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CD209 molecule

DC-SIGN, CD209
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, CD4, V1a, IL-10, CD45
Papers using DC-SIGN antibodies
Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever
Supplier
Guzik Krzysztof et al., In Journal of Biomedicine and Biotechnology, 2007
... CD16 (clone: DJ130c, DakoCytomation), CD11b (clone: ICRF44, Becton Dickinson and Co., Franklin Lakes, USA), and CD209 (clone: DCN46, Becton Dickinson) and subsequent flow cytometry ...
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
Supplier
Ratner Adam J., In PLoS ONE, 2002
... phenotype was evaluated by immunofluorescent staining for CD14 (DakoCytomation), CD16 (DakoCytomation), CD11b (Becton Dickinson), and CD209 (Becton Dickinson) of detached cells and ...
Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.
Supplier
Ng Fong Poh Lisa, In PLoS ONE, 2001
... and stained (anti-DC-SIGN antibody from BD Biosciences) to confirm expression of ...
Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.
Supplier
Hirayama Kenji, In PLoS Neglected Tropical Diseases, 2000
... Monoclonal Ab to TLR2 was kindly provided by Genentech, and mAb to mannose receptor and DC-SIGN were obtained from BD Biosciences.
Presence of HIV-1 in human parenchymal and non-parenchymal liver cells in vivo
Supplier
Carrington Mary et al., In The Journal of Experimental Medicine, 1992
... DC-SIGN mRNA) were determined by 5′ rapid amplification of cDNA ends (RACE; CLONTECH Laboratories, Inc.) ...
Papers on DC-SIGN
Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-κB.
New
Bufe et al., Bochum, Germany. In J Immunol, Feb 2016
In the search for a molecular mechanism, we found that AG binds to the immune modulatory receptors DC-specific ICAM-3 -: grabbing non integrin (DC-SIGN) and macrophage mannose receptor 1 (MMR-1).
Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells.
New
Wang et al., Shanghai, China. In J Virol, Jan 2016
Mast cells isolated from gut mucosal tissues were found to express a variety of HIV-1 attachment factors (HAFs) DC-SIGN, HSPG, α4β7 integrin, and mediated capture of HIV-1 on the cell surface.
Suppression of proatherogenic leukocyte interactions by MCS-18 - Impact on advanced atherosclerosis in ApoE-deficient mice.
New
Dietel et al., Nürnberg, Germany. In Atherosclerosis, Jan 2016
Compared to controls, CD209 (p < 0.001) and CCR7 (p = 0.003) expression was decreased in MCS-18-treated DCs, while in HUVECs lower levels of ICAM-1 (p < 0.001) and of phosphorylated NF-κB-p65 (p = 0.002) were observed.
Is fucose the answer to the immunomodulatory paradox of Quillaja saponins?
Review
New
Marciani, Lewisville, United States. In Int Immunopharmacol, Dec 2015
From structural and functional analogies with the helminths' fucosylated glycans, it is possible to infer that these saponins' Fucp must bind to the lectin DC-SIGN on dendritic cells (DC).
Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN.
New
Londrigan et al., Melbourne, Australia. In Sci Rep, Dec 2015
The C-type lectin receptors (CLRs) DC-SIGN (CD209) and L-SIGN (CD209L) enhance IAV infection however it is not known if they act as attachment factors, passing virions to other unknown receptors for virus entry, or as authentic entry receptors for CLR-mediated virus uptake and infection.
Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers.
Review
New
Kalinke et al., Hannover, Germany. In Eur J Pharm Biopharm, Sep 2015
Examples of CLR expressed by APCs include DEC-205 (CD205) expressed by myeloid dendritic cells (DC) and monocytes, the mannose receptor C type 1 (MR, CD206) expressed by DC, monocytes and macrophages, DC-SIGN (CD209) expressed by DC, and several others.
DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde.
New
Impact
van Kooyk et al., Amsterdam, Netherlands. In Immunity, Jul 2015
In this issue of Immunity, Conde et al. (2015) showed that a costimulatory blockade favors the accumulation of CD209a(+) macrophages which, upon interaction with fucosylated tissue ligands, promotes the expansion of CD4(+)Foxp3(+) Treg cell number.
DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.
New
Impact
Ochando et al., New York City, United States. In Immunity, Jul 2015
Here, we demonstrate that costimulatory blockade favored accumulation of DC-SIGN-expressing macrophages that inhibited CD8(+) T cell immunity and promoted CD4(+)Foxp3(+) Treg cell expansion in numbers.
PRRS virus receptors and their role for pathogenesis.
Review
New
Yoo et al., Urbana, United States. In Vet Microbiol, Jul 2015
At least six cellular molecules have been described so far as putative receptors for PRRSV, and they include heparan sulfate, vimentin, CD151, sialoadhesin (CD169; siglec-1), dendritic cell-specific intercellular adhesion melecule-3-grabbing non-integrin (DC-SIGN; CD209), and CD163 (SRCR, cysteine-rich scavenger receptor).
[Research on hepatitis C virus entry inhibitor].
Review
Zhu et al., In Bing Du Xue Bao, 2015
the process of HCV entering into host cell is the important step of drug intervention, in which HCV envelope protein El and E2, Host cell factors including Heparan sulfate(HS), CD81, scavenger receptor class B type I (SR-BI), Occludin (OCLD), Claudin (CLDN), low densitity lipoprotein receptor (LDLR), dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), Liver/lymph node specific ICAM-3-grabbing integrin(L-SIGN), trans- ferrin receptor 1 (TfR1) and so on play a important role.
Human lectins and their roles in viral infections.
Review
Tarr et al., Nottingham, United Kingdom. In Molecules, 2014
We focus on the structure, function and genetics of the well-characterised C-type lectin mannose-binding lectin, the ficolins, and the membrane-bound CD209 proteins expressed on dendritic cells.
The association between CD209 gene polymorphisms and pulmonary tuberculosis susceptibility: a meta-analysis.
Zhao et al., Wuhan, China. In Int J Clin Exp Pathol, 2014
AIM: Three common polymorphisms in CD209 gene (-336A/G, -871A/G and -139G/A) have been reportedly associated with pulmonary tuberculosis risk.
The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.
Impact
Coste et al., Toulouse, France. In Immunity, 2013
Here, we report that the macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors (CLRs) signature composed of Dectin-1, mannose receptor (MR), and the DC-SIGN homolog SIGNR3 expression.
DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.
GeneRIF
Ghebrehiwet et al., Stony Brook, United States. In Blood, 2012
C1q/gC1qR may regulate dendritic cells differentiation and function through the DC-SIGN-mediated induction of cell-signaling pathways.
Antibodies and carbohydrate ligands binding to DC-SIGN differentially modulate receptor trafficking.
GeneRIF
Figdor et al., Nijmegen, Netherlands. In Eur J Immunol, 2012
Prolonged exposure of dendritic cells to DC-SIGN Ab, but not carbohydrate ligands, resulted in reduced receptor expression levels, which lasted up to 2 days following removal of the Ab. Exposure to DC-SIGN Ab reduced the ability of the receptor to internalize.
Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and β2 integrins.
GeneRIF
Spetz et al., Huddinge, Sweden. In J Biol Chem, 2012
analysis of activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and beta2 integrins
Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.
GeneRIF
Jurado et al., Granada, Spain. In Plos One, 2011
Dectin-1 and DC-SIGN polymorphisms are associated with invasive pulmonary Aspergillosis infection
DC-SIGN (CD209) promoter -336 A/G (rs4804803) polymorphism associated with susceptibility of Kawasaki disease.
GeneRIF
Kuo et al., Kao-hsiung, Taiwan. In Scientificworldjournal, 2011
The G allele of DC-SIGN promoter -336 (rs4804803) is a risk allele in the development of KD.
Flt3 signaling-dependent dendritic cells protect against atherosclerosis.
Impact
Steinman et al., New York City, United States. In Immunity, 2011
DCs were of two types primarily: classical Flt3-Flt3L signaling-dependent, CD103(+)CD11b(-) DCs and macrophage-colony stimulating factor (M-CSF)-dependent, CD14(+)CD11b(+)DC-SIGN(+) monocyte-derived DCs.
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Impact
Ravetch et al., New York City, United States. In Nature, 2011
This anti-inflammatory activity of intravenous immunoglobulin is triggered by a minor population of IgG crystallizable fragments (Fcs), with glycans terminating in α2,6 sialic acids (sFc) that target myeloid regulatory cells expressing the lectin dendritic-cell-specific ICAM-3 grabbing non-integrin (DC-SIGN; also known as CD209).
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