A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.
Oklahoma City, United States. In Clin Rev Allergy Immunol, Dec 2015
Receptor activator for NF-κB ligand (RANKL or TNFSF11), a tumor necrosis factor (TNF) superfamily member, is the master cytokine required for osteoclastogenesis with essential co-stimulatory signals mediated by immunoreceptor tyrosine-based activation motif (ITAM)-signaling adaptors, DNAX-associated protein 12 kDa size (DAP12) and FcεRI gamma chain (FcRγ).
NKG2D Receptor and Its Ligands in Host Defense.
San Francisco, United States. In Cancer Immunol Res, Jun 2015
In humans, NKG2D transmits signals by its association with the DAP10 adapter subunit, and in mice alternatively spliced isoforms transmit signals either using DAP10 or DAP12 adapter subunits.
TREM2 in CNS homeostasis and neurodegenerative disease.
Jacksonville, United States. In Mol Neurodegener, 2014
The innate immune receptor and its adaptor protein—triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12)—possess the ability to modulate critical cellular functions via crosstalk with diverse signaling pathways.
Siglecs and immune regulation.
Boston, United States. In Annu Rev Immunol, 2011
This family also includes molecules involved in adhesion and phagocytosis and receptors that can associate with the ITAM-containing DAP12 adaptor.