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Defective in sister chromatid cohesion 1 homolog

DCC1, DCCI
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009] (from NCBI)
Top mentioned proteins: Ctf18, CAN, cardiotrophin-1, Boc, STEP
Papers on DCC1
Alcohol-induced ciliary dysfunction targets the outer dynein arm.
New
Wirschell et al., Atlanta, United States. In Am J Physiol Lung Cell Mol Physiol, Apr 2015
Furthermore, using a phospho-threonine-specific antibody, we determined that the phosphorylation state of DCC1 of the outer dynein arm-docking complex is altered in the presence of alcohol, and its phosphorylation correlates with AICD.
The development of a new analytical model for the identification of saccharide binders in paint samples.
Bonaduce et al., Pisa, Italy. In Plos One, 2011
Our research was carried out independently at two different laboratories: the Getty Conservation Institute in Los Angeles, USA (GCI) and the Department of Chemistry and Industrial Chemistry of the University of Pisa, Italy (DCCI).
Analysis of plant gums and saccharide materials in paint samples: comparison of GC-MS analytical procedures and databases.
Bonaduce et al., Pisa, Italy. In Chem Cent J, 2011
The procedures have been developed, optimised and systematically used to characterise plant gums at the Getty Conservation Institute in Los Angeles, USA (GCI) and the Department of Chemistry and Industrial Chemistry of the University of Pisa, Italy (DCCI).
Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8.
GeneRIF
Tsurimoto et al., Fukuoka, Japan. In J Biol Chem, 2010
Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8.
Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target.
Hieter et al., Vancouver, Canada. In Mol Biol Cell, 2009
The genetic interactions tested are highly conserved between S. cerevisiae and C. elegans and suggest that the alternative RFC components DCC1, CTF8, and CTF18 are ideal therapeutic targets because of their mild phenotype when knocked down singly in C. elegans.
Familial adenomatous polyposis: analysis of genetic instability of microsatellites Loci and genetic alternations of tumor suppressor genes.
Komel et al., Tuzla, Bosnia and Herzegovina. In Bosn J Basic Med Sci, 2008
Genetic alteration of tumor suppressor gene APC appeared at 4 samples, p53 at 3 samples, RB1 at 2 samples and NM23 only at 1 sample, but tumor suppressor genes DCC1 and DCC2 were homozygote.
Single-gene deletions that restore mating competence to diploid yeast.
Kennedy et al., Seattle, United States. In Fems Yeast Res, 2008
Three of these, lacking CTF8, CTF18, and DCC1, mate at a low frequency with either MATa or MATalpha haploids.
Genetic dissection of parallel sister-chromatid cohesion pathways.
Brown et al., Toronto, Canada. In Genetics, 2007
These data defined two cohesion pathways, one containing CSM3, TOF1, CTF4, and CHL1, and the second containing MRC1, CTF18, CTF8, and DCC1.
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer.
Caldas et al., Cambridge, United Kingdom. In Genome Biol, 2006
(THRAP6, DCC1, SQLE, SPG8) and 11q14.1 (NDUFC2, ALG8, USP35) associated with significantly worse prognosis.
X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivity.
Baccari et al., Berkeley, United States. In Genetics, 2005
We present data for deletion mutants involving the genes DOT1, MDM20, NAT3, SPT7, SPT20, GCN5, HFI1, DCC1, and VID21/EAF1 and discuss their potential roles in repair.
Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II.
Nasmyth et al., Vienna, Austria. In J Cell Sci, 2004
In budding yeast, a specialized replication factor C called RF-C(Ctf18/Dcc1/Ctf8) and the DNA-polymerase-alpha-associated protein Ctf4 are required to maintain sister-chromatid cohesion in cells arrested for long periods in mitosis.
The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.
GeneRIF
Hurwitz et al., New York City, United States. In Proc Natl Acad Sci U S A, 2003
The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.
Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.
GeneRIF
Chen et al., Rochester, United States. In J Biol Chem, 2003
hCTF18, hCTF8, and hDCC1 interact with each other as well as with the p38 subunit of RFC
Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.
Hieter et al., Baltimore, United States. In Mol Cell, 2001
We have identified and characterized an alternative RFC complex RFC(Ctf18p, Ctf8p, Dcc1p) that is required for sister chromatid cohesion and faithful chromosome transmission.
Partial purification of a receptor for the adipokinetic hormones from Musca autumnalis face flies.
Hayes et al., Beltsville, United States. In Prep Biochem, 1992
Partial purification of the receptors for the neurohormones, diptera corpora cardiaca factors 1 and 2 (DCC1 and DCC2) was achieved.
Subunit composition and Ca(2+)-ATPase activity of the vacuolar ATPase from barley roots.
Morrissey et al., Albany, United States. In Arch Biochem Biophys, 1992
The purified vacuolar ATPase was inhibited up to 90% by KNO3 or 80% by dicyclohexylcarbodiimide (DCCI).
Analogs of phalloidin. D-Abu2-Lys7-phalloin, an F-actin binding analog, its rhodamine conjugate (RLP) a novel fluorescent F-actin-probe, and D-Ala2-Leu7-phalloin, an inert peptide.
Seeliger et al., In Int J Pept Protein Res, 1983
The analogs [D-Abu2-Lys7]-phalloin (1) and [D-Ala2-Leu7]-phalloin (2) are obtained by cyclization of the monocyclic thioether peptides 5 and 7 with DCCI and diphenylphosphoro-azidate respectively.
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