.
microRNA biogenesis, degradation and activity in plants.
Yu et al., Lincoln, United States. In Cell Mol Life Sci, 2015
After excised from primary miRNA transcript by dicer-like1 (DCL1, an RNAse III enzyme), miRNAs bind and guide their effector protein named argonaute 1 (AGO1) to silence the expression of target RNAs containing their complementary sequences in plants.
Chimeric DCL1-Partnering Proteins Provide Insights into the MicroRNA Pathway.
Waterhouse et al., Sydney, Australia. In Front Plant Sci, 2014
In Arabidopsis thaliana, efficient microRNA (miRNA) production requires DICER-LIKE1 (DCL1) with the assistance of a partnering protein, DOUBLE-STRANDED RNA BINDING1 (DRB1) or DRB2.
miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis.
Martienssen et al., New York City, United States. In Nature, 2014
In plants, post-transcriptional gene silencing (PTGS) is mediated by DICER-LIKE 1 (DCL1)-dependent microRNAs (miRNAs), which also trigger 21-nucleotide secondary short interfering RNAs (siRNAs) via RNA-DEPENDENT RNA POLYMERASE 6 (RDR6), DCL4 and ARGONAUTE 1 (AGO1), whereas transcriptional gene silencing (TGS) of transposons is mediated by 24-nucleotide heterochromatic (het)siRNAs, RDR2, DCL3 and AGO4 (ref.
Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways.
Jin et al., Riverside, United States. In Science, 2013
The Arabidopsis ago1 mutant exhibits reduced susceptibility to B. cinerea, and the B. cinerea dcl1 dcl2 double mutant that can no longer produce these Bc-sRNAs displays reduced pathogenicity on Arabidopsis and tomato.
Biogenesis, turnover, and mode of action of plant microRNAs.
Chen et al., Riverside, United States. In Plant Cell, 2013
Mature miRNAs are processed from primary miRNA transcripts by the endonuclease activity of the DICER-LIKE1 (DCL1) protein complex.
Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1.
Weigel et al., Tübingen, Germany. In Cell, 2012
As in animals, the core microprocessor in plants is a Dicer protein, DICER-LIKE1 (DCL1).
The helicase and RNaseIIIa domains of Arabidopsis Dicer-Like1 modulate catalytic parameters during microRNA biogenesis.
Fedoroff et al., United States. In Plant Physiol, 2012
The DCL1 helicase domain attenuates cleavage activity and is required for the accurate processing of primary miRNA.
MicroRNAs prevent precocious gene expression and enable pattern formation during plant embryogenesis.
Bartel et al., Cambridge, United States. In Genes Dev, 2011
DCL1 is required for cell differentiation events as early as the eight-cell stage and soon thereafter for proper division of the hypophysis and subprotoderm cells
DLC1 negatively regulates angiogenesis in a paracrine fashion.
Lo et al., Sacramento, United States. In Cancer Res, 2010
Decreased DCL1 is associated with angiogenesis in prostate cancer.
Global effects of the small RNA biogenesis machinery on the Arabidopsis thaliana transcriptome.
Weigel et al., Tübingen, Germany. In Proc Natl Acad Sci U S A, 2010
DCL1 is not only involved in miRNA action but also contributes to silencing of a subset of transposons, apparently through an effect on DNA methylation.
Expression of microRNAs and its regulation in plants.
Ruan et al., Lubbock, United States. In Semin Cell Dev Biol, 2010
Expression of miRNAs in plants involves transcription from MIRNA loci by RNA polymerase II (pol II), multi-step processing of the primary transcripts by the DICER-LIKE1 (DCL1) complex, and formation of effector complexes consisting of mature miRNAs and ARGONAUTE (AGO) family proteins.
RNAi-mediated down-regulation of DCL1 and AGO1 induces developmental changes in resynthesized Arabidopsis allotetraploids.
Chen et al., Austin, United States. In New Phytol, 2010
RNA interference of DCL1 and AGO1 led to dominant negative phenotypes and decreased accumulation of several small rna tested in the transgenic resynthesized allotetraploids.
C-type lectins and phagocytosis.
Brown et al., Cape Town, South Africa. In Immunobiology, 2008
Here, we review the phagocytic roles of the mannose receptor, Dectin-1, dendritic cell-specific ICAM grabbing non-integrin (DC-SIGN), DCL-1, mannose binding lectin and surfactant proteins A and D.
Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning.
Jacobsen et al., Los Angeles, United States. In Nat Genet, 2006
Here, we study the role of the four Arabidopsis thaliana DICER-LIKE genes (DCL1-DCL4) in these processes.
Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis.
Zhu et al., Riverside, United States. In Cell, 2006
Initial cleavage of the P5CDH transcript guided by the 24-nt siRNA establishes a phase for the subsequent generation of 21-nt siRNAs by DCL1 and further cleavage of P5CDH transcripts.
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