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Defender against cell death 1

DAD1
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, PrP, bcl-2, HAD
Papers on DAD1
A comparison of presynaptic and postsynaptic dopaminergic agonists on inhibitory control performance in rats perinatally exposed to PCBs.
New
Sable et al., Memphis, United States. In Neurotoxicol Teratol, Jul 2015
The current study served to determine if microinjections of different DA agonists (the presynaptic DA transporter inhibitor and vesicular monoamine transporter agonist bupropion, the postsynaptic DA receptor 2 (DAD2) agonist quinpirole, and the postsynaptic DA receptor 1 (DAD1) agonist SKF81297) directly into the mPFC would differentially improve performance on an inhibitory control task in rats perinatally exposed to an environmentally relevant PCB mixture.
Asymmetric localizations of the ABC transporter PaPDR1 trace paths of directional strigolactone transport.
New
Borghi et al., Zürich, Switzerland. In Curr Biol, Apr 2015
In root tips, PaPDR1 is co-expressed with the strigolactone biosynthetic gene DAD1 (CCD8), and it is localized at the apical membrane of root hypodermal cells, presumably mediating the shootward transport of strigolactone.
The direct assignment option as a modular design component: an example for the setting of two predefined subgroups.
Mandrekar et al., Poughkeepsie, United States. In Comput Math Methods Med, 2014
METHODS: We power the 2-subgroup direct assignment option design with 1 IA (DAD-1) to test for separate subgroup main effects, with assessment of power to detect an interaction in a post-hoc test.
A genome-wide association study of asthma symptoms in Latin American children.
Barreto et al., Salvador, Brazil. In Bmc Genet, 2014
RESULTS: Two chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the 14q11 region flanking the DAD1 and OXA1L genes (rs1999071, MAF 0.32, OR 1.78, 95% CI 1.45-2.18,
Feeding on resistant rice leads to enhanced expression of defender against apoptotic cell death (OoDAD1) in the Asian rice gall midge.
Nair et al., New Delhi, India. In Bmc Plant Biol, 2014
The present study points towards the likely involvement of a defender against apoptotic cell death gene (DAD1) in the insect in response to the host defense.
The incentive amplifying effects of nicotine are reduced by selective and non-selective dopamine antagonists in rats.
Robinson et al., Johnson City, United States. In Pharmacol Biochem Behav, 2014
The DAD1 antagonist SCH-23390 and the DAD2/3 antagonist eticlopride reduced conditioned approach in all rats, but specifically reduced goal tracking in the saline pretreated rats and sign tracking in the nicotine pretreated rats.
Cryotolerance and global gene-expression patterns of Bos taurus indicus and Bos taurus taurus in vitro- and in vivo-produced blastocysts.
Landim-Alvarenga et al., Botucatu, Brazil. In Reprod Fertil Dev, 2014
The expression profiles of genes related to mitochondrial metabolism (ATP5B), oxidative stress (GPX4), apoptosis (DAD1, DAP, PRDX2), heat shock (HSPA5), pregnancy (IFNT2, PAG2) and cell differentiation (KRT18) varied between experimental groups.
Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway.
Peng et al., Shanghai, China. In Mol Cell Proteomics, 2014
Mass spectrometry results were then further confirmed by assessing six representative proteins (ACADL, EPHX2, MSI2, DKK4, JUP, and DAD1) in individual specimens with immunohistochemistry. Upon mapping of the differentially expressed proteins to the Kyoto Encyclopedia of Genes and Genomes pathways database, we found several new cell-adhesion molecules that could be used as pathologic biomarkers.
Exploring the statistical and clinical impact of two interim analyses on the Phase II design with option for direct assignment.
Sargent et al., Poughkeepsie, United States. In Contemp Clin Trials, 2014
METHODS: We compared the statistical properties and clinical relevance of the direct assignment design with two IA (DAD-2) versus a balanced randomized design with two IA (BRD-2) and a direct assignment design with one IA (DAD-1), over a range of response rate ratios (2.0-3.0).
Wound-induced expression of DEFECTIVE IN ANTHER DEHISCENCE1 and DAD1-like lipase genes is mediated by both CORONATINE INSENSITIVE1-dependent and independent pathways in Arabidopsis thaliana.
Ishiguro et al., Nagoya, Japan. In Plant Cell Rep, 2014
Endogenous JA production is not necessary for wound-induced expression of JA-biosynthetic lipase genes such as DAD1 in Arabidopsis.
The NAC-like gene ANTHER INDEHISCENCE FACTOR acts as a repressor that controls anther dehiscence by regulating genes in the jasmonate biosynthesis pathway in Arabidopsis.
Yang et al., T'ai-chung-shih, Taiwan. In J Exp Bot, 2014
The defect in anther dehiscence was due to the down-regulation of genes that participate in jasmonic acid (JA) biosynthesis, such as DAD1/AOS/AOC3/OPR3/OPCL1.
A gain-of-function mutation in IAA8 alters Arabidopsis floral organ development by change of jasmonic acid level.
Lu et al., Wuhan, China. In Plant Mol Biol, 2013
These results indicated that in IAA8::GFP-mIAA8 plants, JA biosynthetic genes including DAD1 (AT2G44810), AOS (AT5G42650) and ORP3 (AT2G06050) were dramatically down-regulated and JA level in the flowers was reduced to 70 % of that in wild-type.
Profiling of ileal carcinoids.
Review
Nilsson, Göteborg, Sweden. In Neuroendocrinology, 2012
RESULTS: Genome-wide association studies have shown that single nucleotide polymorphisms (SNPs) at IL12A and DAD1 are associated with an increased risk of ileal carcinoids.
Genetic associations with sporadic neuroendocrine tumor risk.
GeneRIF
Kulke et al., Boston, United States. In Carcinogenesis, 2011
single-nucleotide polymorphisms in DAD1 gene is associated with neuroendocrine tumor.
Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
GeneRIF
Demiryurek et al., Gaziantep, Turkey. In Endocr Pathol, 2011
DAD1 gene expression is decreased in follicular variant of papillary thyroid carcinoma.
The Dad1 subunit of the yeast kinetochore Dam1 complex is an intrinsically disordered protein.
GeneRIF
Grant et al., New York City, United States. In Biochem Biophys Res Commun, 2010
the work presented here shows that are differences between Dad1 from C. albicans and S. cerevisiae.
High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss.
GeneRIF
Shivdasani et al., Boston, United States. In Genes Chromosomes Cancer, 2008
DAD1 protein overexpression is associated with small bowel carcinoid tumors
Production and initial characterization of Dad1p, a component of the Dam1-DASH kinetochore complex.
GeneRIF
Scherrer et al., New York City, United States. In Plos One, 2007
The expression, solubilization, purification and refolding of Dad1p, one of the Dam1-DASH complex subunits, is reported.
An evolving view of the eukaryotic oligosaccharyltransferase.
Review
Gilmore et al., Worcester, United States. In Glycobiology, 2006
The yeast and vertebrate OST are surprisingly complex hetero-oligomeric proteins consisting of seven or eight subunits (Ost1p, Ost2p, Ost3p/Ost6p, Ost4p, Ost5p, Stt3p, Wbp1p, and Swp1p in yeast; ribophorin I, DAD1, N33/IAP, OST4, STT3A/STT3B, Ost48, and ribophorin II in mammals).
Gene expression profiling in anaplastic large cell lymphoma and Hodgkin's disease.
Review
Brousset et al., Toulouse, France. In Leuk Lymphoma, 2004
In addition to the defender against death cell 1 (DAD1) gene, overexpressed clones corresponded mostly to expressed sequence tags (ESTs).
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