Activation of TLR3/interferon signaling pathway by bluetongue virus results in HIV inhibition in macrophages.
Philadelphia, United States. In Faseb J, Dec 2015
These findings demonstrate the potential of BTV-mediated TLR3 activation in macrophage innate immunity against HIV.-Dai, M., Wang, X., Li, J.-L., Zhou, Y., Sang, M., Liu, J.-B., Wu, J.-G., Ho, W.-Z. Activation of TLR3/interferon signaling pathway by bluetongue virus results in HIV inhibition in macrophages.
How do reducing equivalents increase insulin secretion?
In J Clin Invest, Nov 2015
In this issue, Ferdaoussi, Dai, and colleagues reveal that insulin secretion is amplified by cytosolic isocitrate dehydrogenase-dependent transfer of reducing equivalents, which generates NADPH and reduced glutathione, which in turn activates sentrin/SUMO-specific protease-1 (SENP1).
Endothelin-1 and its role in the pathogenesis of infectious diseases.
United States. In Life Sci, 2014
Clinical and experimental data indicate that ET-1 is involved in the pathogenesis of sepsis (Tschaikowsky et al., 2000; Goto et al., 2012), viral and bacterial pneumonia (Schuetz et al., 2008; Samransamruajkit et al., 2002), Rickettsia conorii infections (Davi et al., 1995), Chagas disease (Petkova et al., 2000, 2001), and severe malaria (Dai et al., 2012; Machado et al., 2006; Wenisch et al., 1996a; Dietmann et al., 2008).
Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.
Iowa City, United States. In Clin Exp Immunol, 2010
Thus, endosomal Toll-like receptors (TLR) mediate responses to double-stranded RNA (TLR-3), single-stranded RNA (TLR-7/8) or unmethylated bacterial cytosine (phosphodiester) guanine (CpG)-DNA (TLR-9), while DNA-dependent activator of IRFs/Z-DNA binding protein 1 (DAI/ZBP1), haematopoietic IFN-inducible nuclear protein-200 (p202), absent in melanoma 2 (AIM2), RNA polymerase III, retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) mediate responses to cytosolic dsDNA or dsRNA, respectively.
The innate immune response to DNA.
Calgary, Canada. In Semin Immunol, 2009
Recently, novel cytosolic DNA sensors have been uncovered that include ZBP1 or DNA-dependent activator of interferon-regulatory factors (DAI) and a DNA sensing inflammasome consisting of the HIN200 protein, absent in melanoma 2 (AIM2).
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Japan. In Nature, 2008
Plasmid-DNA-activated, TBK1-dependent signalling and the resultant type-I interferon receptor-mediated signalling was required for induction of antigen-specific B and T cells, which occurred even in the absence of innate immune signalling through a well known CpG DNA sensor-Toll-like receptor 9 (TLR9) or Z-DNA binding protein 1 (ZBP1, also known as DAI, which was recently reported as a potential B-form DNA sensor).
TRPV1 Receptors and Signal Transduction
Boca Raton, United States. In Unknown Journal, 0001
Similar to many other channels, TRPV1 contains multiple phosphorylation sites in its amino acid sequence for protein kinase C (PKC) (Bhave et al., 2003; Dai et al., 2004; Premkumar et al., 2004), protein kinase A (PKA) (Bhave et al., 2002; De Petrocellis et al., 2001; Rathee et al., 2002) and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).