gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

Death-domain associated protein

Daxx, hDaxx
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: PML, CAN, RAD54, Histone, p53
Papers on Daxx
CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells.
Wong et al., Australia. In Nucleic Acids Res, 11 Apr 2015
Human ALT cancers show high mutation rates in ATRX and DAXX.
Silencing Daxx increases the anti-tumor activity of a TRAIL/shRNA Bcl-xL-expressing oncolytic adenovirus through enhanced viral replication and cellular arrest.
Song et al., Seoul, South Korea. In Cell Signal, 05 Apr 2015
Here, we show that Daxx downregulation increases the anti-tumorigenic activity through enhancement of viral replication and cellular arrest with combination of TRAIL/shBcl-xL-induced apoptosis.
Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid-Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder.
Benes et al., Boston, United States. In Jama Psychiatry, 04 Apr 2015
Methylation changes were enriched in MSX1, CCND2, and DAXX at specific loci within the hippocampus of patients with schizophrenia and bipolar disorder.
Heat shock protein 27 overexpression in CHO cells modulates apoptosis pathways and delays activation of caspases to improve recombinant monoclonal antibody titre in fed-batch bioreactors.
Ng et al., Singapore, Singapore. In Biotechnol J, 04 Apr 2015
Co-immunoprecipitation studies revealed HSP27 interactions with Akt, pro-Caspase 3 and Daxx and caspase activity profiling showed delayed increase in Caspase 2, 3, 8 and 9 activities.
CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells.
Dalal et al., Bethesda, United States. In Epigenetics Chromatin, Dec 2014
In such cells, we report that a subset of structurally distinct CENP-A-containing nucleosomes associate with canonical histone H3, and with the transcription-coupled chaperones ATRX and DAXX.
Integrated genomic characterization of adrenocortical carcinoma.
Bertherat et al., Paris, France. In Nat Genet, Jun 2014
We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we validated in an independent cohort of 77 ACCs.
Neuroendocrine tumors of the pancreas: current concepts and controversies.
Adsay et al., Atlanta, United States. In Endocr Pathol, Mar 2014
Loss of expression of DAXX and ATRX proteins has been recently identified in 45 %.
Molecular genetics of gliomas.
Brat et al., Atlanta, United States. In Cancer J, 2014
Pediatric GBMs have a distinctive molecular pathogenesis, as H3F3A and DAXX mutations are frequent, and their gene expression profile is different than adult GBMs.
Virion factors that target Daxx to overcome intrinsic immunity.
Wodrich et al., Hamburg, Germany. In J Virol, 2013
A number of recent reports suggest that several virion proteins may also play vital roles in gene activation processes, in particular by counteracting intrinsic immune mechanisms mediated by the PML nuclear body-associated cellular factors Daxx, ATRX, and Sp100.
Neuroendocrine tumours: cracking the epigenetic code.
Thirlwell et al., London, United Kingdom. In Endocr Relat Cancer, 2013
Recent progress has been facilitated by development of high-throughput tools including second-generation sequencing and arrays for analysis of the 'epigenome' of tumour and normal tissue, permitting unbiased approaches such as exome sequencing that identified mutations of chromatin-remodelling genes ATRX/DAXX in 44% of pancreatic NETs.
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Patel et al., New York City, United States. In Nature, 2012
DAXX is a metazoan histone chaperone specific to the evolutionarily conserved histone variant H3.3.
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors.
Matsukuma et al., Baltimore, United States. In Mod Pathol, 2012
These findings establish the existence of ATRX and DAXX defects and the alternative lengthening of telomeres phenotype in pancreatic neuroendocrine tumors in the context of MEN-1 syndrome
Interaction of dengue virus nonstructural protein 5 with Daxx modulates RANTES production.
Limjindaporn et al., Bangkok, Thailand. In Biochem Biophys Res Commun, 2012
This work demonstrates the interaction between DENV NS5 and Daxx and the role of the interaction on the modulation of RANTES production.
Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation.
Salomoni et al., London, United Kingdom. In Neuron, 2012
DAXX is associated with regulatory regions of selected activity-regulated genes, where it promotes H3.3 loading upon membrane depolarization. DAXX loss not only affects H3.3 deposition but also impairs transcriptional induction of these genes.
Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription.
Chung et al., Taipei, Taiwan. In J Biol Chem, 2012
Daxx, a HIPK kinase substrate in the apoptosis pathway, was phosphorylated by HIPK3 at Ser-669 in response to cAMP stimulation.
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Jabado et al., Montréal, Canada. In Nature, 2012
Mutations in ATRX (α-thalassaemia/mental retardation syndrome X-linked) and DAXX (death-domain associated protein), encoding two subunits of a chromatin remodelling complex required for H3.3 incorporation at pericentric heterochromatin and telomeres, were identified in 31% of samples overall, and in 100% of tumours harbouring a G34R or G34V H3.3 mutation.
Daxx interacts with and modulates the activity of CREB.
Shih et al., Taipei, Taiwan. In Cell Cycle, 2012
Depletion of endogenous Daxx by specific shRNA or overexpression of Daxx resulted in decreased or increased levels of the cAMP/PKA-induced reporter activity and target gene expression.
[Death domain-associated protein (DAXX)-mediated regulation of transcription and cell death].
Muromoto, Sapporo, Japan. In Yakugaku Zasshi, 2011
Death domain-associated protein (DAXX) is a multifunctional protein that modulates both cell death and transcription.
Altered telomeres in tumors with ATRX and DAXX mutations.
Meeker et al., Baltimore, United States. In Science, 2011
study found 61% of pancreatic neuroendocrine tumors had abnormal telomeres; all of the tumors with abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Papadopoulos et al., Baltimore, United States. In Science, 2011
identification of mutations in pancreatic neuroendocrine tumors; 44% had somatic inactivating mutations in MEN1; 43% had mutations in genes encoding DAXX and ATRX; clinically, mutations in MEN1 and DAXX/ATRX genes were associated with better prognosis
share on facebooktweetadd +1mail to friends