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Hematopoietic cell signal transducer

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NKG2D, DAP12, CAN, MHC, V1a
Papers on DAP10
Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma.
Konjević et al., Belgrade, Serbia. In J Clin Pathol, Nov 2015
METHODS: Peripheral blood mononuclear cells (PBMCs) of 36 MMs and 28 HCs were analysed for the level of perforin, interferon-regulating transcription factor-1 (IRF-1), DAP10 and Src homology 2 domain-containing tyrosine phosphatase-1 by reverse transcriptase PCR, level of phosphorylated signal transducers and activators of transcription (pSTAT)-1, pSTAT-4, pSTAT-5 by western blot and interferon (IFN)-γ production by ELISA.
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Barrow et al., Cambridge, United Kingdom. In J Immunol, Nov 2015
TARM1 associated with the ITAM adaptor FcRγ but not with DAP10 or DAP12.
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice.
Bramson et al., Hamilton, Canada. In Mol Ther, Oct 2015
To enhance the CAR surface expression, we also engineered T cells to coexpress DAP10.
Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.
Shibuya et al., Tsukuba, Japan. In J Biol Chem, Oct 2015
CD300H has a short cytoplasmic tail and associates with the signaling adaptor proteins, DAP12 and DAP10.
NKG2D Receptor and Its Ligands in Host Defense.
Lanier, San Francisco, United States. In Cancer Immunol Res, Jun 2015
In humans, NKG2D transmits signals by its association with the DAP10 adapter subunit, and in mice alternatively spliced isoforms transmit signals either using DAP10 or DAP12 adapter subunits.
Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms.
Kuivaniemi et al., Berlin, Germany. In Int J Mol Sci, 2014
We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies.
Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells.
Paolini et al., Roma, Italy. In Sci Signal, 2014
Cytotoxic lymphocytes share the presence of the activating receptor NK receptor group 2, member D (NKG2D) and the signaling-competent adaptor DNAX-activating protein 10 (DAP10), which together play an important role in antitumor immune surveillance.
Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Dissen et al., Oslo, Norway. In J Immunol, 2012
Both adaptor proteins DAP12 and DAP10 can associate with rat CD94/NKG2C; rat CD94 coimmunoprecipitates with both DAP12 and DAP10.
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.
Wei et al., Hefei, China. In Plos Pathog, 2011
TGF-beta1 may reduce the expression of NKG2D/DAP10 and 2B4/SAPin patients with hepatitis B.
Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.
Coligan et al., Rockville, United States. In Blood, 2011
Other gamma(c) cytokines act similarly to IL-2 in up-regulating DAP10 expression and NKG2D-DAP10 surface expression.
HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway.
Zhang et al., Jinan, China. In Cell Mol Immunol, 2011
HMBOX1 negatively regulates the expression of NKG2D and the activation of the NKG2D/DAP10 signaling pathway in NK cells.
A possible mechanism of impaired NK cytotoxicity in cancer patients: down-regulation of DAP10 by TGF-beta1.
Heo et al., Seoul, South Korea. In Tumori, 2011
TGF-BETA1 down-modulates surface NKG2D expression by controlling the transcriptional and translational levels of DAP10.
The structural basis for intramembrane assembly of an activating immunoreceptor complex.
Chou et al., Boston, United States. In Nat Immunol, 2010
Functional mutagenesis demonstrated that similar polar intramembrane motifs are also important for assembly of the NK cell-activating NKG2D-DAP10 complex and the T cell antigen receptor (TCR)-invariant signaling protein CD3 complex.
DAP10- and DAP12-associated receptors in innate immunity.
Lanier, San Francisco, United States. In Immunol Rev, 2009
improved rejection of B16 melanomas in DAP10-deficient mice
Up on the tightrope: natural killer cell activation and inhibition.
Lanier, San Francisco, United States. In Nat Immunol, 2008
Here I highlight recent advances in our understanding of the structural properties and signaling pathways of the inhibitory and activating NK cell receptors, with a particular focus on the ITAM-dependent activating receptors, the NKG2D-DAP10 receptor complexes and the CD244 receptor system.
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway.
Medzhitov et al., New Haven, United States. In Nat Immunol, 2007
Here we developed a mouse model in which a fusion of the signaling adaptor DAP10 and ubiquitin efficiently downregulated expression of the activating receptor NKG2D on the surfaces of natural killer cells.
Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity.
Phillips et al., Palo Alto, United States. In Immunol Rev, 2006
Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.
Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse.
Colonna et al., Saint Louis, United States. In Immunol Rev, 2006
Activation signals are transmitted by adhesion-dependent pathways, immunoreceptor tyrosine-based activation motif (ITAM)-dependent pathways, DAP10 ITAM-independent pathways, and by signaling through immunoreceptor tyrosine-based switch motifs.
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
Leibson et al., Rochester, United States. In Nat Immunol, 2006
Human natural killer cells express NKG2D and require the transmembrane adaptor DAP10 to initiate their full cytotoxic activation.
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity.
Housseau et al., Baltimore, United States. In Nat Med, 2006
Their cytolytic capacity subsequently diminishes, associated with the loss of NKG2D receptor (also known as Klrk1) and its adaptors, Dap10 and Dap12.
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