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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ada2b

dAda2b, ADA2b, ADA2s, Ada2beta, hAda2beta, dADA2s
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010] (from NCBI)
Top mentioned proteins: Histone, ADA2, N-acetyl-beta-D-glucosaminidase, ADA3, CAN
Papers on dAda2b
Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5.
New
Tora et al., Bristol, United Kingdom. In J Biol Chem, Dec 2015
The HAT module of ATAC is composed of GCN5, ADA2a, ADA3, and SGF29, whereas in the SAGA HAT module ADA2b is present instead of ADA2a.
Epigenetic control of juvenile-to-adult phase transition by the Arabidopsis SAGA-like complex.
New
Noh et al., Seoul, South Korea. In Plant J, Aug 2015
In this study, we demonstrate that the HAG1/GCN5- and PRZ1/ADA2b-containing SAGA-like histone acetyltransferase (HAT) complex directly controls the transcription of SPLs and determines the time for juvenile-to-adult phase transition.
The Arabidopsis transcription factor bZIP11 activates auxin-mediated transcription by recruiting the histone acetylation machinery.
Dröge-Laser et al., Würzburg, Germany. In Nat Commun, 2013
Here we present a converse mechanism where Arabidopsis bZIP11-related basic leucine zipper (bZIP) transcription factors interact via an amino-terminal activation domain with ADA2b adapter proteins to recruit the histone acetylation machinery to specific auxin-responsive genes.
Involvement of elevated proline accumulation in enhanced osmotic stress tolerance in Arabidopsis conferred by chimeric repressor gene silencing technology.
Tada et al., Hachiōji, Japan. In Plant Signal Behav, 2013
Arabidopsis plants transformed with a chimeric repressor for 6 transcription factors (TFs), including ADA2b, Msantd, DDF1, DREB26, AtGeBP, and ATHB23, that were converted by Chimeric REpressor gene Silencing Technology (CRES-T), show elevated salt and osmotic stress tolerance compared with wild type (WT) plants.
Functional characterization and gene expression profiling of Drosophila melanogaster short dADA2b isoform-containing dSAGA complexes.
Boros et al., Szeged, Hungary. In Bmc Genomics, 2012
ADA2b is present in the SAGA complex, which plays roles in various chromatin-related processes via histone H3 modifications and by other mechanisms.
The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation.
Boros et al., Szeged, Hungary. In Febs Lett, 2012
In metazoa ADA2a is present in the histone H4-specific ATAC, and ADA2b in the histone H3-specific SAGA complex.
The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses.
Review
GeneRIF
Tsementzi et al., Thessaloníki, Greece. In Plant Signal Behav, 2011
ADA2b is required for the expression of genes involved in abiotic stress either by controlling H3 and H4 acetylation.
Arabidopsis thaliana transcriptional co-activators ADA2b and SGF29a are implicated in salt stress responses.
GeneRIF
Vlachonasios et al., Thessaloníki, Greece. In Planta, 2011
The role of SGF29a and ADA2b in salt stress responses, was explored
Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes.
Coupland et al., Köln, Germany. In Proc Natl Acad Sci U S A, 2010
Furthermore, ADA2b, an ESD4 interactor that was SUMOylated in the E. coli system, also was shown to be SUMOylated in Arabidopsis.
Histone dynamics and roles of histone acetyltransferases during cold-induced gene regulation in Arabidopsis.
Triezenberg et al., East Lansing, United States. In Plant Mol Biol, 2010
Plants homozygous for T-DNA disruption alleles of GCN5 (encoding a histone acetyltransferase) or ADA2b (a GCN5-interacting protein) show diminished expression of COR genes during cold acclimation.
Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila.
Boros et al., Szeged, Hungary. In Mol Cell Biol, 2010
Mutants of dAda2b, a subunit of the dSAGA histone acetyltransferase complex, do not share phenotype characteristics and RNA profile alterations with dAda2a mutants, indicating that the ecdysone biosynthesis genes are regulated by dATAC, but not by dSAGA.
Putative Arabidopsis transcriptional adaptor protein (PROPORZ1) is required to modulate histone acetylation in response to auxin.
GeneRIF
Luschnig et al., Vienna, Austria. In Proc Natl Acad Sci U S A, 2010
PRZ1 is involved in the modulation of histone modifications and corresponding adjustments in gene expression of KIP RELATED PROTEIN (KRP) CDK inhibitor genes in response to auxin.
The loss of histone H3 lysine 9 acetylation due to dSAGA-specific dAda2b mutation influences the expression of only a small subset of genes.
Boros et al., Szeged, Hungary. In Nucleic Acids Res, 2009
In Drosophila, the dADA2b-containing dSAGA complex is involved in histone H3 lysine 9 and 14 acetylation.
GAL4 induces transcriptionally active puff in the absence of dSAGA- and ATAC-specific chromatin acetylation in the Drosophila melanogaster polytene chromosome.
Boros et al., Szeged, Hungary. In Chromosoma, 2009
In accordance with the above, puff formation as well as localization of Pol II and GAL4 was detectable at the 61C region in dAda2b and dAda2a null homozygotes, which are dSAGA- and ATAC-specific mutants, respectively.
Members of the GCN5 histone acetyltransferase complex regulate PLETHORA-mediated root stem cell niche maintenance and transit amplifying cell proliferation in Arabidopsis.
Scheres et al., Utrecht, Netherlands. In Plant Cell, 2009
The GCN5-associated factor ADA2b (for alteration/deficiency in activation 2b) is also positioned in the PLT pathway and regulates PLT expression, similar to GCN5.
Two Arabidopsis orthologs of the transcriptional coactivator ADA2 have distinct biological functions.
GeneRIF
Triezenberg et al., Allentown, United States. In Biochim Biophys Acta, 2009
Data suggest that ADA2a and ADA2b each work independently with GCN5 to affect genome function in Arabidopsis.
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis.
GeneRIF
Roeder et al., New York City, United States. In Mol Cell Biol, 2009
ADA2a and ADA2b, two human homologues of yeast Ada2, each have the ability to form a heterotrimer with ADA3 and GCN5L but that only the ADA2b homologue is found in STAGA.
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