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Neuroblastoma, suppression of tumorigenicity 1

DAN, PARN, NO-3, poly(A)-specific ribonuclease
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream chromosome 1 open reading frame 151 locus (GeneID 440574) have been observed.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, caspase-3
Papers on DAN
Molecular recognition of mRNA 5' cap by 3' poly(a)-specific ribonuclease (PARN) differs from interactions known for other cap-binding proteins.
Virtanen et al., Warsaw, Poland. In Biochim Biophys Acta, Feb 2016
Poly(A)-specific ribonuclease (PARN) is a dimeric exoribonuclease that efficiently degrades mRNA 3' poly(A) tails while also simultaneously interacting with the mRNA 5' cap.
A Polyadenylation-Dependent 3' End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA.
Bachand et al., Sherbrooke, Canada. In Cell Rep, Jan 2016
Here, we show that hTR is matured via a polyadenylation-dependent pathway that relies on the nuclear poly(A)-binding protein PABPN1 and the poly(A)-specific RNase PARN.
Human Telomerase RNA Processing and Quality Control.
Baumann et al., Kansas City, United States. In Cell Rep, Jan 2016
Whereas longer transcripts are predominantly degraded, shorter precursor RNAs are oligo-adenylated by TRF4-2 and either processed by poly(A)-specific ribonuclease (PARN) or degraded by the exosome.
Desacetyl nimbinene inhibits breast cancer growth and metastasis through reactive oxygen species mediated mechanisms.
Lakshmanaswamy et al., El Paso, United States. In Tumour Biol, Jan 2016
The main objective of this study is to investigate the anticancer effect of desacetyl nimbinene (DAN; an active ingredient of neem) against breast cancer.
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.
Agarwal et al., Boston, United States. In Nat Genet, Dec 2015
Mutations in the PARN gene (encoding poly(A)-specific ribonuclease) cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita, but how PARN deficiency impairs telomere maintenance is unclear.
The Mechanisms of Far Transfer From Cognitive Training: Review and Hypothesis.
Parasuraman et al., In Neuropsychology, Dec 2015
METHOD: We review the relevant strands of evidence on cognitive-training-related changes in (a) cortical mechanisms of distraction suppression, and (b) activation of the dorsal attention network (DAN).
Diabetic Neuropathies
Nevoret et al., Madagascar. In Unknown Journal, Sep 2015
The reported prevalence of diabetic autonomic neuropathy (DAN) varies widely (7.7 to 90%) depending on the cohort studied and the methods used for diagnosis, and can affect any organ system.
Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.
Balatsos et al., Lárisa, Greece. In Mol Cancer, 2014
Quantitative real-time PCR showed that four deadenylases, PARN, CNOT6, CNOT7 and NOC, are differentially expressed in our SCC clinical samples.
Treating Diabetic Neuropathy: Present Strategies and Emerging Solutions.
Malik et al., Manchester, United Kingdom. In Rev Diabet Stud, 2014
Distal symmetrical polyneuropathy (DSPN) with painful diabetic neuropathy, occurring in around 20% of diabetes patients, and diabetic autonomic neuropathy (DAN) are the most common manifestations of DPN.
The DAN family: modulators of TGF-β signaling and beyond.
Thompson et al., Cincinnati, United States. In Protein Sci, 2014
In particular, recent studies have implicated members of the differential screening-selected gene in neuroblastoma (DAN) family in disease such as renal fibrosis, pulmonary arterial hypertension, and reactivation of metastatic cancer stem cells.
The cross-functional role of frontoparietal regions in cognition: internal attention as the overarching mechanism.
Sack et al., Maastricht, Netherlands. In Prog Neurobiol, 2014
The aim of this review is twofold: First, it discusses evidence in support of the concept of internal attention and the so-called dorsal attention network (DAN) as its neural source with respect to three cognitive functions (working memory, episodic retrieval, and mental imagery).
Kiss your tail goodbye: the role of PARN, Nocturnin, and Angel deadenylases in mRNA biology.
Wilusz et al., Fort Collins, United States. In Biochim Biophys Acta, 2013
PARN, Nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells.
Poly(A)-specific ribonuclease (PARN): an allosterically regulated, processive and mRNA cap-interacting deadenylase.
Nissbeck et al., Uppsala, Sweden. In Crit Rev Biochem Mol Biol, 2013
Here, we review poly(A)-specific ribonuclease (PARN), which is one of the biochemically best characterized deadenylases.
Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Richter et al., Worcester, United States. In Mol Cell, 2012
poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
DAN (NBL1) specifically antagonizes BMP2 and BMP4 and modulates the actions of GDF9, BMP2, and BMP4 in the rat ovary.
Luo et al., Taipei, Taiwan. In Biol Reprod, 2012
The findings suggested that the NBL1 gradient in granulosa cells, established by oocyte-derived GDF9, may serve as an antagonist barrier that modulates the actions of theca-derived BMP4 and granulosa/theca-derived BMP2 during folliculogenesis.
Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering.
Virtanen et al., Warsaw, Poland. In Biophys Chem, 2011
The atomic force microscopy images of single PARN molecules reveal compact ellipsoidal dimers (10.9 x 7.6 x 4.6nm).
Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.
Wernert et al., Bonn, Germany. In Int J Mol Med, 2011
CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands
NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma.
Jarzab et al., Katowice, Poland. In Folia Histochem Cytobiol, 2008
This study was to establish if NBL1 was a molecular marker for pancreatic cancer.
Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations.
Sandberg et al., Chicago, United States. In N Engl J Med, 1993
METHODS: We isolated a 0.74-kb BamHI fragment from a complementary DAN (cDNA) clone of the MLL gene.
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells.
Smithies et al., Madison, United States. In Nature, 1988
These are, first, the characterization of mouse embryonic stem (ES) cells that can still enter the germline after genetic manipulation in culture and second, the demonstration that homologous recombination between a native target chromosomal gene and exogenous DAN can be used in culture to modify specifically the target locus.
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