NKG2D Receptor and Its Ligands in Host Defense.
San Francisco, United States. In Cancer Immunol Res, Jun 2015
In humans, NKG2D transmits signals by its association with the DAP10 adapter subunit, and in mice alternatively spliced isoforms transmit signals either using DAP10 or DAP12 adapter subunits.
Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms.
Berlin, Germany. In Int J Mol Sci, 2014
We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies.
Up on the tightrope: natural killer cell activation and inhibition.
San Francisco, United States. In Nat Immunol, 2008
Here I highlight recent advances in our understanding of the structural properties and signaling pathways of the inhibitory and activating NK cell receptors, with a particular focus on the ITAM-dependent activating receptors, the NKG2D-DAP10 receptor complexes and the CD244 receptor system.