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Death associated protein 3

DAP3, death-associated protein 3
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: amylin, PrP, CAN, caspase-8, DR4
Papers on DAP3
Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics.
New
Liou et al., Singapore, Singapore. In J Biol Chem, Nov 2015
DAP3 is a mitochondrial ribosomal protein that involves in apoptosis, but its biological function has not been well characterized.
Triple-layer dissection of the lung adenocarcinoma transcriptome: regulation at the gene, transcript, and exon levels.
New
Chen et al., Yü-ching, Taiwan. In Oncotarget, Nov 2015
Genes selected by both detection methods include C16orf59, DAP3, ETV4, GABARAPL1, PPAR, RADIL, RSPO1, SERTM1, SRPK1, ST6GALNAC6, and TNXB.
Exosome release following activation of the dendritic cell immunoreceptor: a potential role in HIV-1 pathogenesis.
New
Gilbert et al., Québec, Canada. In Virology, Oct 2015
Unlike the EVs released from Raji-CD4-DCIR cells after antibody stimulation, those released from HIV-1-infected cells contain the pro-apoptotic protein DAP-3.
Effects of the knockdown of death-associated protein 3 expression on cell adhesion, growth and migration in breast cancer cells.
New
Mokbel et al., Peshāwar, Pakistan. In Oncol Rep, May 2015
The death-associated protein 3 (DAP3) is a highly conserved phosphoprotein involved in the regulation of autophagy.
The role of death-associated protein 3 in apoptosis, anoikis and human cancer.
Mokbel et al., London, United Kingdom. In Cancer Cell Int, 2014
Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis.
Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms.
AGIMM investigators et al., Reggio nell'Emilia, Italy. In Leukemia, 2014
Excluding the genes already described in MPN, for 8 genes (SCRIB, MIR662, BARD1, TCF12, FAT4, DAP3, POLG and NRAS), we demonstrated a mutation frequency between 3 and 8%.
Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy.
Jiang et al., Cardiff, United Kingdom. In Br J Cancer, 2014
BACKGROUND: DAP3 is a member of the death-associated protein (DAP) family and is characterised by proapoptotic function.
Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration.
Lu et al., Nanning, China. In Asian Pac J Cancer Prev, 2013
Three genes (DAP3, HSPB1 and CLDN) were independently confirmed by quantitative real-time PCR.
Diapause-associated protein3 functions as Cu/Zn superoxide dismutase in the Chinese oak silkworm (Antheraea pernyi).
Zhang et al., Hangzhou, China. In Plos One, 2013
pernyi), we cloned a novel diapause-associated protein 3 (DAP3) gene from A. pernyi by reverse transcription-polymerase chain reaction (RT-PCR) and studied the biological functions.
Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
Chen et al., United States. In J Med Chem, 2013
Replacement of the Dab-3 residue with a Dap-3 in combination with a relatively polar 6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonyl side chain as a fatty acyl replacement yielded analogue 5x, which demonstrated an improved in vitro antimicrobial and renal cytotoxicity profiles relative to polymyxin B (PMB).
Cypermethrin alters the expression profile of mRNAs in the adult rat striatum: a putative mechanism of postnatal pre-exposure followed by adulthood re-exposure-enhanced neurodegeneration.
Singh et al., Lucknow, India. In Neurotox Res, 2012
The expression patterns of V-akt murine thymoma viral oncogene homolog 1, B-cell lymphoma 2 (BCL-2), BCL-2-associated X protein, caspase 1, caspase 9, death-associated protein 3 and interleukin-1β were validated by the qRT-PCR.
The mRNA expression of DAP3 in human breast cancer: correlation with clinicopathological parameters.
GeneRIF
Mokbel et al., London, United Kingdom. In Anticancer Res, 2012
Study demonstrates an inverse association between DAP3 mRNA levels and tumour stage and clinical outcome in breast cancer.
Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
GeneRIF
Calakos et al., Durham, United States. In J Neurosci, 2011
The results of this study provide the first evidence for the mechanism by which the SAPAP family of scaffold proteins regulates AMPAR synaptic activity.
Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity.
GeneRIF
Calakos et al., Durham, United States. In J Neurosci, 2011
These results identify a role for SAPAP3 in the regulation of postsynaptic metabotropic glutamate receptors and endocannabinoid-mediated synaptic plasticity.
Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction.
GeneRIF
Miyazaki et al., Sapporo, Japan. In Apoptosis, 2010
identified a novel DAP3-binding protein termed death ligand signal enhancer (DELE); results demonstrated the biological significance of DELE for apoptosis signal mediated by death receptors
Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction.
GeneRIF
Miyazaki et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2010
DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77.
The mitochondrial death squad: hardened killers or innocent bystanders?
Review
Vaux et al., Australia. In Curr Opin Cell Biol, 2005
AIF, EndoG, ANT, cyclophilin D, Bit1, p53AIP, GRIM-19, DAP3, Nur77/TR3/NGFB-1, HtrA2/Omi and Smac/Diablo have all been convicted as killers, but new genetic technology is raising questions about their guilt.
Nuclear MRP genes and mitochondrial disease.
Review
Norman et al., Gainesville, United States. In Gene, 2005
One of the new proteins is a novel GTP binding protein, DAP3, that has been implicated in apoptosis.
A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins.
Impact
Reed et al., Los Angeles, United States. In Nat Immunol, 2001
We have found that the GTP-binding protein DAP3 binds directly (with high affinity) to the death domain of TNF-related apoptosis-inducing ligand (TRAIL) receptors, and is required for TRAIL-induced apoptosis.
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.
Review
Kimchi et al., Israel. In Oncogene, 1999
The list comprises a novel type of calcium/calmodulin-regulated kinase which carries ankyrin repeats and a death domain (DAP-kinase), a nucleotide-binding protein (DAP-3), a small proline-rich cytoplasmic protein (DAP-1), and a novel homolog of the eIF4G translation initiation factor (DAP-5).
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