Human Telomerase RNA Processing and Quality Control.
Kansas City, United States. In Cell Rep, Jan 2016
Whereas longer transcripts are predominantly degraded, shorter precursor RNAs are oligo-adenylated by TRF4-2 and either processed by poly(A)-specific ribonuclease (PARN) or degraded by the exosome.
Madagascar. In Unknown Journal, Sep 2015
The reported prevalence of diabetic autonomic neuropathy (DAN) varies widely (7.7 to 90%) depending on the cohort studied and the methods used for diagnosis, and can affect any organ system.
The DAN family: modulators of TGF-β signaling and beyond.
Cincinnati, United States. In Protein Sci, 2014
In particular, recent studies have implicated members of the differential screening-selected gene in neuroblastoma (DAN) family in disease such as renal fibrosis, pulmonary arterial hypertension, and reactivation of metastatic cancer stem cells.
Autonomic neuropathy in experimental models of diabetes mellitus.
Saint Louis, United States. In Handb Clin Neurol, 2013
Nonetheless, animal studies have resulted in a variety of insights into the pathogenesis, neuropathology, and pathophysiology of diabetic autonomic neuropathy (DAN) with significant and, in some cases, remarkable correspondence between rodent models and human disease.
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells.
Madison, United States. In Nature, 1988
These are, first, the characterization of mouse embryonic stem (ES) cells that can still enter the germline after genetic manipulation in culture and second, the demonstration that homologous recombination between a native target chromosomal gene and exogenous DAN can be used in culture to modify specifically the target locus.