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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Disabled homolog 2, mitogen-responsive phosphoprotein

Dab2, Doc2, p96, Doc2alpha
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, Akt, Munc13
Papers on Dab2
Discovery of signature genes in gastric cancer associated with prognosis.
New
Ma et al., In Neoplasma, Feb 2016
A total of 17 genes were identified as signature genes, such as DAB2, ALDH2, CD58, CITED2, BNIP3L, SLC43A2, FAU and COL5A1.Many signature genes associated with prognosis of GC were identified in present study, some of which have been implicated in the pathogenesis of GC.
Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling.
New
Murry et al., Seattle, United States. In Proc Natl Acad Sci U S A, Feb 2016
We identified Disabled 2 (DAB2) as one of the most dynamically expressed proteins in hESCs, CPCs, and cardiomyocytes.
DAB2IP in cancer.
Review
New
Xie et al., Wuhan, China. In Oncotarget, Jan 2016
UNASSIGNED: DOC-2/DAB2 is a member of the disable gene family that features tumor-inhibiting activity.
Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics.
New
Stevens et al., Tampa, United States. In Mol Cell Proteomics, Dec 2015
In addition, the proteomic data identified a novel activation marker, DAB2, which is involved in clathrin-mediated endocytosis and is significantly different between M2a and either M1 or M2b states.
MicroRNA-106b is involved in transforming growth factor β1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma.
New
Geng et al., Beijing, China. In J Exp Clin Cancer Res, Dec 2015
The expression of the miR-106b target gene DAB2 in human cervical tissues and cell lines were measured by qRT-PCR, western blot and immunohistochemistry. Dual-luciferase reporter assay was used to identify DAB2 as a miR-106b-directed target gene.
microRNA-32 induces radioresistance by targeting DAB2IP and regulating autophagy in prostate cancer cells.
New
Liu et al., Loudi, China. In Oncol Lett, Oct 2015
In the present study, it was found that DAB2 interacting protein (DAB2IP), the miR-32-dependent tumor-suppressor gene, was downregulated and induced autophagy and inhibited radiotherapy-induced apoptosis in PCa cells.
A Versatile Monoclonal Antibody Specific Against Human DAB2IP.
New
Wu et al., Fuzhou, China. In Monoclon Antib Immunodiagn Immunother, Aug 2015
Human DAB2 interaction protein (DAB2IP) is a member of Ras-GTPase activating protein family and functions as a tumor suppressor, implying it could serve as a prognostic biomarker in cancers.
A Novel Monoclonal Antibody Against Human DAB2IP.
New
Hu et al., Chengdu, China. In Monoclon Antib Immunodiagn Immunother, Aug 2015
DAB2 interactive protein (DAB2IP), also known as ASK1-interacting protein-1 (AIP1), a novel member of the RasGTPase-activating protein family, plays a key role in tumor suppression during cancer progression and is highly expressed in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs).
Micro ribonucleic acid-93 promotes proliferation and migration of esophageal squamous cell carcinoma by targeting disabled 2.
New
Zhao et al., Suzhou, China. In Thorac Cancer, Jul 2015
RESULTS: A significant upregulation of miR-93 expression in ESCC tissues was determined, combined with a downregulation of the predicted target gene, disabled 2 (DAB2).
The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp.
Review
New
Moreno et al., Cambridge, United States. In Cell Calcium, Mar 2015
Microneme secretion has also been shown to depend on the C2 domain containing protein DOC2 in both Plasmodium spp.
Frequent loss expression of dab2 and promotor hypermethylation in human cancers: a meta-analysis and systematic review.
Review
Xie et al., China. In Pak J Med Sci, 2014
Objective : Disabled-2 (Dab2) is an important endocytic adaptor which plays an inhibition role in cancer cell growth.
Gastric cancer: epidemiologic aspects.
Review
Rokkas et al., Barcelona, Spain. In Helicobacter, 2013
Large meta-analyses confirmed the association between IL8, IL10, TNF-b, TP53 and PSCA, while genetic variation at different genes such as XPG, PLCE1, HFE, ERCC5, EZH2, DOC2, CYP19A1, ALDH2, and CDH1 have been reported to be associated with GC risk.
Genomic and molecular aberrations in malignant peripheral nerve sheath tumor and their roles in personalized target therapy.
Review
Du et al., Tianjin, China. In Surg Oncol, 2013
The involved genes in the significant gains aberrations include BIRC5, CCNE2, DAB2, DDX15, EGFR, DAB2, MSH2, CDK6, HGF, ITGB4, KCNK12, LAMA3, LOXL2, MET, and PDGFRA.
The endocytic adaptor protein Disabled-2 is required for cellular uptake of fibrinogen.
GeneRIF
Tseng et al., Taiwan. In Biochim Biophys Acta, 2012
These findings thereby define an adaptor-specific mechanism in the control of fibrinogen uptake and implicate that DAB2 is the key adaptor in the clathrin-associated endocytic complexes to mediate fibrinogen internalization.
Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.
GeneRIF
Jin et al., New Haven, United States. In Dev Cell, 2012
inhibition of Dab2 decreases phosphorylation of SMAD-1, 5, and 8
Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin.
GeneRIF
Howe et al., Charleston, United States. In Embo J, 2012
The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.
Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA-4 during differentiation of F9 cells.
GeneRIF
Park et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these results indicate that p96 Dab2 plays a key role in the extra-embryonic endodermal differentiation process.
Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells.
GeneRIF
Swiatecka-Urban et al., Pittsburgh, United States. In J Biol Chem, 2012
Dab2 mediates AP-2 independent recruitment of CFTR to CCVs in polarized human airway epithelial cells.
A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.
Impact
Gubbels et al., Boston, United States. In Science, 2012
DOC2 proteins recruit the membrane fusion machinery required for exocytosis in a Ca(2+)-dependent fashion.
New loci associated with kidney function and chronic kidney disease.
Impact
Fox et al., Baltimore, United States. In Nat Genet, 2010
Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
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