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Nuclear receptor subfamily 0, group B, member 1

DAX-1, NR0B1, Ahx
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SF-1, CAN, ACID, HAD, SRY
Papers using DAX-1 antibodies
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
Taylor Stephen S. et al., In The Journal of Cell Biology, 1997
... 10 μM peptide substrate (Biotinyl-Ahx-tetra (LRRWSLG); Bachem), 10 μM for Aurora ...
Papers on DAX-1
Novel renin inhibitors containing derivatives of N-alkylleucyl-β-hydroxy-γ-amino acids.
Sokulski et al., Warsaw, Poland. In J Pept Sci, Feb 2016
Three of these compounds contain isoamylamide of 6-aminohexanoic acid (ε-Ahx-Iaa) at the P2 '-P3 ' position.
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Shi et al., Nanning, China. In Reprod Domest Anim, Jan 2016
In comparison with controls, the mRNA expression level of pro-apoptosis factors (Fas, TNF, Cytochrome C, Apaf1, Chop, Caspase-3, Caspase-8, Caspase-9 and Caspase-12) and key genes in oestrogen receptor (ER) signalling pathway (ER α, ER β, Erk1/2, Hsp90 and DAX-1) were upregulated in the testes of the treatment groups.
Pilot Comparison of 68Ga-RM2 PET and 68Ga-PSMA PET in Patients with Biochemically Recurrent Prostate Cancer.
Iagaru et al., Stanford, United States. In J Nucl Med, Jan 2016
OBJECTIVES: Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA) is a positron emission tomography (PET) tracer that can detect prostate cancer relapses and metastases by binding to the extracellular domain of PSMA.
Interleukin 6 increases the in vitro expression of key proteins associated with steroidogenesis in the bovine adrenal zona fasciculata.
Judd et al., Provo, United States. In Domest Anim Endocrinol, Nov 2015
In contrast, IL-6 decreased in a concentration-dependent (P < 0.01 vs control for 1, 10, and 100 pg IL-6/mL) and time-dependent (P < 0.05 vs control for 30, 60,120, and 240 min of 10 pg IL-6/mL) manner the relative expression of the mRNA and protein for adrenal hypoplasia congenita-like protein (DAX-1), a nuclear factor that decreases expression of StAR and SEs.
DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease.
Achermann et al., London, United Kingdom. In Best Pract Res Clin Endocrinol Metab, Aug 2015
DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development.
[DAX1-unusual member of nuclear receptors superfamily with diverse functions].
Rubtsov et al., In Mol Biol (mosk), 2015
DAX1 protein is an unusual member of NR superfamily that does not have ligand and lacks typical DNA-binding domain.
Molecular cloning and characterization of amh and dax1 genes and their expression during sex inversion in rice-field eel Monopterus albus.
Li et al., Wuhan, China. In Sci Rep, 2014
The full-length cDNAs of amh and dax1 in the hermaphrodite, rice-field eel (Monopterus albus), were cloned and characterized in this study.
Orphan nuclear receptors as drug targets for the treatment of prostate and breast cancers.
Rennie et al., In Cancer Treat Rev, 2014
This review is a summary on ONRs that have been implicated in prostate and breast cancers, specifically retinoic acid-receptor-related orphan receptors (RORs), liver X receptors (LXRs), chicken ovalbumin upstream promoter transcription factors (COUP-TFs), estrogen related receptors (ERRs), nerve growth factor 1B-like receptors, and ‘‘dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1’’ (DAX1).
Swyer syndrome.
Conway et al., London, United Kingdom. In Curr Opin Endocrinol Diabetes Obes, 2014
In 46,XY gonadal dysgenesis, lack of testis development may be triggered by sex determining region Y, NR5A1, DHH or testis-determining gene loss-of-function mutations, DAX1 or WNT4 duplication or MAP3K1 gain-of-function mutations.
46,XX testicular disorder of sexual development with SRY-negative caused by some unidentified mechanisms: a case report and review of the literature.
Shi et al., Nanjing, China. In Bmc Urol, 2013
No mutation was detected in the coding region and exon/intron boundaries of the RSPO1, DAX1, SOX9, SOX3, SOX10, ROCK1, and DMRT genes, and no copy number variation in the whole genome sequence was found.
Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells.
Robson et al., Singapore, Singapore. In Stem Cells, 2013
Transcriptional differences between mouse embryonic and epiblast stem cells is mediated through a Sox2/Esrrb heterodimer regulating Nr0b1.
EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.
Lessnick et al., Salt Lake City, United States. In Cancer Genet, 2012
These data suggest that GGAA microsatellite polymorphisms in the NR0B1 gene might influence disease susceptibility and prognosis in Ewing sarcoma in unanticipated ways.
Characteristic induction of steroidogenic factor 1 (SF-1) and DAX-1 and enhanced expression of glucocorticoid synthesis-related genes in adrenals from spontaneously hypertensive rats.
Harikai, Nishinomiya, Japan. In Gen Physiol Biophys, 2012
These results suggest that the low level of DAX-1 may enhance the transcriptional activity of SF-1 and expression of genes related to glucocorticoid synthesis, which are targeted by SF-1, in adrenals from SHR.
Multiplex ligation-dependent probe amplification analysis of the NR0B1(DAX1) locus enables explanation of phenotypic differences in patients with X-linked congenital adrenal hypoplasia.
Riepe et al., Stockholm, Sweden. In Horm Res Paediatr, 2011
genetic association study in Swedish subjects: studies to characterize NR0B1 deletions (and contiguous gene deletions) in patients with X-linked congenital adrenal hypoplasia (and their mothers); correlation of genotypes with divergent phenotypes
The analysis of clinical manifestations and genetic mutations in Chinese boys with primary adrenal insufficiency.
Defen et al., Shanghai, China. In J Pediatr Endocrinol Metab, 2011
DAX1 gene mutations are associated with primary adrenal insufficiency.
Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family.
Melner et al., Québec, Canada. In Endocr Rev, 2005
Recent studies indicate that HSD3B2 gene regulation involves the orphan nuclear receptors steroidogenic factor-1 and dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome gene 1 (DAX-1).
Dax1 antagonizes Sry action in mammalian sex determination.
Lovell-Badge et al., London, United Kingdom. In Nature, 1998
DAX1, which encodes an unusual member of the nuclear hormone-receptor superfamily, is a gene that may be responsible for a sex-reversal syndrome in humans, referred to as dosage-sensitive sex reversal, in which XY individuals carrying duplications of Xp21, part of the small arm of the X chromosome, develop as females.
DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis.
Sassone-Corsi et al., Strasbourg, France. In Nature, 1997
Mutations in the DAX-1 gene are responsible for congenital X-linked adrenal hypoplasia, a disease that is associated with hypogonadotropic hypogonadism.
Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function.
Camerino et al., London, United Kingdom. In Nat Genet, 1996
An unusual member of the nuclear hormone receptor superfamily, DAX1, maps to the DSS critical region and is responsible for X-linked adrenal hypoplasia congenita.
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.
Rabl et al., Oxford, United Kingdom. In Nature, 1995
The DAX-1 (DSS-AHC critical region on the X, gene 1) gene was isolated and found to encode a new member of the nuclear hormone receptor family.
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