High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Potential Modulation of Sirtuins by Oxidative Stress.
Montevideo, Uruguay. In Oxid Med Cell Longev, Dec 2015
In addition, oxidative stress can alter the interaction with other proteins, like SIRT1 with its protein inhibitor DBC1 resulting in a net increase of deacetylase activity.
Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows.
United Kingdom. In Animals (basel), 2014
These were predominantly associated with tissue turnover (e.g., BRINP1, FOXG1), immune function (e.g., IL17RB, CRISPLD2), inflammation (e.g., C3, SERPINF1, SERPINF2) and lipid metabolism (e.g., SCAP, ACBD5, SLC10A).
Molecular genesis of non-muscle-invasive urothelial carcinoma (NMIUC).
Charlottesville, United States. In Expert Rev Mol Med, 2009
The regions of chromosome 9 that harbour CDKN2A, CDKN2B, TSC1, PTCH1 and DBC1 are frequently mutated in NMIUC, resulting in functional loss; in addition, HRAS and FGFR3, which are both proto-oncogenes encoding components of the Ras-MAPK signalling pathway, have been found to harbour activating mutations in a large number of NMIUCs.